Latest Ratios: P/E Ratio -3.0x · EV/EBITDA N/A · ROE -51.8%. (2019–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Market Cap | $77M | $141M | $270M | $187M | $39M | $211M | — | — |
| Enterprise Value | $75M | $139M | $267M | $185M | $12M | $153M | — | — |
| P/E Ratio → | -3.00 | — | — | — | — | — | — | — |
| P/S Ratio | 947.70 | 1735.84 | 3505.16 | 609.74 | 145.48 | 2578.27 | — | — |
| P/B Ratio | 1.27 | 1.86 | 5.65 | 2.66 | 0.39 | 1.53 | — | — |
| P/FCF | — | — | — | — | — | — | — | — |
| P/OCF | — | — | — | — | — | — | — | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 1716.03 | 3463.56 | 603.13 | 44.56 | 1861.15 | — | — |
| EV / EBITDA | — | — | — | — | — | — | — | — |
| EV / EBIT | — | — | — | — | — | — | — | — |
| EV / FCF | — | — | — | — | — | — | — | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Gross Margin | -102.5% | -102.5% | -6.5% | 31.4% | 28.0% | 54.9% | 56.0% | 50.0% |
| Operating Margin | -45066.7% | -45066.7% | -47577.9% | -13013.4% | -17034.3% | -43164.6% | -71884.0% | -46044.4% |
| Net Profit Margin | -39417.3% | -39417.3% | -42724.7% | -11843.8% | -16487.3% | -42693.9% | -79392.0% | -45891.7% |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| ROE | -51.8% | -51.8% | -55.8% | -42.9% | -37.2% | -49.5% | -285.7% | -150.8% |
| ROA | -36.6% | -36.6% | -39.2% | -34.2% | -33.6% | -43.3% | -104.3% | -71.0% |
| ROIC | -46.2% | -46.2% | -48.7% | -42.7% | -45.2% | -68.3% | — | — |
| ROCE | -58.2% | -58.2% | -61.7% | -46.4% | -38.1% | -49.8% | -171.9% | -95.5% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.03 | 0.03 | 0.02 | 0.03 | 0.03 | 0.00 | 2.92 | 0.85 |
| Debt / EBITDA | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | -0.02 | -0.07 | -0.03 | -0.27 | -0.42 | -1.69 | -1.10 |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — |
| Debt / FCF | — | — | — | — | — | — | — | — |
| Interest Coverage | -4056.00 | -4056.00 | -1173.93 | -657.95 | -723.36 | -45.93 | -9.79 | -7.38 |
Net cash position: cash ($4M) exceeds total debt ($2M)
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Current Ratio | 1.69 | 1.69 | 1.92 | 2.51 | 5.80 | 13.11 | 1.22 | 3.65 |
| Quick Ratio | 1.69 | 1.69 | 1.92 | 2.51 | 5.80 | 13.11 | 1.22 | 3.65 |
| Cash Ratio | 1.62 | 1.62 | 1.87 | 2.01 | 5.32 | 12.50 | 1.20 | 3.62 |
| Asset Turnover | — | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Inventory Turnover | — | — | — | — | — | — | — | — |
| Days Sales Outstanding | — | 54.07 | 161.17 | 13681.54 | 8325.54 | 13990.18 | 29.20 | 10.14 |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | — | — | — | — | — |
| FCF Yield | — | — | — | — | — | — | — | — |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — | — |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — | — |
| Shares Outstanding | — | $48M | $33M | $31M | $31M | $31M | $18M | $18M |
Imminent liquidity and solvency
Based on reported figures, Sera's P/S ratio of 834.54 appears detached from commercial reality, suggesting that the market is pricing the company as a speculative R&D option rather than a functioning diagnostic enterprise with a clear path to sustainable revenue growth or profitability.
The extreme P/S multiple indicates that investors are not valuing the company based on current sales, which remain negligible at $81,000 TTM. This valuation level implies that the market is assigning value almost exclusively to the intellectual property and clinical data, rather than the underlying business model's ability to generate cash flow.
As reported in financial statements, Sera's ROIC has consistently remained in negative territory, reaching -10.0% in 2026Q1, which indicates that the company is currently destroying shareholder capital rather than compounding it through its ongoing clinical validation and market development efforts.
The persistent negative ROIC reflects a structural inability to generate returns that exceed the cost of capital, driven by high fixed costs and a lack of commercial scale. Without a significant shift in reimbursement or test volume, the company appears trapped in a cycle of capital consumption that erodes long-term value.
According to recent SEC filings, Sera's DSO has fluctuated significantly, reaching 74 days in 2026Q1, which suggests that the company faces substantial challenges in converting its diagnostic services into timely cash inflows from the fragmented US healthcare payer landscape.
The volatility in DSO and the lack of meaningful asset turnover highlight the difficulty of managing a high-fixed-cost laboratory model without the benefit of high-volume, predictable reimbursement. This inefficiency in the cash conversion cycle further exacerbates the company's reliance on external financing to sustain its daily operations.
Based on the most recent quarterly data, the company's cash position has dwindled to $3.9 million, which, when viewed against historical quarterly burn rates, suggests an extremely limited runway that warrants immediate investor concern regarding the firm's ability to continue as a going concern.
While the current ratio of 2.12 might appear superficially healthy, it is heavily distorted by the lack of meaningful revenue and the high proportion of current liabilities relative to cash. Investors should monitor the company's ability to secure additional funding, as the current liquidity profile appears insufficient to support long-term operations.
The most commonly misapplied ratio for Sera is the Price-to-Sales multiple, which obscures the company's status as a pre-commercial R&D entity by suggesting a growth trajectory that is not supported by the current $81,000 TTM revenue figure or the lack of insurance coverage.
Analysts should instead focus on 'Payer Lives Under Contract' and 'Cash Runway' as primary indicators of viability, as these metrics better capture the company's progress toward a sustainable commercial model. Relying on traditional valuation multiples for a company in this stage of development may lead to a significant misinterpretation of its intrinsic value.
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Quick answers to the most common questions about buying SERA stock.
Sera Prognostics, Inc.'s current P/E ratio is -3.0x. This places it at the 50th percentile of its historical range.
Sera Prognostics, Inc.'s return on equity (ROE) is -51.8%. The historical average is -96.2%.
Based on historical data, Sera Prognostics, Inc. is trading at a P/E of -3.0x. This is at the 50th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.
Sera Prognostics, Inc. has -102.5% gross margin and -45066.7% operating margin.