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SYBXSynlogic, Inc.
$0.70$8M
Overview & Verdict
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SYBX logoSynlogic, Inc.(SYBX)Earnings, Financials & Key Ratios

SYBX•NASDAQ
$0.70
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryMicrobiome and Phage Therapeutics
AboutSynlogic, Inc., a clinical-stage biopharmaceutical company, engages in the discovery and development of synthetic biotic medicines to treat metabolic and immunological diseases in the United States. Its therapeutic programs include SYNB1618 and SYNB1934 that are orally administered, non-systemically absorbed drug candidates, which are in Phase II clinical trials to treat phenylketonuria; SYNB1353, an orally administered, non-systemically absorbed drug candidate to treat homocystinuria; and SYNB8802, an orally administered, non-systemically absorbed drug candidate that is in Phase I clinical trial for the treatment of enteric hyperoxaluria. The company is also developing SYNB1891, an intratumorally administered synthetic biotic medicine that is in Phase I clinical trial to treat solid tumors and lymphoma. It has a collaboration agreement with F. Hoffmann-La Roche Ltd; Hoffmann-La Roche Inc.; and Ginkgo Bioworks, Inc. Synlogic, Inc. is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$0-100.0%
  • EBITDA-$4M+91.1%
  • Net Income-$1M+95.7%
  • EPS (Diluted)-0.08+95.8%
  • ROE-8.17%+90.3%

SYBX Price & Volume

Synlogic, Inc. (SYBX) stock price & volume — 10-year historical chart

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Operational Wind-down Masks Severe Capital Erosion Risks

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Contracting
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Total cessation of operations

Key Thesis Takeaways

  • Synlogic has effectively ceased all core clinical operations, transitioning into a terminal wind-down phase characterized by zero revenue generation and a rapidly depleting asset base.
  • The company's historical reliance on milestone payments has vanished, leaving shareholders exposed to significant liquidation risks as the firm manages residual liabilities.
  • Investors should exercise extreme caution, as the reported $14.1 million cash position may be insufficient to cover undisclosed termination fees and ongoing administrative costs.

Verdict Logic

the company's accumulated deficit of $442.0 million and the total cessation of revenue suggest that the remaining $14.1 million in cash is likely to be consumed by wind-down liabilities rather than returned to shareholders.

SYBX Growth Metrics

Synlogic, Inc. (SYBX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-125%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-145.6%

Return on Capital

10 Years-52.59%
5 Years-63.31%
3 Years-74.96%
Last Year-32.57%

Peers Comparison

Key metrics vs top competitors for Synlogic, Inc. (SYBX)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
SYBX logoSYBXSynlogic, Inc.Current
$0.70$8.2M-8.76-100%—-8.17%—
IMVT logoIMVTImmunovant, Inc.
$40.09$8.23B-14.47——-68.16%—
ACMR logoACMRACM Research, Inc.
$94.66$6.27B69.0915.24%9.48%5.13%—
AGEN logoAGENAgenus Inc.
$3.50$145.75M-1029.4110.37%52.16%——
NKTR logoNKTRNektar Therapeutics
$74.90$1.46B-7.70-43.89%-284.18%-87%—
MIRM logoMIRMMirum Pharmaceuticals, Inc.
$128.31$6.44B-273.0054.74%-194.97%-289.33%—

Compare SYBX vs Peers

Synlogic, Inc. (SYBX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IMVT

Most directly comparable listed peer for SYBX.

Scale Benchmark

vs TMO

Larger-name benchmark to compare SYBX against a more recognizable public peer.

Peer Set

Compare Top 5

vs IMVT, ACMR, AGEN, NKTR

SYBX SEC Filings & Documents

Synlogic, Inc. (SYBX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Jan 20, 2026·SEC

Material company update

Dec 16, 2025·SEC

Material company update

Nov 26, 2025·SEC

10-K Annual Reports

4
FY 2026

Mar 12, 2026·SEC

FY 2025

Mar 6, 2025·SEC

FY 2024

Mar 19, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 14, 2026·SEC

FY 2025

Nov 13, 2025·SEC

FY 2025

Aug 7, 2025·SEC

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SYBX Frequently Asked Questions

Synlogic, Inc. (SYBX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
How fast is Synlogic, Inc. growing?

Synlogic, Inc. (SYBX) saw revenue decline by 100.0% over the past year.

Is SYBX profitable?

Synlogic, Inc. (SYBX) reported a net loss of $0.6M for fiscal year 2025.

Dividend & Returns
What is SYBX's return on equity?

Synlogic, Inc. (SYBX) has a return on equity (ROE) of -8.2%. Negative ROE indicates the company is unprofitable.

What is Synlogic, Inc.'s free cash flow?

Synlogic, Inc. (SYBX) had negative free cash flow of $3.3M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in SYBX back in 2013?

Total return calculator · dividends reinvested · 13+ years of data

See returns →