Latest Ratios: P/E Ratio -2.9x · EV/EBITDA N/A · ROE -89.6%. (2013–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $259M | $316M | $269M | $423M | $170M | $371M | $372M | $606M | $584M | $734M | $650M |
| Enterprise Value | $231M | $294M | $238M | $348M | $142M | $292M | $213M | $415M | $428M | $610M | $498M |
| P/E Ratio → | -2.93 | — | — | — | — | — | — | 13.31 | — | — | — |
| P/S Ratio | 58.35 | 88.54 | 9.86 | 28.61 | 43.32 | — | 24.09 | 5.48 | 81.23 | 36.25 | 28.01 |
| P/B Ratio | 4.59 | 7.04 | 2.40 | 2.64 | 1.01 | 1.60 | 1.73 | 2.22 | 3.29 | 6.28 | 4.57 |
| P/FCF | — | — | 4.12 | — | — | — | — | 11.36 | — | — | — |
| P/OCF | — | — | 4.09 | — | — | — | — | 10.97 | — | — | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 82.31 | 8.73 | 23.54 | 36.00 | — | 13.81 | 3.76 | 59.55 | 30.12 | 21.45 |
| EV / EBITDA | — | — | — | — | — | — | — | 9.06 | — | — | — |
| EV / EBIT | — | — | — | — | — | — | — | 9.32 | — | — | — |
| EV / FCF | — | — | 3.65 | — | — | — | — | 7.78 | — | — | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 100.0% | 100.0% | -129.1% | -268.9% | 100.0% | — | -285.5% | 54.3% | -515.5% | -61.3% | -11.0% |
| Operating Margin | -1927.3% | -1927.3% | -191.8% | -362.3% | -1800.4% | — | -397.0% | 40.3% | -688.8% | -111.3% | -45.0% |
| Net Profit Margin | -1971.6% | -1971.6% | -186.4% | -366.4% | -1798.0% | — | -401.3% | 41.1% | -708.2% | -130.4% | -30.6% |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -89.6% | -89.6% | -37.3% | -32.9% | -35.3% | -32.6% | -25.4% | 20.2% | -34.6% | -20.4% | -6.6% |
| ROA | -36.6% | -36.6% | -24.6% | -29.4% | -31.6% | -29.2% | -23.0% | 18.3% | -31.0% | -18.3% | -6.0% |
| ROIC | -99.2% | -99.2% | -47.0% | -35.6% | -36.3% | -56.6% | -66.3% | 64.6% | -511.3% | — | — |
| ROCE | -72.6% | -72.6% | -35.0% | -31.2% | -34.1% | -33.9% | -24.2% | 19.1% | -32.4% | -16.8% | -9.5% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.10 | 0.10 | 0.05 | 0.02 | 0.02 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | — |
| Debt / EBITDA | — | — | — | — | — | — | — | 0.06 | — | — | — |
| Net Debt / Equity | — | -0.50 | -0.27 | -0.47 | -0.17 | -0.34 | -0.74 | -0.70 | -0.88 | -1.06 | -1.07 |
| Net Debt / EBITDA | — | — | — | — | — | — | — | -4.16 | — | — | — |
| Debt / FCF | — | — | -0.47 | — | — | — | — | -3.58 | — | — | — |
| Interest Coverage | -367.83 | -367.83 | -381.80 | -307.09 | -198.27 | -124.63 | -332.93 | 23.12 | -151.55 | -178.67 | -27.69 |
Net cash position: cash ($27M) exceeds total debt ($5M)
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 1.02 | 1.02 | 1.71 | 9.22 | 11.16 | 10.12 | 16.53 | 16.72 | 14.75 | 13.28 | 15.61 |
| Quick Ratio | 1.02 | 1.02 | 1.71 | 9.22 | 11.16 | 10.12 | 16.53 | 16.72 | 14.75 | 13.42 | 15.57 |
| Cash Ratio | 0.97 | 0.97 | 1.64 | 7.59 | 10.68 | 9.90 | 16.11 | 16.48 | 14.25 | 12.75 | 15.34 |
| Asset Turnover | — | 0.02 | 0.12 | 0.08 | 0.02 | — | 0.06 | 0.37 | 0.04 | 0.15 | 0.15 |
| Inventory Turnover | — | — | — | — | — | — | — | — | — | — | 66.26 |
| Days Sales Outstanding | — | 69.65 | 14.69 | 371.04 | 37.84 | — | 37.63 | 4.62 | 208.12 | 66.98 | 22.11 |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | — | — | — | — | 7.5% | — | — | — |
| FCF Yield | — | — | 24.2% | — | — | — | — | 8.8% | — | — | — |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Shares Outstanding | — | $101M | $100M | $85M | $84M | $75M | $72M | $71M | $62M | $57M | $50M |
Clinical Milestone Dependency
According to current market data, ACIU trades at a P/S multiple of 59.03, a valuation that appears disconnected from the company's 86.92% year-over-year revenue decline and suggests investors are pricing the stock as a high-stakes call option on future clinical trial success rather than fundamental performance.
The elevated P/S ratio reflects the market's willingness to assign value to the underlying intellectual property and vaccine platform despite the absence of recurring revenue. This valuation implies that the market anticipates a significant, non-linear value inflection point, likely tied to upcoming clinical readouts, which may render traditional valuation metrics largely irrelevant in the near term.
As reported in recent financial statements, the company's ROIC has deteriorated to -34.8% in 2025Q4, illustrating a consistent trend of value destruction as the firm continues to deploy capital into high-cost research initiatives that have yet to generate a sustainable return on invested capital.
The negative ROIC trend highlights the inherent difficulty of compounding capital in a pre-revenue biotech model where R&D expenditures are mandatory and success is binary. Investors should monitor whether future milestone payments can offset this structural decay, though current figures suggest that the company is currently consuming rather than creating shareholder value.
Based on the latest quarterly data, AC Immune's current ratio has compressed to 1.02 as of 2025Q4, a significant decline from the 9.22 ratio observed in 2023Q4, indicating that the company's immediate liquidity buffer is rapidly diminishing relative to its short-term operational obligations.
This compression suggests that the company's ability to withstand operational stress without external financing is severely limited. The rapid shift in liquidity ratios warrants close investigation, as it may indicate an impending need for capital markets access to sustain the current research pipeline.
The P/E ratio is the most commonly misapplied metric for AC Immune, as the company's negative earnings and milestone-driven revenue model render traditional price-to-earnings analysis fundamentally misleading for assessing the firm's true economic potential or operational health.
Using P/E to evaluate a clinical-stage biotech obscures the reality that earnings are currently a function of accounting recognition rather than operational profitability. Analysts should instead focus on cash burn rates and the probability-weighted net present value of the clinical pipeline to better understand the company's actual risk-reward profile.
Includes 30+ ratios · 13 years · Updated daily
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Quick answers to the most common questions about buying ACIU stock.
AC Immune S.A.'s current P/E ratio is -2.9x. The historical average is 13.3x.
AC Immune S.A.'s return on equity (ROE) is -89.6%. The historical average is -35.3%.
Based on historical data, AC Immune S.A. is trading at a P/E of -2.9x. Compare with industry peers and growth rates for a complete picture.
AC Immune S.A. has 100.0% gross margin and -1927.3% operating margin.