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EXELExelixis, Inc.
$57.08$14.5B
Overview & Verdict
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EXEL logoExelixis, Inc.(EXEL)Earnings, Financials & Key Ratios

EXEL•NASDAQ
$57.08
20.5× P/E·Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutExelixis, Inc., an oncology-focused biotechnology company, focuses on the discovery, development, and commercialization of new medicines to treat cancers in the United States. The company's products include CABOMETYX tablets for the treatment of patients with advanced renal cell carcinoma who received prior anti-angiogenic therapy; and COMETRIQ capsules for the treatment of patients with progressive and metastatic medullary thyroid cancer. Its CABOMETYX and COMETRIQ are derived from cabozantinib, an inhibitor of multiple tyrosine kinases, including MET, AXL, RET, and VEGF receptors. The company also offers COTELLIC, an inhibitor of MEK as a combination regimen to treat advanced melanoma; and MINNEBRO, an oral non-steroidal selective blocker of the mineralocorticoid receptor for the treatment of hypertension in Japan. In addition, it is developing XL092, an oral tyrosine kinase inhibitor that targets VEGF receptors, MET, AXL, MER, and other kinases implicated in growth and spread of cancer; XB002, an antibody-drug conjugate composed of human mAb against tissue factor (TF) for the treatment of advanced solid tumors; XL102, an orally bioavailable cyclin-dependent kinase 7 (CDK7) inhibitor for the treatment of advanced or metastatic solid tumors; and XB002 for the treatment of non-hodgkin's lymphoma. Exelixis, Inc. has research collaborations and license agreements with Ipsen Pharma SAS; Takeda Pharmaceutical Company Ltd.; F. Hoffmann-La Roche Ltd.; Redwood Bioscience, Inc.; R.P. Scherer Technologies, LLC; Catalent Pharma Solutions, Inc.; NBE Therapeutics AG; Aurigene Discovery Technologies Limited; Iconic Therapeutics, Inc.; Invenra, Inc.; StemSynergy Therapeutics, Inc.; Genentech, Inc.; Bristol-Myers Squibb Company; and Daiichi Sankyo Company, Limited. The company was formerly known as Exelixis Pharmaceuticals, Inc. and changed its name to Exelixis, Inc. in February 2000. Exelixis, Inc. was incorporated in 1994 and is headquartered in Alameda, California.Show more
  • Revenue$2.32B+7.0%
  • EBITDA$901M+42.3%
  • Net Income$783M+50.1%
  • EPS (Diluted)2.78+58.0%
  • Gross Margin96.39%
  • EBITDA Margin38.84%+33.0%
  • Operating Margin37.59%+34.8%
  • Net Margin33.73%+40.3%
  • ROE35.53%+53.6%

EXEL Price & Volume

Exelixis, Inc. (EXEL) stock price & volume — 10-year historical chart

Loading chart...

Oncology Portfolio Strength Faces Litigation Revenue Risks

Investment Thesis • Updated 2026Q1

VerdictNeutral
Growth:Mixed
Profitability:Strong
Financial:Healthy
Cash Flow:Mixed
Primary Risk:Generic entry litigation exposure

Key Thesis Takeaways

  • Exelixis demonstrates robust profitability with gross margins consistently exceeding 95%, yet its long-term terminal value remains tethered to the outcome of Hatch-Waxman litigation regarding its core cabozantinib franchise.
  • While the company maintains a conservative capital structure with a 0.09 debt-to-equity ratio, the reliance on lumpy milestone payments and aggressive share repurchases—evidenced by a $430.4 million outflow in 2026Q1—creates significant cash flow volatility.
  • Investors should monitor the sustainability of operating margins, which expanded to 41.1% in 2026Q1, against the potential for accelerated revenue erosion from generic competition.

Verdict Logic

while the company maintains a healthy balance sheet and a 15.55 forward P/E ratio, the material risk of generic litigation and volatile cash flow generation warrants a cautious approach.

EXEL Growth Metrics

Exelixis, Inc. (EXEL) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years51.19%
5 Years18.63%
3 Years12.93%
TTM3.33%

Profit CAGR

10 Years-
5 Years47.58%
3 Years62.53%
TTM29.5%

EPS CAGR

10 Years-
5 Years51.35%
3 Years70.59%
TTM37.9%

Return on Capital

10 Years19.33%
5 Years17.37%
3 Years21.74%
Last Year35.01%

EXEL Recent Earnings

Exelixis, Inc. (EXEL) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 10/12 qtrs (83%)●Beat Revenue 8/12 qtrs (67%)
Q2 2026Latest
May 5, 2026
Metric
Actual
Est
EPS
$0.87+13.7%
$0.77
Rev
$611M+0.5%
$608M
Q1 2026
Feb 10, 2026
Metric
Actual
Est
EPS
$0.94+22.1%
$0.77
Rev
$599M+0.4%
$597M
Q4 2025
Nov 4, 2025
Metric
Actual
Est
EPS
$0.78+13.9%
$0.69
Rev
$598M+1.3%
$590M
Q3 2025
Jul 28, 2025
Metric
Actual
Est
EPS
$0.75+15.4%
$0.65
Rev
$568M-4.5%
$595M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 5, 2026
$0.87vs $0.77+13.7%
$611Mvs $608M+0.5%
Q1 2026Feb 10, 2026
$0.94vs $0.77+22.1%
$599Mvs $597M+0.4%
Q4 2025Nov 4, 2025
$0.78vs $0.69+13.9%
$598Mvs $590M+1.3%
Q3 2025Jul 28, 2025
$0.75vs $0.65+15.4%
$568Mvs $595M-4.5%
Based on last 12 quarters of dataView full earnings history →

Latest EXEL News

Recent stock market news and headlines for Exelixis, Inc. (EXEL)

Zacks Investment Research·1 day ago
Why Exelixis (EXEL) is a Top Value Stock for the Long-Term

Whether you're a value, growth, or momentum investor, finding strong stocks becomes easier with the Zacks Style Scores, a top feature of the Zacks Premium research service.

Zacks Investment Research·Jun 23, 2026
EXEL Down on Colorectal Cancer Study Data on Zanzalintinib

Exelixis falls after STELLAR-303 misses statistical significance in overall survival for a key colorectal cancer subgroup, raising approval uncertainty.

Zacks Investment Research·Jun 23, 2026
Here's Why Exelixis (EXEL) is a Strong Growth Stock

The Zacks Style Scores offers investors a way to easily find top-rated stocks based on their investing style. Here's why you should take advantage.

Business Wire·Jun 22, 2026
Exelixis Provides Update on the Phase 3 STELLAR-303 Trial Evaluating Zanzalintinib in Combination with an Immune Checkpoint Inhibitor in Patients with Metastatic Colorectal Cancer

ALAMEDA, Calif.--(BUSINESS WIRE)--Exelixis, Inc. (Nasdaq: EXEL) today announced results from the final analysis of the dual primary endpoint of overall survival (OS) in the subset of patients without active liver metastases (non-liver metastases, NLM) in the phase 3 STELLAR-303 pivotal trial evaluating zanzalintinib in combination with atezolizumab (Tecentriq®) versus regorafenib in previously treated non-microsatellite instability (MSI)-high metastatic colorectal cancer (mCRC).

Zacks Investment Research·Jun 19, 2026
Here's Why Exelixis (EXEL) is a Strong Value Stock

The Zacks Style Scores offers investors a way to easily find top-rated stocks based on their investing style. Here's why you should take advantage.

Peers Comparison

Key metrics vs top competitors for Exelixis, Inc. (EXEL)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
EXEL logoEXELExelixis, Inc.Current
$57.08$14.5B20.536.98%33.73%35.53%—
INCY logoINCYIncyte Corporation
$118.05$23.58B18.4221.22%26.71%29.31%—
ALKS logoALKSAlkermes plc
$55.22$9.2B38.62-5.25%9.78%8.82%—
JAZZ logoJAZZJazz Pharmaceuticals plc
$247.72$15.54B-42.424.88%0.66%0.71%—
IONS logoIONSIonis Pharmaceuticals, Inc.
$86.33$14.27B-36.2733.87%-30.87%-58.57%—
HALO logoHALOHalozyme Therapeutics, Inc.
$81.57$9.68B31.8637.55%23.13%126.27%—

Compare EXEL vs Peers

Exelixis, Inc. (EXEL) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs INCY

Most directly comparable listed peer for EXEL.

Scale Benchmark

vs MRK

Larger-name benchmark to compare EXEL against a more recognizable public peer.

Peer Set

Compare Top 5

vs INCY, ALKS, JAZZ, IONS

EXEL SEC Filings & Documents

Exelixis, Inc. (EXEL) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 5, 2026·SEC

Material company update

Feb 10, 2026·SEC

Material company update

Jan 12, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 10, 2026·SEC

FY 2025

Feb 11, 2025·SEC

FY 2024

Feb 6, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 5, 2026·SEC

FY 2025

Nov 4, 2025·SEC

FY 2025

Jul 28, 2025·SEC

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EXEL Frequently Asked Questions

Exelixis, Inc. (EXEL) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Exelixis, Inc.'s revenue?

Exelixis, Inc. (EXEL) reported $2.38B in revenue for fiscal year 2025. This represents a 22524% increase from $10.5M in 1999.

How fast is Exelixis, Inc. growing?

Exelixis, Inc. (EXEL) grew revenue by 7.0% over the past year. This is steady growth.

Is EXEL profitable?

Yes, Exelixis, Inc. (EXEL) is profitable, generating $833.4M in net income for fiscal year 2025 (33.7% net margin).

Dividend & Returns
What is EXEL's return on equity?

Exelixis, Inc. (EXEL) has a return on equity (ROE) of 35.5%. This is excellent, indicating efficient use of shareholder capital.

What is Exelixis, Inc.'s free cash flow?

Exelixis, Inc. (EXEL) generated $918.4M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

What if you invested $1,000 in EXEL back in 1999?

Total return calculator · dividends reinvested · 27+ years of data

See returns →