Latest Ratios: P/E Ratio -8.8x · EV/EBITDA N/A · ROE -8.2%. (2013–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $8M | $14M | $17M | $25M | $54M | $134M | $77M | $78M | $167M | $65M | $562M |
| Enterprise Value | $-6468655 | $-878662 | $-1785307 | $18M | $59M | $138M | $68M | $77M | $157M | $-20936422 | $547M |
| P/E Ratio → | -8.76 | — | — | — | — | — | — | — | — | — | — |
| P/S Ratio | — | — | 2134.34 | 7.43 | 46.16 | 76.30 | 141.94 | 35.11 | 66.40 | 26.68 | 1266.33 |
| P/B Ratio | 0.73 | 1.16 | 1.34 | 0.59 | 0.66 | 0.91 | 0.67 | 0.50 | 1.35 | 0.77 | 9.32 |
| P/FCF | — | — | — | — | — | — | — | — | — | — | — |
| P/OCF | — | — | — | — | — | — | — | — | — | — | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | — | -223.16 | 5.44 | 49.92 | 78.67 | 124.14 | 34.59 | 62.13 | -8.57 | 1231.69 |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — | — |
| EV / FCF | — | — | — | — | — | — | — | — | — | — | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | — | — | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | -491.2% | 100.0% | 64.2% |
| Operating Margin | — | — | -511875.0% | -1636.3% | -5713.5% | -3464.4% | -11094.7% | -2446.4% | -2032.9% | -1670.4% | -5995.0% |
| Net Profit Margin | — | — | -291987.5% | -1699.3% | -5605.7% | -3452.7% | -10857.4% | -2309.9% | -1922.0% | -1652.1% | -5916.2% |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -8.2% | -8.2% | -84.3% | -91.5% | -57.6% | -46.2% | -43.5% | -36.6% | -46.3% | -55.5% | -36.1% |
| ROA | -5.7% | -5.7% | -49.0% | -61.5% | -46.3% | -38.0% | -35.6% | -31.2% | -40.4% | -49.3% | -33.9% |
| ROIC | — | — | -205.7% | -67.3% | -42.4% | -35.5% | -34.7% | -30.3% | -68.5% | -139.6% | -99.1% |
| ROCE | -32.6% | -32.6% | -120.6% | -71.7% | -51.2% | -40.5% | -38.4% | -34.9% | -46.0% | -53.7% | -36.4% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | — | — | — | 0.40 | 0.25 | 0.14 | 0.20 | 0.16 | 0.00 | 0.01 | 0.02 |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | -1.24 | -1.48 | -0.16 | 0.05 | 0.03 | -0.08 | -0.01 | -0.09 | -1.01 | -0.25 |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| Debt / FCF | — | — | — | — | — | — | — | — | — | — | — |
| Interest Coverage | — | — | — | -57267.00 | -33072.50 | -30279.50 | -9861.17 | -2445.33 | -1125.40 | -707.37 | — |
Net cash position: cash ($15M) exceeds total debt ($0)
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 4.30 | 4.30 | 2.80 | 2.45 | 6.58 | 13.23 | 12.87 | 15.03 | 14.71 | 9.64 | 22.23 |
| Quick Ratio | 4.30 | 4.30 | 2.80 | 2.45 | 6.58 | 13.23 | 12.87 | 15.03 | 14.71 | 9.64 | 22.23 |
| Cash Ratio | 4.09 | 4.09 | 2.67 | 2.34 | 6.40 | 12.76 | 12.10 | 13.49 | 14.71 | 9.64 | 21.91 |
| Asset Turnover | — | — | 0.00 | 0.04 | 0.01 | 0.01 | 0.00 | 0.01 | 0.02 | 0.02 | 0.01 |
| Inventory Turnover | — | — | — | — | — | — | — | — | — | — | — |
| Days Sales Outstanding | — | — | — | — | — | — | — | — | — | — | — |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | — | — | — | — | — | — | — | — |
| FCF Yield | — | — | — | — | — | — | — | — | — | — | — |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 4.6% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 4.6% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Shares Outstanding | — | $12M | $12M | $7M | $5M | $4M | $2M | $2M | $2M | $448309 | $3M |
Total cessation of operations
According to recent market data, Synlogic trades at a price-to-book ratio of 0.63, which, based on reported figures, suggests that investors are pricing the company below its stated net asset value in anticipation of further erosion during the ongoing wind-down process.
The negative P/E ratio of -7.64 is largely irrelevant given the company's lack of commercial revenue and the discontinuation of its primary clinical programs. This valuation implies that the market views the remaining cash balance as the only tangible asset, while discounting the potential for significant liabilities to emerge during the final dissolution.
As reported in financial statements, the company's ROIC reached a low of -40.7% in 2024Q1, illustrating a long-term trend of capital destruction that has rendered the firm unable to generate positive returns on its invested capital prior to the recent strategic pivot.
The erratic fluctuations in ROE, which swung from -112.8% to 21.0% in recent periods, appear to be driven by accounting adjustments rather than operational success. This volatility confirms that the company's historical capital allocation failed to build a sustainable business, leaving no foundation for future compounding.
Based on quarterly filings, the company maintains a current ratio of 7.08 as of 2026Q1, yet this figure is misleading because it does not account for the substantial clinical trial termination fees and severance costs that will likely consume the remaining cash reserves.
While the high current ratio suggests a strong short-term position, the lack of any incoming revenue streams means that this liquidity is strictly finite. Investors should monitor the rate of cash depletion, as the current ratio will likely deteriorate rapidly as the company settles its final operational liabilities.
The most commonly misapplied metric for Synlogic is the price-to-book ratio, which, as indicated by historical data, obscures the reality that the company's book value is heavily comprised of assets that may be subject to significant impairment during a formal liquidation process.
Analysts should instead focus on a 'net cash' analysis, which subtracts all potential wind-down liabilities from the reported cash balance to determine a more realistic floor for shareholder value. Relying on book value ignores the high probability that the company's remaining assets will be liquidated at a substantial discount to their carrying value.
Includes 30+ ratios · 13 years · Updated daily
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Quick answers to the most common questions about buying SYBX stock.
Synlogic, Inc.'s current P/E ratio is -8.8x. This places it at the 50th percentile of its historical range.
Synlogic, Inc.'s return on equity (ROE) is -8.2%. The historical average is -58.2%.
Based on historical data, Synlogic, Inc. is trading at a P/E of -8.8x. This is at the 50th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.