Persistent negative free cash flow, which totaled $6.0M in 2025Q4, underscores the company's reliance on external capital to fund its clinical operations.
| Metric | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 | Dec'03 | Dec'02 | Dec'01 | Dec'00 | Dec'99 | Dec'98 |
|---|
| Cash from Operations | -12.85M | -1.22M | -12.42M | -15.99M | -16.13M | -8.76M | -5.29M | -4.6M | -5.68M | -5.62M | -5.7M | -2.31M | -97.13K | -227.89K | -881.91K | -407.86K | -535.42K | -959.8K | -2.15M | -1.96M | -1.18M | -1.72M | -1.52M | -1.57M | -2.46M | -2.19M | -527K | -310K |
| Operating CF Margin % | - | - | - | - | - | - | - | - | - | - | - | - | -3237.63% | - | 1075.5% | -217.71% | -956.11% | -1043.26% | -3359.06% | -484.71% | -1020.4% | -1737.37% | - | - | - | - | - | - |
| Operating CF Growth % | -953.54% | 90.18% | 22.31% | 0.88% | -84.22% | -65.48% | -15.09% | 19.06% | -1.16% | 1.43% | -146.28% | -2281.52% | 57.38% | 74.16% | -116.23% | 23.82% | 44.22% | 55.35% | -9.51% | -65.85% | 31.18% | -12.86% | 2.99% | 36.03% | -11.99% | -316.13% | -70% | - |
| Net Income | -18.43M | -9.48M | -14M | -12.55M | -17.36M | -19.17M | -7.26M | -7.93M | -6.57M | -7.92M | -8.92M | -3.41M | -272.15K | -644.21K | -298.8K | -1.12M | -708.47K | -1.5M | -2.43M | -2.08M | -2.26M | -1.39M | -1.96M | -2.31M | -2.33M | -2.27M | -554K | -272K |
| Depreciation & Amortization | 234K | 99.09K | 75.97K | 41.57K | 104.52K | 65.93K | 194.77K | 15.99K | 10.68K | 8.79K | 0 | 0 | 0 | 0 | 0 | 212.49K | 231.75K | 315.66K | 59.61K | 127.26K | 134.18K | 20K | 32K | 21K | 20K | 25K | 1K | 1K |
| Stock-Based Compensation | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Deferred Taxes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | 2.29M | 8.6M | 2.75M | -2.53M | 1.7M | 10.56M | 1.55M | 1.37M | -895.98K | 1.35M | 3.32M | 893.06K | 85.59K | 380.81K | -366K | 384.38K | 62.65K | -67.6K | 441.1K | -6.36K | 23.48K | -115K | 742K | 655K | -89K | -85K | -1K | 0 |
| Working Capital Changes | 3.06M | -441.1K | -1.25M | -948.89K | -573.01K | -215.69K | 223.59K | 1.94M | 1.78M | 951.66K | -93.05K | 205.06K | 89.44K | 35.52K | -217.12K | 111.05K | -121.35K | 296.63K | -219.02K | 686 | 916.02K | -237K | -336K | 59K | -62K | 135K | 27K | -39K |
| Change in Receivables | -692K | -1.11M | -1.14M | -127.17K | 317.27K | -342.85K | -99.37K | -179.87K | 38.83K | 0 | -158.18K | -93.3K | -41.35K | 0 | 0 | -5.57K | 6.33K | 132.29K | 16.84K | -1.85K | 877.19K | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 27.66K | -9.36K | -22K | 13K | -15.19K | -4K | -1K | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 298.37K | 130.79K | 0 | 0 | 88.95K | -118.31K | 187.41K | -249.42K | 17.72K | 42.82K | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cash from Investing | 3.04M | -56.73K | -991.57K | -3.26M | 96.36K | -93.25K | -2.98K | 0 | -970 | -276.93K | 0 | 65.62K | 1.92K | 133.18K | -655.49K | -102.12K | -41.63K | -116.77K | -70.75K | -120.95K | -112.37K | -53K | -394K | 870K | 997K | -2.36M | -271K | -128K |
| Capital Expenditures | -21K | -15.18K | 0 | 0 | -16.31K | -93.25K | -2.98K | 0 | -970 | -38.46K | 0 | 0 | 0 | 0 | 0 | -102.12K | -41.63K | -116.77K | -70.75K | -100.49K | -112.37K | -71K | -50K | -80K | -131K | -313K | -271K | -128K |
| CapEx % of Revenue | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 54.51% | 74.33% | 126.93% | 110.55% | 24.81% | 96.87% | 71.72% | - | - | - | - | - | - |
| Acquisitions | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 65.62K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -21K | 0 | -188K | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | 3.06M | 10.45K | -200.21K | -1.08M | 112.67K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -88.79K | -146.27K | 0 | 0 | 0 | 0 | 537 | 0 | 206K | -294K | 950K | 1.13M | -2.05M | 0 | 0 |
| Cash from Financing | 10.01M | 3.6M | 31.65K | -44.84K | -17.05K | 54.12M | 1.31M | 10.08M | 1.16M | 1.28M | 12.56M | 4.57M | 150.02K | 66.1K | 1.57M | 558.48K | 585.12K | 484.35K | 2.32M | 1.67M | 1.48M | 1.65M | 2.04M | 488K | 1.28M | 4.73M | 392K | 1M |
| Debt Issued (Net) | 0 | -141K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 779.13K | 10.58M | 2.52M | 0 | 0 | 0 | 0 | 0 | 1.25K | 0 | 0 | -24.46K | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Equity Issued (Net) | 10.2M | 3.71M | 125.83K | 0 | 95.62K | 54.32M | 1.46M | 10.08M | 1.16M | 497.81K | 2.73M | 2.05M | 150.02K | 66.1K | 1.57M | 558.48K | 585.12K | 483.09K | 2.32M | 1.67M | 1.5M | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | -196K | 28.33K | -94.17K | -44.84K | -112.67K | -203.45K | -156.02K | 0 | 0 | 0 | -750.61K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.65M | 2.04M | 488K | 1.28M | 4.73M | 392K | 1M |
| Net Change in Cash | 286K | 2.03M | -13.4M | -19.62M | -17.59M | 48.26M | -3.97M | 5.24M | -4.33M | -5.95M | 6.49M | 2.14M | 58.16K | -26.91K | -38.02K | 38.53K | 8.02K | -651.02K | 88.38K | -323.71K | 937.97K | -910K | -762K | -626K | -178K | 171K | -406K | 563K |
| Free Cash Flow | -12.87M | -1.23M | -12.42M | -15.99M | -16.15M | -8.76M | -5.29M | -4.6M | -5.68M | -5.65M | -5.7M | -2.31M | -97.13K | -227.89K | -881.91K | -474.85K | -535.42K | -959.8K | -2.15M | -1.98M | -1.2M | -1.79M | -1.57M | -1.65M | -2.59M | -2.51M | -798K | -438K |
| FCF Margin % | - | - | - | - | - | - | - | - | - | - | - | - | -3237.6% | - | 1075.5% | -253.47% | -956.11% | -1043.26% | -3360.18% | -487.72% | -1030.23% | -1809.09% | - | - | - | - | - | - |
| FCF Growth % | -942.29% | 90.06% | 22.31% | 0.98% | -84.36% | -65.43% | -15.15% | 19.07% | -0.49% | 0.75% | -146.28% | -2281.54% | 57.38% | 74.16% | -85.72% | 11.31% | 44.22% | 55.37% | -8.87% | -65.29% | 33.27% | -13.79% | 4.66% | 36.18% | -3.23% | -214.04% | -82.19% | - |
| FCF per Share | -0.22 | -0.02 | -0.24 | -0.31 | -0.33 | -0.18 | -0.08 | -0.07 | -0.10 | -0.11 | -0.12 | -0.40 | -0.01 | -0.25 | -1.34 | -1.36 | -5.17 | -29.34 | -121.72 | -155.67 | -146.58 | -323.69 | -336.47 | -717.20 | -2470.87 | -3059.83 | -961.45 | -510.49 |
| FCF Conversion (FCF/Net Income) | 0.70x | 0.10x | 0.56x | 0.84x | 0.51x | 0.25x | 0.57x | 0.58x | 0.84x | 0.78x | 0.66x | 0.66x | 0.35x | 0.27x | 1.13x | 0.13x | 0.73x | 0.67x | 0.89x | 0.90x | 0.55x | 1.24x | 0.78x | 0.68x | 1.06x | 0.97x | 0.95x | 1.14x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Imminent liquidity and dilution
As reported in financial statements, Tiziana Life Sciences exhibits a volatile relationship between net income and operating cash flow, with the OCF/NI ratio fluctuating significantly from 0.21 to 1.79 over the last ten quarters, suggesting that accruals and non-cash adjustments heavily influence the reported bottom-line figures.
The lack of a consistent correlation between net losses and cash outflows indicates that the company's reported net income is a poor proxy for its actual liquidity requirements. Investors should monitor these swings as they likely reflect the timing of clinical trial payments and vendor accruals rather than underlying operational efficiency.
Based on recent SEC filings, Tiziana Life Sciences has consistently generated negative free cash flow, with the most recent quarter showing a $6.0M outflow, confirming that the company remains in a capital-intensive phase without any internal cash generation to offset its ongoing research and development expenditures.
The persistent negative FCF trajectory underscores the firm's total reliance on external financing to sustain its clinical pipeline. Without a shift toward milestone-based revenue or a strategic partnership, the current burn rate appears unsustainable, necessitating frequent capital market access that may continue to dilute existing shareholders.
According to historical data, working capital changes have been highly erratic, swinging from a $4.8M inflow in 2025Q4 to a $4.1M outflow in 2023Q2, which suggests that the company's cash position is sensitive to the timing of clinical trial-related payables and potential shifts in vendor credit terms.
These fluctuations in working capital appear to be the primary mechanism for managing short-term liquidity in the absence of revenue. Analysts should interpret these swings as evidence of management's efforts to stretch cash runway by timing payments to contract research organizations and other clinical service providers.
As indicated by the company's reported figures, capital deployment has been almost exclusively directed toward sustaining clinical operations, with negligible spending on non-core activities and a complete absence of dividends or share repurchases since the 2022 period, reflecting a management team focused entirely on preserving cash.
The cessation of share buybacks observed in earlier periods suggests a strategic pivot toward prioritizing clinical trial funding over capital return initiatives. This shift appears necessary given the company's precarious cash position, though it highlights the lack of financial flexibility currently available to the firm.
Quick answers to the most common questions about buying TLSA stock.
Tiziana Life Sciences Ltd (TLSA) generated $-12.8M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
Tiziana Life Sciences Ltd (TLSA) reported negative free cash flow of $12.9M in 2025, indicating capital requirements exceeded cash from operations.
Tiziana Life Sciences Ltd (TLSA) spent $0.0M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.