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RAREUltragenyx Pharmaceutical Inc.
$35.87$3.5B
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RARE logoUltragenyx Pharmaceutical Inc.(RARE)Earnings, Financials & Key Ratios

RARE•NASDAQ
$35.87
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Rare Disease Biopharma
AboutUltragenyx Pharmaceutical Inc., a biopharmaceutical company, focuses on the identification, acquisition, development, and commercialization of novel products for the treatment of rare and ultra-rare genetic diseases in North America, Europe, and internationally. Its biologic products include Crysvita (burosumab), an antibody targeting fibroblast growth factor 23 for the treatment of X-linked hypophosphatemia, as well as tumor-induced osteomalacia; Mepsevii, an enzyme replacement therapy for the treatment of children and adults with Mucopolysaccharidosis VII; Dojolvi for treating long-chain fatty acid oxidation disorders; and Evkeeza (evinacumab) for the treatment of homozygous familial hypercholesterolemia. The company's products candidatures include DTX401, an adeno-associated virus 8 (AAV8) gene therapy clinical candidate for the treatment of patients with glycogen storage disease type Ia; DTX301, an AAV8 gene therapy for the treatment of patients with ornithine transcarbamylase; UX143, a human monoclonal antibody for the treatment of osteogenesis imperfecta; GTX-102, an antisense oligonucleotide for the treatment of Angelman syndrome; UX701, for the treatment of Wilson disease; and UX053 for the treatment of glycogen storage disease type III. Ultragenyx Pharmaceutical Inc. has collaboration and license agreement with Kyowa Kirin Co., Ltd.; Saint Louis University; Baylor Research Institute; REGENXBIO Inc.; Bayer Healthcare LLC; GeneTx; Mereo; University of Pennsylvania; Arcturus Therapeutics Holdings Inc., Solid Biosciences Inc.; and Daiichi Sankyo Co., Ltd. Ultragenyx Pharmaceutical Inc. was incorporated in 2010 and is headquartered in Novato, California.Show more
  • Revenue$673M+20.1%
  • EBITDA-$500M
  • Net Income-$575M-1.0%
  • EPS (Diluted)-5.83+7.3%
  • Gross Margin83.8%-2.9%
  • EBITDA Margin-74.29%+16.8%
  • Operating Margin-79.49%+16.9%
  • Net Margin-85.44%+15.9%
  • ROE-607.51%-187.0%

RARE Price & Volume

Ultragenyx Pharmaceutical Inc. (RARE) stock price & volume — 10-year historical chart

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Persistent R&D Intensity Strains Equity Capital Base

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Sustained High Cash Burn

Key Thesis Takeaways

  • Ultragenyx maintains a high-margin rare disease portfolio, yet its reliance on milestone-driven revenue creates significant quarterly volatility, as evidenced by the 2.4% year-over-year revenue decline in 2026Q1.
  • The company's aggressive R&D investment strategy, which peaked at $216.2M in 2025Q3, continues to outpace gross profit generation and necessitates a precarious reliance on external capital.
  • Investors should monitor the sustainability of the firm's $1.3B debt load and the rapid depletion of cash reserves, which fell to $175.0M in 2026Q1, as these factors pose substantial risks to long-term shareholder value.

Verdict Logic

the company's inability to achieve operating leverage, combined with a negative equity position of $236.0M and a shrinking cash balance, suggests significant ongoing dilution and liquidity risks for investors.

RARE Growth Metrics

Ultragenyx Pharmaceutical Inc. (RARE) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years19.95%
3 Years22.81%
TTM13.33%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-10.88%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-3.91%

Return on Capital

10 Years-48.07%
5 Years-42.58%
3 Years-45.75%
Last Year-46.37%

RARE Recent Earnings

Ultragenyx Pharmaceutical Inc. (RARE) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 4/12 qtrs (33%)●Beat Revenue 6/12 qtrs (50%)
Q2 2026Latest
May 5, 2026
Metric
Actual
Est
EPS
$1.84-23.7%
$1.49
Rev
$136M-14.0%
$158M
Q1 2026
Feb 12, 2026
Metric
Actual
Est
EPS
$1.29-7.5%
$1.20
Rev
$207M+4.2%
$199M
Q4 2025
Nov 4, 2025
Metric
Actual
Est
EPS
$1.81-47.2%
$1.23
Rev
$160M-19.9%
$200M
Q3 2025
Aug 5, 2025
Metric
Actual
Est
EPS
$1.17+7.9%
$1.27
Rev
$166M+0.3%
$166M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 5, 2026
$1.84vs $1.49-23.7%
$136Mvs $158M-14.0%
Q1 2026Feb 12, 2026
$1.29vs $1.20-7.5%
$207Mvs $199M+4.2%
Q4 2025Nov 4, 2025
$1.81vs $1.23-47.2%
$160Mvs $200M-19.9%
Q3 2025Aug 5, 2025
$1.17vs $1.27+7.9%
$166Mvs $166M+0.3%
Based on last 12 quarters of dataView full earnings history →

Latest RARE News

Recent stock market news and headlines for Ultragenyx Pharmaceutical Inc. (RARE)

Zacks Investment Research·Jun 29, 2026
Ultragenyx (RARE) Soars 5.2%: Is Further Upside Left in the Stock?

Ultragenyx (RARE) saw its shares surge in the last session with trading volume being higher than average. The latest trend in earnings estimate revisions may not translate into further price increase in the near term.

Seeking Alpha·Jun 21, 2026
Ultragenyx: The Setrusumab Reset Creates A Cleaner Rare Disease Opportunity

Ultragenyx (RARE) is transitioning from a broad pipeline to a focused rare disease platform, entering a high-catalyst period with four approved products and multiple late-stage assets. Despite a recent Phase 3 failure and Q1 2026 net loss, RARE reaffirmed 2026 revenue guidance of $730–$760 million, supported by a scalable commercial base and cost controls. Key near-term catalysts include FDA reviews for DTX401 and UX111 (PDUFA dates in H2 2026) and pivotal Phase 3 Aspire results for GTX-102 in Angelman syndrome.

GlobeNewsWire·Jun 19, 2026
Ultragenyx Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

NOVATO, Calif., June 19, 2026 (GLOBE NEWSWIRE) -- Ultragenyx Pharmaceutical Inc. (NASDAQ: RARE), a biopharmaceutical company focused on the development and commercialization of novel therapies for rare and ultra-rare diseases, today reported the grant of 44,409 restricted stock units of the company's common stock to 15 newly hired non-executive officers of the company. The awards were approved by the compensation committee of the company's board of directors and granted under the Ultragenyx Employment Inducement Plan, with a grant date of June 16, 2026, as an inducement material to the new employees entering into employment with Ultragenyx in accordance with Nasdaq Listing Rule 5635(c)(4).

Globe News Wire·Jun 19, 2026
Ultragenyx Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

NOVATO, Calif. , June 19, 2026 (GLOBE NEWSWIRE) -- Ultragenyx Pharmaceutical Inc. (NASDAQ: RARE), a biopharmaceutical company focused on the development and commercialization of novel therapies for rare and ultra-rare diseases, today reported the grant of 44,409 restricted stock units of the company's common stock to 15 newly hired non-executive officers of the company.

Peers Comparison

Key metrics vs top competitors for Ultragenyx Pharmaceutical Inc. (RARE)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
RARE logoRAREUltragenyx Pharmaceutical Inc.Current
$35.87$3.53B-6.1520.13%-85.44%-607.51%—
BMRN logoBMRNBioMarin Pharmaceutical Inc.
$60.35$11.61B33.5312.87%8.29%4.41%—
SRPT logoSRPTSarepta Therapeutics, Inc.
$19.79$2.09B-2.7815.58%2.98%4.89%—
IONS logoIONSIonis Pharmaceuticals, Inc.
$86.33$14.27B-36.2733.87%-30.87%-58.57%—
ACAD logoACADACADIA Pharmaceuticals Inc.
$26.20$4.49B11.4411.87%34.3%35.65%—
FOLD logoFOLDAmicus Therapeutics, Inc.
$14.49$4.55B-164.8520.05%-4.27%-12.02%—

Compare RARE vs Peers

Ultragenyx Pharmaceutical Inc. (RARE) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs BMRN

Most directly comparable listed peer for RARE.

Scale Benchmark

vs MEDP

Larger-name benchmark to compare RARE against a more recognizable public peer.

Peer Set

Compare Top 5

vs BMRN, SRPT, IONS, ACAD

RARE SEC Filings & Documents

Ultragenyx Pharmaceutical Inc. (RARE) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 5, 2026·SEC

Material company update

Apr 2, 2026·SEC

Material company update

Mar 30, 2026·SEC

10-K Annual Reports

2
FY 2026

Feb 18, 2026·SEC

FY 2025

Feb 19, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

May 6, 2026·SEC

FY 2025

Nov 5, 2025·SEC

FY 2025

Aug 6, 2025·SEC

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RARE Frequently Asked Questions

Ultragenyx Pharmaceutical Inc. (RARE) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Ultragenyx Pharmaceutical Inc.'s revenue?

Ultragenyx Pharmaceutical Inc. (RARE) reported $669.4M in revenue for fiscal year 2025.

How fast is Ultragenyx Pharmaceutical Inc. growing?

Ultragenyx Pharmaceutical Inc. (RARE) grew revenue by 20.1% over the past year. This is strong growth.

Is RARE profitable?

Ultragenyx Pharmaceutical Inc. (RARE) reported a net loss of $609.4M for fiscal year 2025.

Dividend & Returns
What is RARE's return on equity?

Ultragenyx Pharmaceutical Inc. (RARE) has a return on equity (ROE) of -607.5%. Negative ROE indicates the company is unprofitable.

What is Ultragenyx Pharmaceutical Inc.'s free cash flow?

Ultragenyx Pharmaceutical Inc. (RARE) had negative free cash flow of $487.2M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in RARE back in 2011?

Total return calculator · dividends reinvested · 15+ years of data

See returns →