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ANVSAnnovis Bio, Inc.
$1.92$38M
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ANVS logoAnnovis Bio, Inc.(ANVS)Earnings, Financials & Key Ratios

ANVS•NYSE
$1.92
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutAnnovis Bio, Inc., a clinical stage drug platform company, develops drugs to treat neurodegeneration. The company's lead compound is Buntanetap, an orally administered drug, which has completed Phase 2a clinical trials for the treatment of Alzheimer's disease (AD) and Parkinson's disease, as well as is in clinical trials for Alzheimer's disease in Down Syndrome and other chronic neurodegenerative disorders. It is also developing ANVS405 for protecting the traumatic brain injury and stroke; and ANVS301, which is in Phase I clinical trials to increase cognitive capability in later stages of AD and dementia. The company was incorporated in 2008 and is based in Berwyn, Pennsylvania.Show more
  • Revenue$0
  • EBITDA-$30M-11.2%
  • Net Income-$29M-17.3%
  • EPS (Diluted)-1.40+99.9%
  • ROE-220.61%+93.0%

ANVS Price & Volume

Annovis Bio, Inc. (ANVS) stock price & volume — 10-year historical chart

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Clinical Development Costs Threaten Annovis Bio Liquidity

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Binary clinical trial failure

Key Thesis Takeaways

  • Annovis Bio remains a high-risk, pre-revenue biotechnology firm entirely dependent on external financing to advance its Buntanetap program.
  • The company faces a critical liquidity inflection point as R&D expenditures surged to $16.7 billion in 2026Q1, significantly outpacing historical averages.
  • Investors should monitor the firm's ability to secure non-dilutive capital or strategic partnerships, as the current cash balance of $19.5 million is insufficient to sustain the accelerating burn rate observed in recent quarters.

Verdict Logic

the company's reliance on external capital is unsustainable given the rapid depletion of assets to $16.2 million and the lack of commercial revenue to offset $18.0 million in quarterly operating losses.

ANVS Growth Metrics

Annovis Bio, Inc. (ANVS) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-40.82%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM26.5%

Return on Capital

10 Years-189.83%
5 Years-187.83%
3 Years-271.08%
Last Year-216.04%

ANVS Recent Earnings

Annovis Bio, Inc. (ANVS) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 6/12 qtrs (50%)
Q2 2026Latest
May 15, 2026
Metric
Actual
Est
EPS
$0.63-59.5%
$0.40
Rev
—
—
Q2 2026
Mar 16, 2026
Metric
Actual
Est
EPS
$0.39-26.5%
$0.31
Rev
—
—
Q4 2025
Nov 12, 2025
Metric
Actual
Est
EPS
$0.37-2.8%
$0.36
Rev
—
—
Q3 2025
Aug 12, 2025
Metric
Actual
Est
EPS
$0.32+11.1%
$0.36
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 15, 2026
$0.63vs $0.40-59.5%
—
Q2 2026Mar 16, 2026
$0.39vs $0.31-26.5%
—
Q4 2025Nov 12, 2025
$0.37vs $0.36-2.8%
—
Q3 2025Aug 12, 2025
$0.32vs $0.36+11.1%
—
Based on last 12 quarters of dataView full earnings history →

Latest ANVS News

Recent stock market news and headlines for Annovis Bio, Inc. (ANVS)

GlobeNewsWire·Jul 1, 2026
Annovis Appoints Cheng Fang, Ph.D., as Chief Scientific Officer

MALVERN, Pa., July 01, 2026 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a Phase 3 clinical-stage biotechnology company developing the investigational oral therapy, buntanetap, for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), today announced the promotion of Cheng Fang, Ph.D., to Chief Scientific Officer.

Peers Comparison

Key metrics vs top competitors for Annovis Bio, Inc. (ANVS)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ANVS logoANVSAnnovis Bio, Inc.Current
$1.92$37.77M-1.37——-220.61%—
SAVA logoSAVACassava Sciences, Inc.
$1.32$63.77M-2.54——-95.77%—
PRTA logoPRTAProthena Corporation plc
$9.68$506.78M-2.14-92.84%-260.92%-49.88%—
ACAD logoACADACADIA Pharmaceuticals Inc.
$26.20$4.49B11.4411.87%34.3%35.65%—
AVXL logoAVXLAnavex Life Sciences Corp.
$2.71$251.14M-5.02——-38.76%—
ATHA logoATHAAthira Pharma, Inc.
$4.34$17.12M-0.17——-381.01%—

Compare ANVS vs Peers

Annovis Bio, Inc. (ANVS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs SAVA

Most directly comparable listed peer for ANVS.

Scale Benchmark

vs LLY

Larger-name benchmark to compare ANVS against a more recognizable public peer.

Peer Set

Compare Top 5

vs SAVA, PRTA, ACAD, AVXL

ANVS SEC Filings & Documents

Annovis Bio, Inc. (ANVS) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 20, 2026·SEC

Material company update

May 15, 2026·SEC

Material company update

Apr 10, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 13, 2026·SEC

FY 2025

Mar 21, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

May 15, 2026·SEC

FY 2025

Nov 12, 2025·SEC

FY 2025

Aug 12, 2025·SEC

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ANVS Frequently Asked Questions

Annovis Bio, Inc. (ANVS) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
Is ANVS profitable?

Annovis Bio, Inc. (ANVS) reported a net loss of $40.9M for fiscal year 2025.

Dividend & Returns
What is ANVS's return on equity?

Annovis Bio, Inc. (ANVS) has a return on equity (ROE) of -220.6%. Negative ROE indicates the company is unprofitable.

What is Annovis Bio, Inc.'s free cash flow?

Annovis Bio, Inc. (ANVS) had negative free cash flow of $9.03B in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ANVS back in 2017?

Total return calculator · dividends reinvested · 9+ years of data

See returns →