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ESPREsperion Therapeutics, Inc.
$3.15$655M
Overview & Verdict
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ESPR logoEsperion Therapeutics, Inc.(ESPR)Earnings, Financials & Key Ratios

ESPR•NASDAQ
$3.15
Price updated Jul 6, 2026
SectorHealthcareIndustrySpecialty & Generic PharmaSub-IndustryTherapy-focused branded biopharma
AboutEsperion Therapeutics, Inc., a pharmaceutical company, develops and commercializes medicines for the treatment of patients with elevated low density lipoprotein cholesterol. Its lead product candidates are NEXLETOL (bempedoic acid) and NEXLIZET (bempedoic acid and ezetimibe) tablets for the treatment of patients with atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia. The company has a license and collaboration agreement with Daiichi Sankyo Europe GmbH; and Serometrix to in-license its oral, small molecule PCSK9 inhibitor program. Esperion Therapeutics, Inc. was incorporated in 2008 and is headquartered in Ann Arbor, Michigan.Show more
  • Revenue$403M+21.3%
  • EBITDA$60M+10.9%
  • Net Income-$23M+56.2%
  • EPS (Diluted)-0.11+60.7%
  • Gross Margin67.95%-14.4%
  • EBITDA Margin14.98%-8.6%
  • Operating Margin14.95%-8.7%
  • Net Margin-5.63%+63.9%

ESPR Price & Volume

Esperion Therapeutics, Inc. (ESPR) stock price & volume — 10-year historical chart

Loading chart...

Volatile Milestone Revenue Masks Structural Profitability Challenges

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Strained
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Commercial ramp-up execution risk

Key Thesis Takeaways

  • Esperion Therapeutics faces a precarious financial outlook characterized by erratic revenue growth, which swung from a 52.8% contraction in 2025Q1 to a 143.7% expansion in 2025Q4, largely driven by lumpy milestone recognition rather than consistent commercial demand.
  • The company's reliance on external financing is underscored by a persistent negative equity position of -$307.9M as of 2026Q1, raising significant concerns regarding long-term capital sustainability.
  • Investors should monitor the firm's inability to achieve consistent operating leverage, as evidenced by the swing from an $85.2M operating profit in 2025Q4 to a $6.6M loss in 2026Q1.

Verdict Logic

the company's inability to maintain positive equity, which stood at -$307.9M in 2026Q1, combined with extreme quarterly cash flow volatility, suggests significant execution risk for long-term investors.

ESPR Growth Metrics

Esperion Therapeutics, Inc. (ESPR) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years12.12%
3 Years74.8%
TTM61.13%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM95.16%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM91.97%

Return on Capital

10 Years-55.74%
5 Years-37.82%
3 Years-10.6%
Last Year45.89%

ESPR Recent Earnings

Esperion Therapeutics, Inc. (ESPR) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 7/12 qtrs (58%)
Q2 2026Latest
May 8, 2026
Metric
Actual
Est
EPS
$0.10-150.0%
$0.04
Rev
$80M-5.2%
$85M
Q2 2026
May 7, 2026
Metric
Actual
Est
EPS
$0.01+75.0%
$0.04
Rev
$84M-1.1%
$85M
Q2 2026
Mar 10, 2026
Metric
Actual
Est
EPS
$0.22-4.3%
$0.23
Rev
$168M+1.2%
$166M
Q4 2025
Nov 6, 2025
Metric
Actual
Est
EPS
$0.16-77.8%
$0.09
Rev
$87M-47.1%
$165M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 8, 2026
$0.10vs $0.04-150.0%
$80Mvs $85M-5.2%
Q2 2026May 7, 2026
$0.01vs $0.04+75.0%
$84Mvs $85M-1.1%
Q2 2026Mar 10, 2026
$0.22vs $0.23-4.3%
$168Mvs $166M+1.2%
Q4 2025Nov 6, 2025
$0.16vs $0.09-77.8%
$87Mvs $165M-47.1%
Based on last 12 quarters of dataView full earnings history →

Peers Comparison

Key metrics vs top competitors for Esperion Therapeutics, Inc. (ESPR)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ESPR logoESPREsperion Therapeutics, Inc.Current
$3.15$654.91M-28.6421.31%-5.63%——
MDGL logoMDGLMadrigal Pharmaceuticals, Inc.
$529.48$12.21B-41.20432.05%-27.32%-50.15%—
EWTX logoEWTXEdgewise Therapeutics, Inc.
$40.10$4.31B-24.60——-32.55%—
PRTA logoPRTAProthena Corporation plc
$9.50$497.36M-2.10-92.84%-260.92%-49.88%—
RARE logoRAREUltragenyx Pharmaceutical Inc.
$33.70$3.31B-5.7820.13%-91.03%——
ACAD logoACADACADIA Pharmaceuticals Inc.
$25.77$4.41B11.2511.87%34.3%35.65%—

Compare ESPR vs Peers

Esperion Therapeutics, Inc. (ESPR) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs MDGL

Most directly comparable listed peer for ESPR.

Scale Benchmark

vs LLY

Larger-name benchmark to compare ESPR against a more recognizable public peer.

Peer Set

Compare Top 5

vs MDGL, EWTX, PRTA, RARE

ESPR SEC Filings & Documents

Esperion Therapeutics, Inc. (ESPR) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 1, 2026·SEC

Material company update

Apr 2, 2026·SEC

Material company update

Mar 10, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 10, 2026·SEC

FY 2025

Mar 7, 2025·SEC

FY 2024

Feb 27, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 8, 2026·SEC

FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 13, 2025·SEC

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ESPR Frequently Asked Questions

Esperion Therapeutics, Inc. (ESPR) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Esperion Therapeutics, Inc.'s revenue?

Esperion Therapeutics, Inc. (ESPR) reported $418.2M in revenue for fiscal year 2025.

How fast is Esperion Therapeutics, Inc. growing?

Esperion Therapeutics, Inc. (ESPR) grew revenue by 21.3% over the past year. This is strong growth.

Is ESPR profitable?

Esperion Therapeutics, Inc. (ESPR) reported a net loss of $7.4M for fiscal year 2025.

Dividend & Returns
What is Esperion Therapeutics, Inc.'s free cash flow?

Esperion Therapeutics, Inc. (ESPR) had negative free cash flow of $18.2M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ESPR back in 1999?

Total return calculator · dividends reinvested · 27+ years of data

See returns →