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CLLSCellectis S.A.
$3.22$323M
Overview & Verdict
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CLLS logoCellectis S.A.(CLLS)Earnings, Financials & Key Ratios

CLLS•NASDAQ
$3.22
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutCellectis S.A., a clinical stage biotechnological company, develops immuno-oncology products based on gene-edited T-cells that express chimeric antigen receptors to target and eradicate cancer cells. It operates through two segments, Therapeutics and Plants. The company is developing UCART19, an allogeneic T-cell product candidate for the treatment of CD19-expressing hematologic malignancies, such as acute lymphoblastic leukemia; ALLO-501 and ALLO-501A to treat relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma; ALLO-316 for the treatment of Renal Cell Carcinoma; UCART123 for the treatment of acute myeloid leukemia; and UCART22 to treat B-cell acute lymphoblastic leukemia. It is also developing UCARTCS1 and ALLO-715 for the treatment of multiple myeloma. The company has strategic alliances with Allogene Therapeutics, Inc.; Les Laboratoires Servier; The University of Texas M.D. Anderson Cancer Center; and Iovance Biotherapeutics, as well as a strategic research and development collaboration with Cytovia Therapeutics, Inc. Cellectis S.A. was founded in 1999 and is headquartered in Paris, France.Show more
  • Revenue$73M+75.8%
  • EBITDA-$13M+67.2%
  • Net Income-$68M-83.9%
  • EPS (Diluted)-0.68-65.9%
  • Gross Margin86.57%+11.2%
  • EBITDA Margin-17.84%+81.4%
  • Operating Margin-45.34%+68.4%
  • Net Margin-92.66%-4.6%
  • ROE-65.33%-91.7%

CLLS Price & Volume

Cellectis S.A. (CLLS) stock price & volume — 10-year historical chart

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Milestone Dependency Masks Persistent Clinical Cash Burn

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Clinical Milestone Funding Dependency

Key Thesis Takeaways

  • Cellectis remains a high-risk, clinical-stage biotechnology firm whose financial stability is tethered to volatile, non-recurring milestone payments rather than a sustainable commercial revenue model.
  • While the company maintains high gross margins, often exceeding 80%, these are consistently neutralized by inelastic R&D expenditures that average over $23 million per quarter.
  • Investors should remain cautious as the rapid erosion of the cash balance to $35.0 million in 2026Q1, coupled with a rising debt-to-equity ratio of 1.81, suggests an urgent need for further capital infusion to sustain operations.

Verdict Logic

the company's reliance on non-recurring milestones and the rapid depletion of its cash buffer to $35.0 million in 2026Q1 present significant insolvency risks for long-term investors.

CLLS Growth Metrics

Cellectis S.A. (CLLS) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years2.86%
5 Years7.4%
3 Years56.12%
TTM42.95%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-11.17%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-8.45%

Return on Capital

10 Years-28.26%
5 Years-31.94%
3 Years-32.77%
Last Year-16.69%

CLLS Recent Earnings

Cellectis S.A. (CLLS) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 6/12 qtrs (50%)●Beat Revenue 5/12 qtrs (42%)
Q2 2026Latest
May 11, 2026
Metric
Actual
Est
EPS
$0.18+30.3%
$0.26
Rev
$8M-31.6%
$11M
Q2 2026
Mar 19, 2026
Metric
Actual
Est
EPS
$0.26-27.9%
$0.20
Rev
$12M-8.9%
$13M
Q4 2025
Nov 7, 2025
Metric
Actual
Est
EPS
$0.01+110.0%
$0.10
Rev
$35M+242.4%
$10M
Q3 2025
Aug 4, 2025
Metric
Actual
Est
EPS
$0.24-140.0%
$0.10
Rev
$17M+106.0%
$8M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 11, 2026
$0.18vs $0.26+30.3%
$8Mvs $11M-31.6%
Q2 2026Mar 19, 2026
$0.26vs $0.20-27.9%
$12Mvs $13M-8.9%
Q4 2025Nov 7, 2025
$0.01vs $0.10+110.0%
$35Mvs $10M+242.4%
Q3 2025Aug 4, 2025
$0.24vs $0.10-140.0%
$17Mvs $8M+106.0%
Based on last 12 quarters of dataView full earnings history →

Latest CLLS News

Recent stock market news and headlines for Cellectis S.A. (CLLS)

GlobeNewsWire·Jun 25, 2026
Cellectis Reports Results from Shareholders Meeting Held on June 25, 2026

NEW YORK, June 25, 2026 (GLOBE NEWSWIRE) -- Cellectis (the “Company”) (Euronext Growth: ALCLS- NASDAQ: CLLS), a clinical-stage biotechnology company using its pioneering gene-editing platform to develop life-saving cell and gene therapies, held today its shareholders general meeting at 2:30 p.m. CET at the Biopark auditorium, 11 rue Watt, 4th floor, 75013 Paris, France.

Peers Comparison

Key metrics vs top competitors for Cellectis S.A. (CLLS)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
CLLS logoCLLSCellectis S.A.Current
$3.22$323.31M-4.7475.76%-92.66%-65.33%—
CRSP logoCRSPCRISPR Therapeutics AG
$60.77$5.86B-9.39-89.97%-13856.54%-30.88%—
BEAM logoBEAMBeam Therapeutics Inc.
$37.92$3.9B-46.81120.01%-49.17%-5.89%—
EDIT logoEDITEditas Medicine, Inc.
$3.75$367.15M-2.0825.39%-281.59%-677.39%—
NTLA logoNTLAIntellia Therapeutics, Inc.
$17.43$1.96B-4.5716.92%-597.04%-57.27%—
FATE logoFATEFate Therapeutics, Inc.
$3.02$352.01M-2.63-51.24%-2056.79%-58.89%—

Compare CLLS vs Peers

Cellectis S.A. (CLLS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs CRSP

Most directly comparable listed peer for CLLS.

Scale Benchmark

vs TMO

Larger-name benchmark to compare CLLS against a more recognizable public peer.

Peer Set

Compare Top 5

vs CRSP, BEAM, EDIT, NTLA

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CLLS Frequently Asked Questions

Cellectis S.A. (CLLS) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Cellectis S.A.'s revenue?

Cellectis S.A. (CLLS) reported $68.1M in revenue for fiscal year 2025. This represents a 1560% increase from $4.1M in 2007.

How fast is Cellectis S.A. growing?

Cellectis S.A. (CLLS) grew revenue by 75.8% over the past year. This is strong growth.

Is CLLS profitable?

Cellectis S.A. (CLLS) reported a net loss of $67.3M for fiscal year 2025.

Dividend & Returns
What is CLLS's return on equity?

Cellectis S.A. (CLLS) has a return on equity (ROE) of -65.3%. Negative ROE indicates the company is unprofitable.

What is Cellectis S.A.'s free cash flow?

Cellectis S.A. (CLLS) had negative free cash flow of $40.1M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in CLLS back in 2007?

Total return calculator · dividends reinvested · 19+ years of data

See returns →