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ACIUAC Immune S.A.
$2.54$259M
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ACIU logoAC Immune S.A.(ACIU)Earnings, Financials & Key Ratios

ACIU•NASDAQ
$2.54
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutAC Immune SA, a clinical stage biopharmaceutical company, discovers, designs, and develops medicines and diagnostic products for the prevention and treatment of neurodegenerative diseases associated with protein misfolding. Its SupraAntigen and Morphomer platforms are designed to generate vaccines, antibodies, and small molecules, which selectively interact with misfolded proteins that are common in a range of neurodegenerative diseases. The company is developing Crenezumab, a humanized, conformation-specific monoclonal antibody, which is in Phase II clinical prevention trial for the treatment of Alzheimer's disease (AD). It is also developing ACI-24, an anti-Abeta vaccine candidate that is in Phase II clinical study for AD, as well as completed Phase Ib clinical study for Down syndrome; ACI-35, an anti-Tau vaccine candidate that has completed Phase Ib clinical study; and Tau- positron emission tomography (PET) imaging tracer, which is in Phase II clinical study. In addition, the company is researching and developing small molecule Tau aggregation inhibitors for AD and NeuroOrphan indications. Further, it has discovery and preclinical stage molecules targeting range of neurodegenerative diseases, which include diagnostics targeting TDP-43, alpha-synuclein, and NLRP3. AC Immune SA has license agreements and collaborations with Genentech, Inc.; Biogen International GmbH; Janssen Pharmaceuticals, Inc.; Life Molecular Imaging SA; Eli Lilly and Company; and WuXi Biologics. The company was incorporated in 2003 and is headquartered in Lausanne, Switzerland.Show more
  • Revenue$4M-86.9%
  • EBITDA-$66M-32.1%
  • Net Income-$70M-38.4%
  • EPS (Diluted)-0.70-37.3%
  • Gross Margin100%+177.4%
  • EBITDA Margin-1857.26%-910.0%
  • Operating Margin-1927.32%-904.9%
  • Net Margin-1971.65%-957.5%
  • ROE-89.62%-140.2%

ACIU Price & Volume

AC Immune S.A. (ACIU) stock price & volume — 10-year historical chart

Loading chart...

Milestone Dependency Drives Persistent Clinical Burn Risk

Investment Thesis • Updated 2025Q4

VerdictNegative
Growth:Contracting
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Clinical Milestone Dependency

Key Thesis Takeaways

  • AC Immune remains a high-risk, clinical-stage biotechnology firm whose financial viability is tethered to the unpredictable timing of non-recurring milestone payments rather than sustainable commercial revenue.
  • While the company maintains a pipeline focused on neurodegenerative diseases, the persistent depletion of its capital base and the deepening accumulated deficit of $439.5 million underscore the significant long-term funding challenges ahead.
  • Investors should monitor the company's ability to secure non-dilutive capital or partnership inflows, as the current cash position of $26.8 million provides a limited runway for ongoing research operations.

Verdict Logic

the company's reliance on non-recurring revenue and a rapidly depleting cash balance of $26.8 million suggest a high probability of future dilutive financing to support its $10.5 million quarterly R&D burn rate.

ACIU Growth Metrics

AC Immune S.A. (ACIU) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-21.28%
5 Years-25.37%
3 Years-3.17%
TTM-86.92%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-38.36%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-37.25%

Return on Capital

10 Years-27.05%
5 Years-41.36%
3 Years-46.27%
Last Year-72.6%

ACIU Recent Earnings

AC Immune S.A. (ACIU) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 8/12 qtrs (67%)●Beat Revenue 8/12 qtrs (80%)
Q2 2026Latest
Apr 30, 2026
Metric
Actual
Est
EPS
$0.19+5.0%
$0.20
Rev
$1M+325.0%
$329,435
Q2 2026
Apr 29, 2026
Metric
Actual
Est
EPS
$0.19+5.0%
$0.20
Rev
$1M+325.0%
$329,435
Q2 2026
Mar 13, 2026
Metric
Actual
Est
EPS
$0.18+5.3%
$0.19
Rev
$428,876-70.3%
$1M
Q4 2025
Nov 4, 2025
Metric
Actual
Est
EPS
$0.20+9.1%
$0.22
Rev
$1M+3.2%
$1M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestApr 30, 2026
$0.19vs $0.20+5.0%
$1Mvs $329,435+325.0%
Q2 2026Apr 29, 2026
$0.19vs $0.20+5.0%
$1Mvs $329,435+325.0%
Q2 2026Mar 13, 2026
$0.18vs $0.19+5.3%
$428,876vs $1M-70.3%
Q4 2025Nov 4, 2025
$0.20vs $0.22+9.1%
$1Mvs $1M+3.2%
Based on last 12 quarters of dataView full earnings history →

Latest ACIU News

Recent stock market news and headlines for AC Immune S.A. (ACIU)

GlobeNewsWire·17h ago
AC Immune to Showcase Neurodegenerative Disease Pipeline with Three Presentations at AAIC® 2026

AC Immune to Showcase Neurodegenerative Disease Pipeline with Three Presentations at AAIC ® 2026 Lausanne, Switzerland, July 7, 2026 -- AC Immune SA (NASDAQ: ACIU), a clinical-stage biopharmaceutical company pioneering precision therapeutics for neurodegenerative diseases, today announces three presentations at the Alzheimer's Association International Conference® 2026, taking place July 12-15 in London, UK. Across these AAIC presentations, we are showing how AC Immune's Morphomer®-based small molecule approach has generated differentiated therapeutic and imaging assets.

GlobeNewsWire·Jun 30, 2026
AC Immune Reports Interim 12-Month Data from Phase 1b/2 ABATE Trial of ACI-24 in Prodromal Alzheimer's Disease

AC Immune Reports Interim 12-Month Data from Phase 1b/2 ABATE Trial of ACI-24 in Prodromal Alzheimer's Disease ACI-24 anti-Abeta active immunotherapy generally safe and well tolerated in first three Alzheimer's disease (AD) cohorts in ABATE Anti-Abeta antibody dose-response demonstrated with antibodies detected at all dose levels in cohorts AD1-3 Ongoing AD4 cohort includes additional adjuvant designed to enhance ACI-24 responses Lausanne, Switzerland, June 30, 2026 -- AC Immune SA (NASDAQ: ACIU), a clinical-stage biopharmaceutical company pioneering precision therapeutics for neurodegenerative diseases, today announced interim data from the first three cohorts (AD1, AD2 & AD3) of 74 patients with prodromal Alzheimer's disease (AD) in the Phase 1b/2 ABATE trial following 12 months of treatment with ACI-24 anti-amyloid beta (Abeta) active immunotherapy. In the trial to date, ACI-24 has been generally safe and well tolerated, with no evidence of amyloid-related imaging abnormalities-edema (ARIA-E).

Peers Comparison

Key metrics vs top competitors for AC Immune S.A. (ACIU)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ACIU logoACIUAC Immune S.A.Current
$2.54$258.5M-2.93-86.92%-1971.65%-89.62%—
PRAX logoPRAXPraxis Precision Medicines, Inc.
$323.95$9.36B-24.03-100%—-43.02%—
SAVA logoSAVACassava Sciences, Inc.
$1.32$63.77M-2.54——-95.77%—
ANVS logoANVSAnnovis Bio, Inc.
$1.92$37.77M-1.37——-318.08%—
NRXP logoNRXPNRx Pharmaceuticals, Inc.
$4.16$71.91M-3.10—-1070.26%——
BIIB logoBIIBBiogen Inc.
$205.70$30.37B23.301.39%13.92%7.55%—

Compare ACIU vs Peers

AC Immune S.A. (ACIU) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs PRAX

Most directly comparable listed peer for ACIU.

Scale Benchmark

vs LLY

Larger-name benchmark to compare ACIU against a more recognizable public peer.

Peer Set

Compare Top 5

vs PRAX, SAVA, ANVS, NRXP

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ACIU Frequently Asked Questions

AC Immune S.A. (ACIU) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is AC Immune S.A.'s revenue?

AC Immune S.A. (ACIU) reported $3.6M in revenue for fiscal year 2025. This represents a 59% decrease from $8.6M in 2013.

How fast is AC Immune S.A. growing?

AC Immune S.A. (ACIU) saw revenue decline by 86.9% over the past year.

Is ACIU profitable?

AC Immune S.A. (ACIU) reported a net loss of $70.4M for fiscal year 2025.

Dividend & Returns
What is ACIU's return on equity?

AC Immune S.A. (ACIU) has a return on equity (ROE) of -89.6%. Negative ROE indicates the company is unprofitable.

What is AC Immune S.A.'s free cash flow?

AC Immune S.A. (ACIU) had negative free cash flow of $70.1M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ACIU back in 2013?

Total return calculator · dividends reinvested · 13+ years of data

See returns →