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RYTMRhythm Pharmaceuticals, Inc.
$114.46$7.8B
Overview & Verdict
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RYTM logoRhythm Pharmaceuticals, Inc.(RYTM)Earnings, Financials & Key Ratios

RYTM•NASDAQ
$114.46
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryMetabolic and Obesity Therapies
AboutRhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the development and commercialization of therapeutics for the treatment of rare genetic diseases of obesity. The company's lead product candidate is IMCIVREE, a potent melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, and Bardet-Biedl and Alström syndrome. It is also developing setmelanotide, which is in Phase II clinical trials for treating POMC or LEPR heterozygous deficiency obesities, steroid receptor coactivator 1 deficiency obesity, SH2B1 deficiency obesity, MC4 receptor deficiency obesity, Smith-Magenis syndrome obesity, POMC epigenetic disorders, and other MC4R disorders. Rhythm Pharmaceuticals, Inc. has a collaborative research agreement with the Clinical Registry Investigating Bardet-Biedl Syndrome. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.Show more
  • Revenue$190M+45.8%
  • EBITDA-$191M+27.8%
  • Net Income-$197M+24.6%
  • EPS (Diluted)-3.11+28.3%
  • Gross Margin89.73%
  • EBITDA Margin-100.49%+50.5%
  • Operating Margin-101.19%+50.4%
  • Net Margin-103.57%+48.3%
  • ROE-129.46%+17.0%

RYTM Price & Volume

Rhythm Pharmaceuticals, Inc. (RYTM) stock price & volume — 10-year historical chart

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Orphan Drug Growth Faces Severe Liquidity Constraints

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Expanding
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Liquidity and financing risk

Key Thesis Takeaways

  • Rhythm Pharmaceuticals is successfully scaling IMCIVREE revenue, evidenced by a 45.83% year-over-year growth rate, yet the company remains trapped in a cycle of heavy R&D and SG&A spending that prevents operational profitability.
  • The rapid accumulation of debt, which surged to $246.5 million by 2025Q4, combined with a dwindling cash balance of $54.3 million, creates a precarious financial profile.
  • Investors should monitor whether the company can achieve a self-sustaining capital structure before the current liquidity runway necessitates further dilutive financing.

Verdict Logic

the company's precarious liquidity position, highlighted by a $54.3 million cash balance against a TTM net loss exceeding $190 million, suggests that significant financing risks remain for shareholders.

RYTM Growth Metrics

Rhythm Pharmaceuticals, Inc. (RYTM) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years100.23%
TTM58.67%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-20.8%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-13%

Return on Capital

10 Years-67.45%
5 Years-69.17%
3 Years-71.38%
Last Year-58.9%

RYTM Recent Earnings

Rhythm Pharmaceuticals, Inc. (RYTM) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 4/12 qtrs (33%)●Beat Revenue 4/12 qtrs (33%)
Q2 2026Latest
May 5, 2026
Metric
Actual
Est
EPS
$0.83+3.5%
$0.86
Rev
$60M+7.8%
$56M
Q1 2026
Feb 26, 2026
Metric
Actual
Est
EPS
$0.73+7.6%
$0.79
Rev
$57M+1.9%
$56M
Q4 2025
Nov 4, 2025
Metric
Actual
Est
EPS
$0.82-13.9%
$0.72
Rev
$51M-8.4%
$56M
Q3 2025
Aug 5, 2025
Metric
Actual
Est
EPS
$0.75-13.6%
$0.66
Rev
$49M-5.5%
$51M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 5, 2026
$0.83vs $0.86+3.5%
$60Mvs $56M+7.8%
Q1 2026Feb 26, 2026
$0.73vs $0.79+7.6%
$57Mvs $56M+1.9%
Q4 2025Nov 4, 2025
$0.82vs $0.72-13.9%
$51Mvs $56M-8.4%
Q3 2025Aug 5, 2025
$0.75vs $0.66-13.6%
$49Mvs $51M-5.5%
Based on last 12 quarters of dataView full earnings history →

Latest RYTM News

Recent stock market news and headlines for Rhythm Pharmaceuticals, Inc. (RYTM)

Seeking Alpha·Jun 17, 2026
Rhythm Pharmaceuticals, Inc. (RYTM) Discusses Positive Interim Results from Phase 2 Setmelanotide Trial in Prader-Willi Syndrome Transcript

Rhythm Pharmaceuticals, Inc. (RYTM) Discusses Positive Interim Results from Phase 2 Setmelanotide Trial in Prader-Willi Syndrome Transcript

Proactive Investors·Jun 16, 2026
Rhythm Pharmaceuticals posts long-term setmelanotide data for obesity

Rhythm Pharmaceuticals, Inc. (NASDAQ: RGPX) reported that setmelanotide therapy produced robust, sustained and clinically significant weight loss in patients with acquired hypothalamic obesity at 2.5 years. Alongside the long-term setmelanotide results, Rhythm reported that bivamelagon therapy achieved progressive reductions in body mass index and hunger measures in patients with acquired hypothalamic obesity at one year.

GlobeNewsWire·Jun 15, 2026
Rhythm Pharmaceuticals Announces Multiple New Data Presentations from MC4R Agonists in Acquired Hypothalamic Obesity (HO), Bardet-Biedl Syndrome (BBS) and Prader-Willi Syndrome (PWS) at ENDO 2026

BOSTON, June 15, 2026 (GLOBE NEWSWIRE) -- Rhythm Pharmaceuticals, Inc. (Nasdaq: RYTM), a global commercial-stage biopharmaceutical company focused on transforming the lives of patients living with rare neuroendocrine diseases, today announced new data from multiple presentations during the Endocrine Society's Annual Meeting (ENDO 2026) in Chicago.

Benzinga·Jun 15, 2026
Why Is Rhythm Pharma Stock Jumping Today?

Rhythm Pharmaceuticals Inc. (NASDAQ:RYTM) stock is trading higher on Monday after the company reported preliminary results from an ongoing Phase 2 study evaluating setmelanotide in patients with Prader-Willi syndrome (PWS).

Peers Comparison

Key metrics vs top competitors for Rhythm Pharmaceuticals, Inc. (RYTM)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
RYTM logoRYTMRhythm Pharmaceuticals, Inc.Current
$114.46$7.84B-36.8045.83%-103.57%-129.46%—
HALO logoHALOHalozyme Therapeutics, Inc.
$81.57$9.68B31.8637.55%23.13%126.27%—
RARE logoRAREUltragenyx Pharmaceutical Inc.
$35.87$3.53B-6.1520.13%-91.03%——
FOLD logoFOLDAmicus Therapeutics, Inc.
$14.49$4.55B-164.8520.05%-4.27%-12.02%—
ACMR logoACMRACM Research, Inc.
$94.66$6.27B69.0915.24%9.48%5.13%—
PTCT logoPTCTPTC Therapeutics, Inc.
$89.20$7.4B11.47114.51%-22.58%——

Compare RYTM vs Peers

Rhythm Pharmaceuticals, Inc. (RYTM) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs HALO

Most directly comparable listed peer for RYTM.

Scale Benchmark

vs LLY

Larger-name benchmark to compare RYTM against a more recognizable public peer.

Peer Set

Compare Top 5

vs HALO, RARE, FOLD, ACMR

RYTM SEC Filings & Documents

Rhythm Pharmaceuticals, Inc. (RYTM) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 5, 2026·SEC

Material company update

Apr 3, 2026·SEC

Material company update

Mar 26, 2026·SEC

10-K Annual Reports

2
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 28, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

May 5, 2026·SEC

FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 5, 2025·SEC

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RYTM Frequently Asked Questions

Rhythm Pharmaceuticals, Inc. (RYTM) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Rhythm Pharmaceuticals, Inc.'s revenue?

Rhythm Pharmaceuticals, Inc. (RYTM) reported $217.2M in revenue for fiscal year 2025.

How fast is Rhythm Pharmaceuticals, Inc. growing?

Rhythm Pharmaceuticals, Inc. (RYTM) grew revenue by 45.8% over the past year. This is strong growth.

Is RYTM profitable?

Rhythm Pharmaceuticals, Inc. (RYTM) reported a net loss of $203.8M for fiscal year 2025.

Dividend & Returns
What is RYTM's return on equity?

Rhythm Pharmaceuticals, Inc. (RYTM) has a return on equity (ROE) of -129.5%. Negative ROE indicates the company is unprofitable.

What is Rhythm Pharmaceuticals, Inc.'s free cash flow?

Rhythm Pharmaceuticals, Inc. (RYTM) had negative free cash flow of $76.3M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in RYTM back in 2012?

Total return calculator · dividends reinvested · 14+ years of data

See returns →