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ARWRArrowhead Pharmaceuticals, Inc.
$86.97$12.3B
Overview & Verdict
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ARWR logoArrowhead Pharmaceuticals, Inc.(ARWR)Earnings, Financials & Key Ratios

ARWR•NASDAQ
$86.97
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryRNA and Genome Editing Developers
AboutArrowhead Pharmaceuticals, Inc. develops medicines for the treatment of intractable diseases in the United States. The company's products in pipeline includes ARO-AAT, a RNA interference (RNAi) therapeutic candidate that is in Phase II clinical trial for the treatment of liver diseases associated with alpha-1 antitrypsin deficiency; ARO-APOC3, which is in phase 2b and one phase 3 clinical trial to treat hypertriglyceridemia; ARO-ANG3 that is in Phase 2b clinical trial to reduce production of angiopoietin-like protein 3; ARO-HSD, which is in Phase 1/2a clinical trial to treat liver diseases; ARO-ENaC, which is in a Phase 1/2a clinical trial to reduce production of the epithelial sodium channel alpha subunit in the airways of the lung; ARO-C3 for the treatment of complement-mediated disease that is in Phase 1/2a clinical trial; ARO-Lung2 for the treatment of chronic obstructive pulmonary disorder; ARO-DUX4 for the treatment of facioscapulohumeral muscular dystrophy; ARO-XDH to treat uncontrolled gout; ARO-COV for the treatment of COVID-19 and other pulmonary-borne pathogens; and ARO-HIF2, which is in phase 1b clinical trial to treat clear cell renal cell carcinoma. It is also involved in the development of JNJ-3989, a subcutaneously administered RNAi therapeutic candidate to treat chronic hepatitis B virus infection; Olpasiran to reduce the production of apolipoprotein A; and ARO-AMG1 for treating genetically validated cardiovascular targets. Arrowhead Pharmaceuticals, Inc. has a license and research collaboration agreement with Janssen Pharmaceuticals, Inc. to develop ARO-JNJ1, ARO-JNJ2, and ARO-JNJ3 RNAi therapeutics for liver-expressed targets; and license and research collaboration agreement with Takeda Pharmaceuticals U.S.A., Inc. to develop RNAi therapeutic candidate as a treatment for liver disease. Arrowhead Pharmaceuticals, Inc. was incorporated in 1989 and is headquartered in Pasadena, California.Show more
  • Revenue$829M+23258.2%
  • EBITDA$122M+121.0%
  • Net Income-$2M+99.7%
  • EPS (Diluted)-0.01+99.8%
  • Gross Margin100%+123.6%
  • EBITDA Margin14.74%+100.1%
  • Operating Margin11.86%+100.1%
  • Net Margin-0.2%+100.0%
  • ROE-0.47%+99.8%

ARWR Price & Volume

Arrowhead Pharmaceuticals, Inc. (ARWR) stock price & volume — 10-year historical chart

Loading chart...

Milestone Dependency Masks Structural Clinical Burn Risk

Investment Thesis • Updated 2026Q2

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Liquidity exhaustion from R&D

Key Thesis Takeaways

  • Arrowhead Pharmaceuticals faces a precarious financial outlook defined by extreme revenue volatility, where quarterly top-line swings of over 100% are driven by non-recurring milestone payments rather than sustainable commercial demand.
  • While the company maintains a sophisticated RNAi platform, the persistent R&D burn—averaging over $150 million per quarter—outpaces internal cash generation, necessitating increased reliance on debt financing.
  • Investors should remain cautious as the firm's liquidity runway appears thin, with a debt-to-equity ratio that spiked to 2.29 in 2026Q2, signaling heightened financial risk as the company attempts to bridge the gap to late-stage clinical success.

Verdict Logic

the company's reliance on non-recurring milestone payments to cover quarterly R&D expenditures exceeding $167 million creates a high-risk liquidity profile that warrants extreme caution.

ARWR Growth Metrics

Arrowhead Pharmaceuticals, Inc. (ARWR) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years115.61%
5 Years56.63%
3 Years50.52%
TTM14.09%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-109.01%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-50.7%

Return on Capital

10 Years-32.16%
5 Years-31.26%
3 Years-31.94%
Last Year8.83%

ARWR Recent Earnings

Arrowhead Pharmaceuticals, Inc. (ARWR) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 2/12 qtrs (17%)●Beat Revenue 3/12 qtrs (30%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$0.93+14.7%
$1.09
Rev
$74M-0.1%
$74M
Q1 2026
Feb 5, 2026
Metric
Actual
Est
EPS
$0.22-63.3%
$0.60
Rev
$264M+23.4%
$214M
Q4 2025
Nov 25, 2025
Metric
Actual
Est
EPS
$0.18-61.3%
$0.11
Rev
$256M+46.3%
$175M
Q3 2025
Aug 7, 2025
Metric
Actual
Est
EPS
$1.26-34.0%
$0.94
Rev
$28M-82.0%
$154M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$0.93vs $1.09+14.7%
$74Mvs $74M-0.1%
Q1 2026Feb 5, 2026
$0.22vs $0.60-63.3%
$264Mvs $214M+23.4%
Q4 2025Nov 25, 2025
$0.18vs $0.11-61.3%
$256Mvs $175M+46.3%
Q3 2025Aug 7, 2025
$1.26vs $0.94-34.0%
$28Mvs $154M-82.0%
Based on last 12 quarters of dataView full earnings history →

Latest ARWR News

Recent stock market news and headlines for Arrowhead Pharmaceuticals, Inc. (ARWR)

Seeking Alpha·Jun 29, 2026
Arrowhead Pharmaceuticals, Inc. (ARWR) Discusses Cardiometabolic Pipeline and Clinical Development Programs Transcript

Arrowhead Pharmaceuticals, Inc. (ARWR) Discusses Cardiometabolic Pipeline and Clinical Development Programs Transcript

24/7 Wall Street·Jun 25, 2026
3 Under-the-Radar Biotech Takeover Targets for the Next Pharma Buying Spree

Large-cap pharma is back in the deal market. AbbVie's (NASDAQ: ABBV | ABBV Price Prediction) pending acquisition of Apogee Therapeutics signaled that big buyers will pay up for de-risked clinical assets.

Business Wire·Jun 22, 2026
Arrowhead Pharmaceuticals Receives Marketing Authorization in the European Union for REDEMPLO® (plozasiran) to Reduce Triglycerides in Adults with Familial Chylomicronemia Syndrome (FCS)

PASADENA, Calif.--(BUSINESS WIRE)---- $arwr--Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) today announced that the European Commission (EC) has formally granted marketing authorization for REDEMPLO® (plozasiran), a small interfering RNA (siRNA) medicine, as an adjunct to diet to reduce triglyceride levels in adult patients with familial chylomicronemia syndrome (FCS). REDEMPLO is the first and only siRNA medicine authorized by the EC for adults with FCS, diagnosed either by the presence of clinical crit.

Business Wire·Jun 18, 2026
Arrowhead Pharmaceuticals to Host a Webinar on its Cardiometabolic Pipeline as Part I of the 2026 Summer Series of R&D Webinars

PASADENA, Calif.--(BUSINESS WIRE)---- $arwr--Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) today announced its plan to host a 2026 Summer Series of R&D webinars that highlight multiple clinical stage RNA interference (RNAi) based medicines that utilize the company's proprietary Targeted RNAi Molecule (TRiM™) platform. Each webinar in the Summer Series will focus on a specific therapeutic area and will feature presentations by Arrowhead team members about the company's clinical candidates and externa.

Peers Comparison

Key metrics vs top competitors for Arrowhead Pharmaceuticals, Inc. (ARWR)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Current
$86.97$12.25B-7128.6923258.15%-0.2%-0.47%—
ALNY logoALNYAlnylam Pharmaceuticals, Inc.
$321.59$42.91B138.0265.19%13.46%98.29%—
NTLA logoNTLAIntellia Therapeutics, Inc.
$17.43$1.96B-4.5716.92%-597.04%-57.27%—
BEAM logoBEAMBeam Therapeutics Inc.
$37.92$3.9B-46.81120.01%-49.17%-5.89%—
SRPT logoSRPTSarepta Therapeutics, Inc.
$19.79$2.09B-2.7815.58%2.98%4.89%—
IONS logoIONSIonis Pharmaceuticals, Inc.
$86.33$14.27B-36.2733.87%-30.87%-58.57%—

Compare ARWR vs Peers

Arrowhead Pharmaceuticals, Inc. (ARWR) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ALNY

Most directly comparable listed peer for ARWR.

Scale Benchmark

vs JNJ

Larger-name benchmark to compare ARWR against a more recognizable public peer.

Peer Set

Compare Top 5

vs ALNY, NTLA, BEAM, SRPT

ARWR SEC Filings & Documents

Arrowhead Pharmaceuticals, Inc. (ARWR) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 7, 2026·SEC

Material company update

Mar 20, 2026·SEC

Material company update

Feb 5, 2026·SEC

10-K Annual Reports

3
FY 2025

Nov 25, 2025·SEC

FY 2024

Nov 26, 2024·SEC

FY 2023

Nov 29, 2023·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2026

Feb 5, 2026·SEC

FY 2025

Aug 7, 2025·SEC

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ARWR Frequently Asked Questions

Arrowhead Pharmaceuticals, Inc. (ARWR) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Arrowhead Pharmaceuticals, Inc.'s revenue?

Arrowhead Pharmaceuticals, Inc. (ARWR) reported $622.0M in revenue for fiscal year 2025. This represents a 812028% increase from $0.1M in 1997.

How fast is Arrowhead Pharmaceuticals, Inc. growing?

Arrowhead Pharmaceuticals, Inc. (ARWR) grew revenue by 23258.2% over the past year. This is strong growth.

Is ARWR profitable?

Arrowhead Pharmaceuticals, Inc. (ARWR) reported a net loss of $300.9M for fiscal year 2025.

Dividend & Returns
What is ARWR's return on equity?

Arrowhead Pharmaceuticals, Inc. (ARWR) has a return on equity (ROE) of -0.5%. Negative ROE indicates the company is unprofitable.

What is Arrowhead Pharmaceuticals, Inc.'s free cash flow?

Arrowhead Pharmaceuticals, Inc. (ARWR) had negative free cash flow of $50.9M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ARWR back in 1997?

Total return calculator · dividends reinvested · 29+ years of data

See returns →