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SPRBSpruce Biosciences, Inc.
$51.85$71M
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SPRB logoSpruce Biosciences, Inc.(SPRB)Earnings, Financials & Key Ratios

SPRB•NASDAQ
$51.85
Price updated Jul 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Rare Disease Biopharma
AboutSpruce Biosciences, Inc., a biopharmaceutical company, focuses on developing and commercializing novel therapies for rare endocrine disorders. The company engages in developing tildacerfont, a non-steroidal therapy to enhance disease control and reduce steroid burden for adult patients suffering from congenital adrenal hyperplasia (CAH), which is in Phase 2b clinical trial; and to evaluate glucocorticoid reduction and clinical consequences in adult patients with classic CAH that is Phase 2b clinical trial. It is also developing tildacerfont for the treatment of pediatric classic congenital adrenal hyperplasia in children that is in Phase 2 clinical trial; and for females with polycystic ovary syndrome, which is in Phase 2 clinical trial. The company has a license agreement with Eli Lilly and Company to research, develop, and commercialize compounds for various pharmaceutical uses. Spruce Biosciences, Inc. was incorporated in 2014 and is headquartered in Daly City, California.Show more
  • Revenue$0-100.0%
  • EBITDA-$36M+35.0%
  • Net Income-$39M+26.5%
  • EPS (Diluted)-50.83+47.5%
  • ROE-109.24%-8.5%

SPRB Price & Volume

Spruce Biosciences, Inc. (SPRB) stock price & volume — 10-year historical chart

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Clinical Setbacks Drive Severe Revenue Erosion Risks

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Contracting
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Clinical trial failure risk

Key Thesis Takeaways

  • Spruce Biosciences faces a precarious outlook as it transitions back to a pre-revenue development stage following the collapse of quarterly revenue from $2.9 million in 2023Q4 to zero.
  • The company's reliance on external capital is underscored by a persistent net loss of $12.3 million in 2026Q1, which continues to erode shareholder equity, now down to $34.6 million.
  • Investors should monitor the company's ability to manage its remaining $54.1 million in cash reserves against the high-stakes R&D requirements necessary to reach future clinical milestones.

Verdict Logic

the company's precarious liquidity position, evidenced by a $12.3 million net loss in 2026Q1 and the absence of revenue, suggests substantial risk to future viability without additional capital raises.

SPRB Growth Metrics

Spruce Biosciences, Inc. (SPRB) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-100%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM32.93%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM62.59%

Return on Capital

10 Years-242.2%
5 Years-70.31%
3 Years-90.3%
Last Year-100.18%

SPRB Recent Earnings

Spruce Biosciences, Inc. (SPRB) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 10/12 qtrs (83%)●Beat Revenue 6/12 qtrs (86%)
Q2 2026Latest
May 13, 2026
Metric
Actual
Est
EPS
$8.94-12.7%
$7.93
Rev
—
—
Q2 2026
Mar 9, 2026
Metric
Actual
Est
EPS
$9.58+25.6%
$12.87
Rev
—
$500,000
Q4 2025
Nov 10, 2025
Metric
Actual
Est
EPS
$14.58+6.3%
$15.56
Rev
—
—
Q3 2025
Aug 14, 2025
Metric
Actual
Est
EPS
$3.50+80.6%
$18.05
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 13, 2026
$8.94vs $7.93-12.7%
—
Q2 2026Mar 9, 2026
$9.58vs $12.87+25.6%
—vs $500,000
Q4 2025Nov 10, 2025
$14.58vs $15.56+6.3%
—
Q3 2025Aug 14, 2025
$3.50vs $18.05+80.6%
—
Based on last 12 quarters of dataView full earnings history →

Latest SPRB News

Recent stock market news and headlines for Spruce Biosciences, Inc. (SPRB)

Business Wire·Jun 29, 2026
Spruce Biosciences Joins the Russell 3000® Index

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced that it has been added as a member of the Russell 3000® Index, effective with the opening of U.S. equity markets today, in connection with the 2026 Russell U.S. Indexes Reconstitution. The Russell 3000® Index measures the performance o.

GuruFocus·Jun 29, 2026
Spruce Biosciences Joins the Russell 3000® Index

Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological diso

Business Wire·Jun 22, 2026
Spruce Biosciences Appoints Agnieszka Jurecka, M.D., Ph.D., MPH, as Vice President, Medical Affairs

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the appointment of Agnieszka “AJ” Jurecka, M.D., Ph.D., MPH, as Vice President, Medical Affairs. “We are delighted to welcome AJ to the Spruce executive team. She is a rare combination of practicing physician, scientist, and biopharmac.

Peers Comparison

Key metrics vs top competitors for Spruce Biosciences, Inc. (SPRB)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
SPRB logoSPRBSpruce Biosciences, Inc.Current
$51.85$71.14M-1.02-100%—-109.24%—
CORT logoCORTCorcept Therapeutics Incorporated
$91.61$9.83B111.7212.79%6.23%7.5%—
XNCR logoXNCRXencor, Inc.
$14.89$1.09B-12.0113.65%-185.71%-28.77%—
NTLA logoNTLAIntellia Therapeutics, Inc.
$17.84$2B-4.6816.92%-597.04%-57.27%—
RARE logoRAREUltragenyx Pharmaceutical Inc.
$33.70$3.31B-5.7820.13%-91.03%——
ACRS logoACRSAclaris Therapeutics, Inc.
$5.49$662.07M-10.36-58.19%-832.58%-55.89%—

Compare SPRB vs Peers

Spruce Biosciences, Inc. (SPRB) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs CORT

Most directly comparable listed peer for SPRB.

Scale Benchmark

vs IQV

Larger-name benchmark to compare SPRB against a more recognizable public peer.

Peer Set

Compare Top 5

vs CORT, XNCR, NTLA, RARE

SPRB SEC Filings & Documents

Spruce Biosciences, Inc. (SPRB) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 13, 2026·SEC

Material company update

Apr 22, 2026·SEC

Material company update

Mar 20, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 9, 2026·SEC

FY 2025

Apr 15, 2025·SEC

FY 2024

Mar 18, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 13, 2026·SEC

FY 2025

Nov 10, 2025·SEC

FY 2025

Aug 14, 2025·SEC

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SPRB Frequently Asked Questions

Spruce Biosciences, Inc. (SPRB) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
How fast is Spruce Biosciences, Inc. growing?

Spruce Biosciences, Inc. (SPRB) saw revenue decline by 100.0% over the past year.

Is SPRB profitable?

Spruce Biosciences, Inc. (SPRB) reported a net loss of $37.2M for fiscal year 2025.

Dividend & Returns
What is SPRB's return on equity?

Spruce Biosciences, Inc. (SPRB) has a return on equity (ROE) of -109.2%. Negative ROE indicates the company is unprofitable.

What is Spruce Biosciences, Inc.'s free cash flow?

Spruce Biosciences, Inc. (SPRB) had negative free cash flow of $29.3M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in SPRB back in 2018?

Total return calculator · dividends reinvested · 8+ years of data

See returns →