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ACIUAC Immune S.A.
$2.54$259M
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  3. ACIU
  4. Financial Ratios

AC Immune S.A. (ACIU) Financial Ratios

Latest Ratios: P/E Ratio -2.9x · EV/EBITDA N/A · ROE -89.6%. (2013–2025 historical series)

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly

ACIU Valuation Multiples

Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Market Cap$259M$316M$269M$423M$170M$371M$372M$606M$584M$734M$650M
Enterprise Value$231M$294M$238M$348M$142M$292M$213M$415M$428M$610M$498M
P/E Ratio →-2.93——————13.31———
P/S Ratio58.3588.549.8628.6143.32—24.095.4881.2336.2528.01
P/B Ratio4.597.042.402.641.011.601.732.223.296.284.57
P/FCF——4.12————11.36———
P/OCF——4.09————10.97———

P/E links to full P/E history page with 30-year chart

ACIU EV Ratios

Enterprise-value multiples — capital-structure-neutral measures of total business value

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
EV / Revenue—82.318.7323.5436.00—13.813.7659.5530.1221.45
EV / EBITDA———————9.06———
EV / EBIT———————9.32———
EV / FCF——3.65————7.78———

ACIU Profitability

Margins and return-on-capital ratios measuring operating efficiency

Margins

Full margin charts and quarterly trend are on the Earnings History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Gross Margin100.0%100.0%-129.1%-268.9%100.0%—-285.5%54.3%-515.5%-61.3%-11.0%
Operating Margin-1927.3%-1927.3%-191.8%-362.3%-1800.4%—-397.0%40.3%-688.8%-111.3%-45.0%
Net Profit Margin-1971.6%-1971.6%-186.4%-366.4%-1798.0%—-401.3%41.1%-708.2%-130.4%-30.6%

Return on Capital

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
ROE-89.6%-89.6%-37.3%-32.9%-35.3%-32.6%-25.4%20.2%-34.6%-20.4%-6.6%
ROA-36.6%-36.6%-24.6%-29.4%-31.6%-29.2%-23.0%18.3%-31.0%-18.3%-6.0%
ROIC-99.2%-99.2%-47.0%-35.6%-36.3%-56.6%-66.3%64.6%-511.3%——
ROCE-72.6%-72.6%-35.0%-31.2%-34.1%-33.9%-24.2%19.1%-32.4%-16.8%-9.5%

ACIU Leverage & Debt

Solvency and debt-coverage ratios — lower is generally safer

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Debt / Equity0.100.100.050.020.020.010.010.010.000.00—
Debt / EBITDA———————0.06———
Net Debt / Equity—-0.50-0.27-0.47-0.17-0.34-0.74-0.70-0.88-1.06-1.07
Net Debt / EBITDA———————-4.16———
Debt / FCF——-0.47————-3.58———
Interest Coverage-367.83-367.83-381.80-307.09-198.27-124.63-332.9323.12-151.55-178.67-27.69

Net cash position: cash ($27M) exceeds total debt ($5M)

ACIU Liquidity & Efficiency

Short-term solvency ratios and asset-utilisation metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Current Ratio1.021.021.719.2211.1610.1216.5316.7214.7513.2815.61
Quick Ratio1.021.021.719.2211.1610.1216.5316.7214.7513.4215.57
Cash Ratio0.970.971.647.5910.689.9016.1116.4814.2512.7515.34
Asset Turnover—0.020.120.080.02—0.060.370.040.150.15
Inventory Turnover——————————66.26
Days Sales Outstanding—69.6514.69371.0437.84—37.634.62208.1266.9822.11

ACIU Shareholder Yields

Earnings, FCF, buyback, and dividend yields — total returns to shareholders

Dividends

Full dividend history and growth charts are on the Dividend History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Dividend Yield———————————
Payout Ratio———————————

Total Shareholder Return Metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Earnings Yield———————7.5%———
FCF Yield——24.2%————8.8%———
Buyback Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%
Total Shareholder Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%
Shares Outstanding—$101M$100M$85M$84M$75M$72M$71M$62M$57M$50M

Key Metrics

Growth RegimeContracting
ProfitabilityNegative
Balance SheetVulnerable
Cash FlowBurning
Top Statement Risk

Clinical Milestone Dependency

Speculative Premium Amidst Revenue Contraction

According to current market data, ACIU trades at a P/S multiple of 59.03, a valuation that appears disconnected from the company's 86.92% year-over-year revenue decline and suggests investors are pricing the stock as a high-stakes call option on future clinical trial success rather than fundamental performance.

The elevated P/S ratio reflects the market's willingness to assign value to the underlying intellectual property and vaccine platform despite the absence of recurring revenue. This valuation implies that the market anticipates a significant, non-linear value inflection point, likely tied to upcoming clinical readouts, which may render traditional valuation metrics largely irrelevant in the near term.

Persistent Capital Erosion and Decay

As reported in recent financial statements, the company's ROIC has deteriorated to -34.8% in 2025Q4, illustrating a consistent trend of value destruction as the firm continues to deploy capital into high-cost research initiatives that have yet to generate a sustainable return on invested capital.

The negative ROIC trend highlights the inherent difficulty of compounding capital in a pre-revenue biotech model where R&D expenditures are mandatory and success is binary. Investors should monitor whether future milestone payments can offset this structural decay, though current figures suggest that the company is currently consuming rather than creating shareholder value.

Liquidity Buffer Nearing Critical Thresholds

Based on the latest quarterly data, AC Immune's current ratio has compressed to 1.02 as of 2025Q4, a significant decline from the 9.22 ratio observed in 2023Q4, indicating that the company's immediate liquidity buffer is rapidly diminishing relative to its short-term operational obligations.

This compression suggests that the company's ability to withstand operational stress without external financing is severely limited. The rapid shift in liquidity ratios warrants close investigation, as it may indicate an impending need for capital markets access to sustain the current research pipeline.

Misapplication of P/E Multiples

The P/E ratio is the most commonly misapplied metric for AC Immune, as the company's negative earnings and milestone-driven revenue model render traditional price-to-earnings analysis fundamentally misleading for assessing the firm's true economic potential or operational health.

Using P/E to evaluate a clinical-stage biotech obscures the reality that earnings are currently a function of accounting recognition rather than operational profitability. Analysts should instead focus on cash burn rates and the probability-weighted net present value of the clinical pipeline to better understand the company's actual risk-reward profile.

Download Financial Ratios Data

Includes 30+ ratios · 13 years · Updated daily

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ACIU — Frequently Asked Questions

Quick answers to the most common questions about buying ACIU stock.

What is AC Immune S.A.'s P/E ratio?

AC Immune S.A.'s current P/E ratio is -2.9x. The historical average is 13.3x.

What is AC Immune S.A.'s ROE?

AC Immune S.A.'s return on equity (ROE) is -89.6%. The historical average is -35.3%.

Is ACIU stock overvalued?

Based on historical data, AC Immune S.A. is trading at a P/E of -2.9x. Compare with industry peers and growth rates for a complete picture.

What are AC Immune S.A.'s profit margins?

AC Immune S.A. has 100.0% gross margin and -1927.3% operating margin.