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TSHATaysha Gene Therapies, Inc.
$6.50$1.9B
Overview & Verdict
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TSHA logoTaysha Gene Therapies, Inc.(TSHA)Earnings, Financials & Key Ratios

TSHA•NASDAQ
$6.50
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutTaysha Gene Therapies, Inc., a gene therapy company, focuses on developing and commercializing adeno-associated virus-based gene therapies for the treatment of monogenic diseases of the central nervous system. It primarily develops TSHA-120 for the treatment of giant axonal neuropathy; TSHA-102 for the treatment of Rett syndrome; TSHA-121 for the treatment of CLN1 disease; TSHA-118 for the treatment of CLN1 disease; TSHA-105 foe the treatment of for SLC13A5 Deficiency; and TSHA-101 for the treatment of GM2 gangliosidosis. Taysha Gene Therapies, Inc. has a strategic partnership with The University of Texas Southwestern Medical Center to develop and commercialize transformative gene therapy treatments. The company was incorporated in 2019 and is based in Dallas, Texas.Show more
  • Revenue$10M+17.3%
  • EBITDA-$109M-21.2%
  • Net Income-$109M-22.1%
  • EPS (Diluted)-0.34+5.6%
  • Gross Margin100%
  • EBITDA Margin-1118.93%-3.4%
  • Operating Margin-1130.65%-3.0%
  • Net Margin-1115.27%-4.1%
  • ROE-68.45%+43.9%

TSHA Price & Volume

Taysha Gene Therapies, Inc. (TSHA) stock price & volume — 10-year historical chart

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Clinical Development Intensity Outpaces Revenue Generation Potential

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Adequate
Cash Flow:Burning
Primary Risk:Binary clinical trial dependency

Key Thesis Takeaways

  • Taysha Gene Therapies remains a high-risk, clinical-stage biotechnology firm whose valuation is tethered to the binary success of its miRARE platform rather than recurring commercial revenue.
  • While the company has successfully reduced its total debt from $61.1M in 2023Q4 to $17.8M in 2026Q1, the persistent reliance on milestone-driven income creates significant volatility in financial performance.
  • Investors should monitor the company's ability to manage its $40.9M quarterly free cash flow burn rate as it advances its lead pipeline candidates through critical regulatory milestones.

Verdict Logic

the company's reliance on binary clinical outcomes and a persistent quarterly cash burn of $40.9M in 2026Q1 present substantial risks that outweigh current valuation multiples.

TSHA Growth Metrics

Taysha Gene Therapies, Inc. (TSHA) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years57.49%
TTM3.42%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-49.69%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-7.29%

Return on Capital

10 Years-69.82%
5 Years-76.95%
3 Years-63.12%
Last Year-49.01%

TSHA Recent Earnings

Taysha Gene Therapies, Inc. (TSHA) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 5/12 qtrs (42%)●Beat Revenue 7/12 qtrs (70%)
Q2 2026Latest
May 6, 2026
Metric
Actual
Est
EPS
$0.12-20.0%
$0.10
Rev
—
$755,556
Q2 2026
Mar 19, 2026
Metric
Actual
Est
EPS
$0.08+27.3%
$0.11
Rev
$5M+144.5%
$2M
Q4 2025
Nov 4, 2025
Metric
Actual
Est
EPS
$0.09+0.0%
$0.09
Rev
—
$2M
Q3 2025
Aug 12, 2025
Metric
Actual
Est
EPS
$0.09-28.6%
$0.07
Rev
$2M+14.9%
$2M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 6, 2026
$0.12vs $0.10-20.0%
—vs $755,556
Q2 2026Mar 19, 2026
$0.08vs $0.11+27.3%
$5Mvs $2M+144.5%
Q4 2025Nov 4, 2025
$0.09vs $0.09+0.0%
—vs $2M
Q3 2025Aug 12, 2025
$0.09vs $0.07-28.6%
$2Mvs $2M+14.9%
Based on last 12 quarters of dataView full earnings history →

Latest TSHA News

Recent stock market news and headlines for Taysha Gene Therapies, Inc. (TSHA)

Seeking Alpha·Jun 30, 2026
Taysha: 'Buy' On Interim Analysis Of TSHA-102 First Half 2027 And Broad Label Potential

Taysha Gene Therapies (TSHA) remains a "Buy," driven by strong TSHA-102 data in Rett Syndrome and pivotal trial progress. TSHA-102 achieved 100% response rate at 12 months in Part A, surpassing the 33% response threshold needed for regulatory submission. Alignment with the FDA on pivotal trial endpoints and interim analysis could enable an accelerated BLA submission in 1H 2027.

GlobeNewsWire·Jun 25, 2026
Taysha Gene Therapies Announces Multiple Presentations Highlighting its TSHA-102 Clinical Program at the 2026 IRSF Rett Syndrome Scientific Meeting

Recently disclosed longer-term REVEAL Part A data demonstrated broad, multi-domain functional impact that deepened over time through ≥12 months post-TSHA-102 regardless of age or disease severity

GlobeNewsWire·Jun 25, 2026
Taysha Gene Therapies Announces Pricing of Public Offering of Common Stock and Pre-Funded Warrants

DALLAS, June 24, 2026 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA) (Taysha or the Company), a clinical-stage biotechnology company focused on advancing adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system (CNS), today announced the pricing of an underwritten public offering of 32,500,001 shares of its common stock at a price to the public of $6.00 per share and, in lieu of common stock to certain investors that so choose, pre-funded warrants to purchase 833,333 shares of its common stock at an offering price of $5.999 per pre-funded warrant, in each case before underwriting discounts and commissions. All of the securities are being offered by Taysha. In addition, Taysha has granted the underwriters a 30-day option to purchase up to an additional 5,000,000 shares of common stock at the public offering price, less underwriting discounts and commissions. The gross proceeds from the offering to Taysha are expected to be approximately $200.0 million, before deducting underwriting discounts and commissions and other offering expenses, excluding any exercise of the underwriters' option to purchase additional shares. The offering is expected to close on or about June 26, 2026, subject to customary closing conditions.

GlobeNewsWire·Jun 24, 2026
Taysha Gene Therapies Announces Proposed Public Offering of Common Stock and Pre-Funded Warrants

DALLAS, June 24, 2026 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA) (Taysha or the Company), a clinical-stage biotechnology company focused on advancing adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system (CNS), today announced that it has commenced an underwritten public offering of $200.0 million shares of its common stock and, in lieu of common stock to certain investors that so choose, pre-funded warrants to purchase shares of its common stock. All of the securities will be offered by Taysha. Taysha also intends to grant the underwriters a 30-day option to purchase up to an additional 15% of the shares of its common stock offered in the public offering under the same terms and conditions (including shares underlying the pre-funded warrants). The offering is subject to market conditions, and there can be no assurance as to whether or when the offering may be completed, or the actual size or terms of the offering.

Seeking Alpha·Jun 22, 2026
Taysha Gene Therapies, Inc. (TSHA) Discusses Longer-Term Clinical Data and Program Update for TSHA-102 in Rett Syndrome Transcript

Taysha Gene Therapies, Inc. (TSHA) Discusses Longer-Term Clinical Data and Program Update for TSHA-102 in Rett Syndrome Transcript

Peers Comparison

Key metrics vs top competitors for Taysha Gene Therapies, Inc. (TSHA)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
TSHA logoTSHATaysha Gene Therapies, Inc.Current
$6.50$1.87B-19.1217.28%-1115.27%-68.45%—
SRPT logoSRPTSarepta Therapeutics, Inc.
$19.79$2.09B-2.7815.58%2.98%4.89%—
RARE logoRAREUltragenyx Pharmaceutical Inc.
$35.87$3.53B-6.1520.13%-91.03%——
FOLD logoFOLDAmicus Therapeutics, Inc.
$14.49$4.55B-164.8520.05%-4.27%-12.02%—
ARWR logoARWRArrowhead Pharmaceuticals, Inc.
$86.97$12.25B-7128.6923258.15%-48.38%-55.09%—
RCKT logoRCKTRocket Pharmaceuticals, Inc.
$4.07$444.42M-2.02——-70.79%—

Compare TSHA vs Peers

Taysha Gene Therapies, Inc. (TSHA) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs SRPT

Most directly comparable listed peer for TSHA.

Scale Benchmark

vs VRTX

Larger-name benchmark to compare TSHA against a more recognizable public peer.

Peer Set

Compare Top 5

vs SRPT, RARE, FOLD, ARWR

TSHA SEC Filings & Documents

Taysha Gene Therapies, Inc. (TSHA) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 6, 2026·SEC

Material company update

Mar 19, 2026·SEC

Material company update

Nov 4, 2025·SEC

10-K Annual Reports

3
FY 2026

Mar 19, 2026·SEC

FY 2025

Feb 26, 2025·SEC

FY 2024

Mar 19, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 6, 2026·SEC

FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 12, 2025·SEC

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TSHA Frequently Asked Questions

Taysha Gene Therapies, Inc. (TSHA) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Taysha Gene Therapies, Inc.'s revenue?

Taysha Gene Therapies, Inc. (TSHA) reported $7.5M in revenue for fiscal year 2025.

How fast is Taysha Gene Therapies, Inc. growing?

Taysha Gene Therapies, Inc. (TSHA) grew revenue by 17.3% over the past year. This is strong growth.

Is TSHA profitable?

Taysha Gene Therapies, Inc. (TSHA) reported a net loss of $129.9M for fiscal year 2025.

Dividend & Returns
What is TSHA's return on equity?

Taysha Gene Therapies, Inc. (TSHA) has a return on equity (ROE) of -68.5%. Negative ROE indicates the company is unprofitable.

What is Taysha Gene Therapies, Inc.'s free cash flow?

Taysha Gene Therapies, Inc. (TSHA) had negative free cash flow of $112.3M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in TSHA back in 2019?

Total return calculator · dividends reinvested · 7+ years of data

See returns →