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BCRXBioCryst Pharmaceuticals, Inc.
$10.99$2.3B
Overview & Verdict
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BCRX logoBioCryst Pharmaceuticals, Inc.(BCRX)Earnings, Financials & Key Ratios

BCRX•NASDAQ
$10.99
9.1× P/E·Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Rare Disease Biopharma
AboutBioCryst Pharmaceuticals, Inc., a biotechnology company, discovers novel, oral, and small-molecule medicines. The company markets peramivir injection, an intravenous neuraminidase inhibitor for the treatment of acute uncomplicated influenza under the RAPIVAB, RAPIACTA, and PERAMIFLU names; and ORLADEYO, an oral serine protease inhibitor to treat hereditary angioedema. It is also developing BCX9930, an oral factor D inhibitor, which is in Phase II clinical trial for complement-mediated diseases; BCX9250, an oral activin receptor-like kinase-2 inhibitor that is in Phase I clinical trial to treat fibrodysplasia ossificans progressiva; and Galidesivir, a RNA dependent-RNA polymerase inhibitor, which is in Phase I clinical trial to treat various RNA viruses, including Marburg, Yellow Fever, Ebola, and Zika. The company has collaborations and in-license relationships with the Torii Pharmaceutical Co., Ltd.; Seqirus UK Limited; Shionogi & Co., Ltd.; Green Cross Corporation; Mundipharma International Holdings Limited; National Institute of Allergy and Infectious Diseases; Biomedical Advanced Research and Development Authority; the U.S. Department of Health and Human Services; and The University of Alabama at Birmingham, as well as Albert Einstein College of Medicine of Yeshiva University and Industrial Research, Ltd. BioCryst Pharmaceuticals, Inc. was founded in 1986 and is headquartered in Durham, North Carolina.Show more
  • Revenue$875M+94.1%
  • EBITDA$342M+26497.7%
  • Net Income$264M+396.9%
  • EPS (Diluted)1.21+381.4%
  • Gross Margin97.82%+0.6%
  • EBITDA Margin39.14%+13698.4%
  • Operating Margin38.98%+7008.4%
  • Net Margin30.16%+252.9%

BCRX Price & Volume

BioCryst Pharmaceuticals, Inc. (BCRX) stock price & volume — 10-year historical chart

Loading chart...

Orladeyo Commercial Scaling Masks Structural Equity Deficit

Investment Thesis • Updated 2026Q1

VerdictNeutral
Growth:Mixed
Profitability:Moderate
Financial:Vulnerable
Cash Flow:Mixed
Primary Risk:Single-asset commercial dependency

Key Thesis Takeaways

  • BioCryst is currently navigating a critical transition phase where the commercial success of Orladeyo is driving significant operating margin expansion, reaching 64% in 2025Q4.
  • However, the company's long-term outlook remains clouded by a persistent negative equity position of $553.8 million as of 2026Q1 and a heavy reliance on a single-asset portfolio.
  • Investors should monitor whether the company can sustain its recent cash flow improvements or if future capital requirements will necessitate further dilutive financing to address its structural balance sheet challenges.

Verdict Logic

while the company demonstrated a 67.7% free cash flow margin in 2025Q4, the ongoing $553.8 million equity deficit and reliance on a single-asset revenue stream present substantial long-term execution risks.

BCRX Growth Metrics

BioCryst Pharmaceuticals, Inc. (BCRX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years33.61%
5 Years117.89%
3 Years47.82%
TTM75.92%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-756.52%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-585.12%

Return on Capital

10 Years-52.75%
5 Years-0.57%
3 Years26.31%
Last Year105.22%

BCRX Recent Earnings

BioCryst Pharmaceuticals, Inc. (BCRX) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 10/12 qtrs (83%)
Q2 2026Latest
May 6, 2026
Metric
Actual
Est
EPS
$0.03-150.0%
$0.06
Rev
$156M+3.5%
$151M
Q1 2026
Feb 26, 2026
Metric
Actual
Est
EPS
$1.12+1500.0%
$0.07
Rev
$407M+168.7%
$151M
Q4 2025
Nov 3, 2025
Metric
Actual
Est
EPS
$0.06-14.3%
$0.07
Rev
$159M+5.3%
$151M
Q3 2025
Aug 4, 2025
Metric
Actual
Est
EPS
$0.15+400.0%
$0.03
Rev
$163M+9.2%
$150M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 6, 2026
$0.03vs $0.06-150.0%
$156Mvs $151M+3.5%
Q1 2026Feb 26, 2026
$1.12vs $0.07+1500.0%
$407Mvs $151M+168.7%
Q4 2025Nov 3, 2025
$0.06vs $0.07-14.3%
$159Mvs $151M+5.3%
Q3 2025Aug 4, 2025
$0.15vs $0.03+400.0%
$163Mvs $150M+9.2%
Based on last 12 quarters of dataView full earnings history →

Latest BCRX News

Recent stock market news and headlines for BioCryst Pharmaceuticals, Inc. (BCRX)

GlobeNewsWire·6 days ago
BioCryst Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

RESEARCH TRIANGLE PARK, N.C., July 02, 2026 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) today announced that the compensation committee of BioCryst's board of directors granted nine newly-hired employees stock options to purchase an aggregate of 33,950 shares, and restricted stock units (RSUs) covering an aggregate of 91,750 shares, of BioCryst common stock. The options and RSUs were granted as of July 1, 2026, as inducements material to each employee entering into employment with BioCryst. The options and RSUs were granted in accordance with Nasdaq Listing Rule 5635(c)(4).

Reuters·Jun 29, 2026
BioCryst scraps internal drug discovery programs, leans on partnerships to cut costs

BioCryst Pharmaceuticals said on Monday it would wind down its internal drug discovery programs and close ​its Alabama research facility by the end of ‌2026, as it pivots to external partnerships to build its rare-disease pipeline and streamline expenses.

GlobeNewsWire·Jun 29, 2026
BioCryst Sharpens Scientific Focus on External Innovation with Wind Down of Internal Discovery Programs and Closure of Birmingham Research Facility

—Advances strategic shift toward a disciplined research model prioritizing external innovation to accelerate rare disease pipeline growth—

Seeking Alpha·Jun 15, 2026
BioCryst Pharmaceuticals: Management's Plans For Multibillion HAE Franchise Add Up

BioCryst Pharmaceuticals, Inc. is upgraded to Buy, reflecting strong execution in HAE and a compelling pipeline with Orladeyo and navenibart. BCRX targets $1.8bn in revenues and $1bn in cash by 2033, leveraging best-in-class efficacy and less frequent dosing for navenibart to challenge market incumbents. Recent Q1 results showed 11% YoY Orladeyo revenue growth, robust non-GAAP profitability, and reaffirmed 2026 guidance, suggesting valuation remains attractive.

Peers Comparison

Key metrics vs top competitors for BioCryst Pharmaceuticals, Inc. (BCRX)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
BCRX logoBCRXBioCryst Pharmaceuticals, Inc.Current
$10.99$2.31B9.0894.1%30.16%——
RARE logoRAREUltragenyx Pharmaceutical Inc.
$35.87$3.53B-6.1520.13%-91.03%——
FOLD logoFOLDAmicus Therapeutics, Inc.
$14.49$4.55B-164.8520.05%-4.27%-12.02%—
ACAD logoACADACADIA Pharmaceuticals Inc.
$26.20$4.49B11.4411.87%34.3%35.65%—
PTCT logoPTCTPTC Therapeutics, Inc.
$89.20$7.4B11.47114.51%-22.58%——
KYMR logoKYMRKymera Therapeutics, Inc.
$119.24$9.74B-32.31-16.72%-612.17%-25.02%—

Compare BCRX vs Peers

BioCryst Pharmaceuticals, Inc. (BCRX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RARE

Most directly comparable listed peer for BCRX.

Scale Benchmark

vs ARGX

Larger-name benchmark to compare BCRX against a more recognizable public peer.

Peer Set

Compare Top 5

vs RARE, FOLD, ACAD, PTCT

BCRX SEC Filings & Documents

BioCryst Pharmaceuticals, Inc. (BCRX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 6, 2026·SEC

Material company update

May 4, 2026·SEC

Material company update

Feb 26, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 25, 2025·SEC

FY 2024

Feb 27, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 6, 2026·SEC

FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 5, 2025·SEC

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BCRX Frequently Asked Questions

BioCryst Pharmaceuticals, Inc. (BCRX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is BioCryst Pharmaceuticals, Inc.'s revenue?

BioCryst Pharmaceuticals, Inc. (BCRX) reported $885.7M in revenue for fiscal year 2025. This represents a 32704% increase from $2.7M in 1996.

How fast is BioCryst Pharmaceuticals, Inc. growing?

BioCryst Pharmaceuticals, Inc. (BCRX) grew revenue by 94.1% over the past year. This is strong growth.

Is BCRX profitable?

BioCryst Pharmaceuticals, Inc. (BCRX) reported a net loss of $458.0M for fiscal year 2025.

Dividend & Returns
What is BioCryst Pharmaceuticals, Inc.'s free cash flow?

BioCryst Pharmaceuticals, Inc. (BCRX) generated $293.6M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

What if you invested $1,000 in BCRX back in 1996?

Total return calculator · dividends reinvested · 30+ years of data

See returns →