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SERASera Prognostics, Inc.
$2.01$77M
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Sera Prognostics, Inc. (SERA) Financial Ratios

Latest Ratios: P/E Ratio -3.0x · EV/EBITDA N/A · ROE -51.8%. (2019–2025 historical series)

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly

SERA Valuation Multiples

Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Market Cap$77M$141M$270M$187M$39M$211M——
Enterprise Value$75M$139M$267M$185M$12M$153M——
P/E Ratio →-3.00———————
P/S Ratio947.701735.843505.16609.74145.482578.27——
P/B Ratio1.271.865.652.660.391.53——
P/FCF————————
P/OCF————————

P/E links to full P/E history page with 30-year chart

SERA EV Ratios

Enterprise-value multiples — capital-structure-neutral measures of total business value

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
EV / Revenue—1716.033463.56603.1344.561861.15——
EV / EBITDA————————
EV / EBIT————————
EV / FCF————————

SERA Profitability

Margins and return-on-capital ratios measuring operating efficiency

Margins

Full margin charts and quarterly trend are on the Earnings History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Gross Margin-102.5%-102.5%-6.5%31.4%28.0%54.9%56.0%50.0%
Operating Margin-45066.7%-45066.7%-47577.9%-13013.4%-17034.3%-43164.6%-71884.0%-46044.4%
Net Profit Margin-39417.3%-39417.3%-42724.7%-11843.8%-16487.3%-42693.9%-79392.0%-45891.7%

Return on Capital

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
ROE-51.8%-51.8%-55.8%-42.9%-37.2%-49.5%-285.7%-150.8%
ROA-36.6%-36.6%-39.2%-34.2%-33.6%-43.3%-104.3%-71.0%
ROIC-46.2%-46.2%-48.7%-42.7%-45.2%-68.3%——
ROCE-58.2%-58.2%-61.7%-46.4%-38.1%-49.8%-171.9%-95.5%

SERA Leverage & Debt

Solvency and debt-coverage ratios — lower is generally safer

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Debt / Equity0.030.030.020.030.030.002.920.85
Debt / EBITDA————————
Net Debt / Equity—-0.02-0.07-0.03-0.27-0.42-1.69-1.10
Net Debt / EBITDA————————
Debt / FCF————————
Interest Coverage-4056.00-4056.00-1173.93-657.95-723.36-45.93-9.79-7.38

Net cash position: cash ($4M) exceeds total debt ($2M)

SERA Liquidity & Efficiency

Short-term solvency ratios and asset-utilisation metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Current Ratio1.691.691.922.515.8013.111.223.65
Quick Ratio1.691.691.922.515.8013.111.223.65
Cash Ratio1.621.621.872.015.3212.501.203.62
Asset Turnover—0.000.000.000.000.000.000.00
Inventory Turnover————————
Days Sales Outstanding—54.07161.1713681.548325.5413990.1829.2010.14

SERA Shareholder Yields

Earnings, FCF, buyback, and dividend yields — total returns to shareholders

Dividends

Full dividend history and growth charts are on the Dividend History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Dividend Yield————————
Payout Ratio————————

Total Shareholder Return Metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Earnings Yield————————
FCF Yield————————
Buyback Yield0.0%0.0%0.0%0.0%0.0%0.0%——
Total Shareholder Yield0.0%0.0%0.0%0.0%0.0%0.0%——
Shares Outstanding—$48M$33M$31M$31M$31M$18M$18M

Key Metrics

Growth RegimeContracting
ProfitabilityNegative
Balance SheetVulnerable
Cash FlowBurning
Top Statement Risk

Imminent liquidity and solvency

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2026Q1)

Distressed Valuation Reflects Operational Stagnation

Based on reported figures, Sera's P/S ratio of 834.54 appears detached from commercial reality, suggesting that the market is pricing the company as a speculative R&D option rather than a functioning diagnostic enterprise with a clear path to sustainable revenue growth or profitability.

The extreme P/S multiple indicates that investors are not valuing the company based on current sales, which remain negligible at $81,000 TTM. This valuation level implies that the market is assigning value almost exclusively to the intellectual property and clinical data, rather than the underlying business model's ability to generate cash flow.

Capital Compounding Remains Fundamentally Negative

As reported in financial statements, Sera's ROIC has consistently remained in negative territory, reaching -10.0% in 2026Q1, which indicates that the company is currently destroying shareholder capital rather than compounding it through its ongoing clinical validation and market development efforts.

The persistent negative ROIC reflects a structural inability to generate returns that exceed the cost of capital, driven by high fixed costs and a lack of commercial scale. Without a significant shift in reimbursement or test volume, the company appears trapped in a cycle of capital consumption that erodes long-term value.

Working Capital Cycles Indicate Inefficiency

According to recent SEC filings, Sera's DSO has fluctuated significantly, reaching 74 days in 2026Q1, which suggests that the company faces substantial challenges in converting its diagnostic services into timely cash inflows from the fragmented US healthcare payer landscape.

The volatility in DSO and the lack of meaningful asset turnover highlight the difficulty of managing a high-fixed-cost laboratory model without the benefit of high-volume, predictable reimbursement. This inefficiency in the cash conversion cycle further exacerbates the company's reliance on external financing to sustain its daily operations.

Liquidity Position Signals Imminent Risk

Based on the most recent quarterly data, the company's cash position has dwindled to $3.9 million, which, when viewed against historical quarterly burn rates, suggests an extremely limited runway that warrants immediate investor concern regarding the firm's ability to continue as a going concern.

While the current ratio of 2.12 might appear superficially healthy, it is heavily distorted by the lack of meaningful revenue and the high proportion of current liabilities relative to cash. Investors should monitor the company's ability to secure additional funding, as the current liquidity profile appears insufficient to support long-term operations.

Misapplication of Revenue-Based Valuation Metrics

The most commonly misapplied ratio for Sera is the Price-to-Sales multiple, which obscures the company's status as a pre-commercial R&D entity by suggesting a growth trajectory that is not supported by the current $81,000 TTM revenue figure or the lack of insurance coverage.

Analysts should instead focus on 'Payer Lives Under Contract' and 'Cash Runway' as primary indicators of viability, as these metrics better capture the company's progress toward a sustainable commercial model. Relying on traditional valuation multiples for a company in this stage of development may lead to a significant misinterpretation of its intrinsic value.

Download Financial Ratios Data

Includes 30+ ratios · 7 years · Updated daily

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SERA — Frequently Asked Questions

Quick answers to the most common questions about buying SERA stock.

What is Sera Prognostics, Inc.'s P/E ratio?

Sera Prognostics, Inc.'s current P/E ratio is -3.0x. This places it at the 50th percentile of its historical range.

What is Sera Prognostics, Inc.'s ROE?

Sera Prognostics, Inc.'s return on equity (ROE) is -51.8%. The historical average is -96.2%.

Is SERA stock overvalued?

Based on historical data, Sera Prognostics, Inc. is trading at a P/E of -3.0x. This is at the 50th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.

What are Sera Prognostics, Inc.'s profit margins?

Sera Prognostics, Inc. has -102.5% gross margin and -45066.7% operating margin.