Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in SERA held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 5.5M | $11.2M | 0.0% | 14.397% | 0.06% |
| 2 | Whetstone Capital Advisors, LLC | 3.3M | $6.7M | -4.4% | 8.659% | 2.33% |
| 3 | abrdn plc | 2.6M | $5.2M | +11.9% | 6.679% | 0.01% |
| 4 | PSP Research LLC | 2.4M | $4.9M | — | 6.276% | 3.44% |
| 5 | Vivo Capital, LLC | 1.7M | $3.4M | 0.0% | 4.322% | 0.28% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 1.2M | $2.4M | — | 3.153% | 0.00% |
| 7 | CAPTRUST FINANCIAL ADVISORS | 537K | $1.1M | 0.0% | 1.405% | 0.00% |
| 8 | GEODE CAPITAL MANAGEMENT, LLC | 364K | $739K | +8.7% | 0.952% | 0.00% |
| 9 | SANDERS MORRIS HARRIS LLC | 315K | $639K | — | 0.825% | 0.10% |
| 10 | CITADEL ADVISORS LLC | 264K | $535K | -62.7% | 0.691% | 0.00% |
| 11 | AWM Investment Company, Inc. | 207K | $421K | 0.0% | 0.543% | 0.05% |
| 12 | BlackRock, Inc. | 196K | $398K | +5.0% | 0.513% | 0.00% |
| 13 | VANGUARD FIDUCIARY TRUST CO | 170K | $344K | — | 0.444% | 0.00% |
| 14 | STATE STREET CORP | 125K | $253K | 0.0% | 0.327% | 0.00% |
| 15 | MORGAN STANLEY | 105K | $213K | +29.7% | 0.275% | 0.00% |
| 16 | NORTHERN TRUST CORP | 97K | $196K | 0.0% | 0.253% | 0.00% |
| 17 | SEGALL BRYANT & HAMILL, LLC | 100K | $193K | — | 0.262% | 0.00% |
| 18 | MILLENNIUM MANAGEMENT LLC | 92K | $186K | -19.1% | 0.240% | 0.00% |
| 19 | Perigon Wealth Management, LLC | 73K | $148K | 0.0% | 0.190% | 0.00% |
| 20 | Bank of New York Mellon Corp | 61K | $124K | -19.1% | 0.160% | 0.00% |
| 21 | Requisite Capital Management, LLC | 56K | $113K | 0.0% | 0.146% | 0.02% |
| 22 | JANE STREET GROUP, LLC | 54K | $109K | -21.7% | 0.141% | 0.00% |
| 23 | Ballentine Partners, LLC | 50K | $101K | 0.0% | 0.130% | 0.00% |
| 24 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 46K | $93K | 0.0% | 0.120% | 0.00% |
| 25 | Twelve Points Wealth Management LLC | 43K | $88K | 0.0% | 0.114% | 0.02% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in SERA — a direct measure of their conviction.
Filings activity in SERA during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 56 | 1.8% | 56.71% | 15.75 pp | $40M | 22% |
| Q4 2025 | 57 | 8.1% | 72.46% | 5.06 pp | $52M | 6.5% |
| Q3 2025 | 62 | +3.3% | 77.52% | +5.72 pp | $55M | +8.0% |
| Q2 2025 | 60 | 15% | 71.80% | 28.78 pp | $51M | 29% |
| Q1 2025 | 71 | 4.1% | 100.58% | 99.41 pp | $72M | 51% |
| Q4 2024 | 74 | +21% | 199.99% | +3.45 pp | $145M | +3.5% |
| Q3 2024 | 61 | 4.7% | 196.54% | +61.51 pp | $140M | +46% |
| Q2 2024 | 64 | — | 135.03% | — | $96M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying SERA stock.
Based on Q1 2026 13F filings, institutional ownership of Sera Prognostics, Inc. stands at 56.7%, held across 56 reporting institutions.
BAKER BROS. ADVISORS LP is the largest reported institutional holder of SERA, with approximately 5,498,170 shares worth $0.01B as of Q1 2026.
Yes — 3 widely-followed marquee investors appear among the top 25 institutional holders of SERA, including CITADEL ADVISORS LLC, MILLENNIUM MANAGEMENT LLC, JANE STREET GROUP, LLC.
Our composite Smart Money Score for SERA is 46 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
12 institutions opened new positions in SERA during Q1 2026, while 13 fully exited. 1 added to existing positions and 42 trimmed.
SERA institutional ownership fell by 15.75 percentage points quarter-over-quarter, with a net change of -1 holders.
The top 10 institutions account for 90.7% of all reported 13F value in SERA, and the top 25 account for 98.0%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Sera Prognostics, Inc. (SERA) Institutional Ownership