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AGIOAgios Pharmaceuticals, Inc.
$44.01$2.6B
Overview & Verdict
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AGIO logoAgios Pharmaceuticals, Inc.(AGIO)Earnings, Financials & Key Ratios

AGIO•NASDAQ
$44.01
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Rare Disease Biopharma
AboutAgios Pharmaceuticals, Inc., a biopharmaceutical company, engages in the discovery and development of medicines in the field of cellular metabolism and adjacent areas of biology. The company offers PYRUKYND (mitapivat) an activator of both wild-type and a variety of mutant pyruvate kinase, PK, enzymes for the treatment of hemolytic anemias; and AG-946 that is in Phase I clinical study for treating hemolytic anemias and other indications. Agios Pharmaceuticals, Inc. was incorporated in 2007 and is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$54M+48.0%
  • EBITDA-$467M-11.2%
  • Net Income-$413M-161.3%
  • EPS (Diluted)-7.12-161.2%
  • Gross Margin78.67%-11.2%
  • EBITDA Margin-864.28%+24.9%
  • Operating Margin-873.87%+25.1%
  • Net Margin-764.01%-141.4%
  • ROE-30.2%-152.7%

AGIO Price & Volume

Agios Pharmaceuticals, Inc. (AGIO) stock price & volume — 10-year historical chart

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Accelerating Revenue Growth Faces Severe Liquidity Constraints

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Accelerating
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Imminent liquidity shortfall

Key Thesis Takeaways

  • Agios Pharmaceuticals is currently navigating a high-stakes commercial transition for its metabolic platform, evidenced by a 137.7% year-over-year revenue growth rate in 2026Q1.
  • While the company maintains robust gross margins of 87.1%, the persistent quarterly operating losses exceeding $100 million create a precarious financial runway.
  • Investors should monitor the company's ability to manage its $660.8 million accumulated deficit and reliance on external capital to sustain its intensive R&D pipeline.

Verdict Logic

the company's precarious liquidity position, evidenced by a cash balance of only $113.6 million against quarterly operating losses of $110 million, suggests an imminent risk of further shareholder dilution.

AGIO Growth Metrics

Agios Pharmaceuticals, Inc. (AGIO) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-0.9%
5 Years-
3 Years55.97%
TTM78.34%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-163.46%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-164.22%

Return on Capital

10 Years-43.27%
5 Years-34.53%
3 Years-35.59%
Last Year-33.76%

AGIO Recent Earnings

Agios Pharmaceuticals, Inc. (AGIO) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 6/12 qtrs (50%)
Q2 2026Latest
Apr 29, 2026
Metric
Actual
Est
EPS
$1.69+6.6%
$1.81
Rev
$21M+56.0%
$13M
Q1 2026
Feb 12, 2026
Metric
Actual
Est
EPS
$1.85+6.1%
$1.97
Rev
$20M+65.1%
$12M
Q4 2025
Oct 30, 2025
Metric
Actual
Est
EPS
$1.78+7.8%
$1.93
Rev
$13M+10.1%
$12M
Q3 2025
Jul 31, 2025
Metric
Actual
Est
EPS
$1.93-10.9%
$1.74
Rev
$12M+21.2%
$10M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestApr 29, 2026
$1.69vs $1.81+6.6%
$21Mvs $13M+56.0%
Q1 2026Feb 12, 2026
$1.85vs $1.97+6.1%
$20Mvs $12M+65.1%
Q4 2025Oct 30, 2025
$1.78vs $1.93+7.8%
$13Mvs $12M+10.1%
Q3 2025Jul 31, 2025
$1.93vs $1.74-10.9%
$12Mvs $10M+21.2%
Based on last 12 quarters of dataView full earnings history →

Latest AGIO News

Recent stock market news and headlines for Agios Pharmaceuticals, Inc. (AGIO)

GlobeNewsWire·Jun 29, 2026
Agios to Host Second Quarter 2026 Financial Results Conference Call and Webcast on July 30 at 8:00 a.m. ET

CAMBRIDGE, Mass., June 29, 2026 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a commercial-stage biopharmaceutical company focused on delivering innovative medicines for patients with rare diseases, today announced the company will host a conference call and live webcast on Thursday, July 30, 2026, at 8:00 a.m.

Zacks Investment Research·Jun 18, 2026
AGIO Stock Surges 35% in Six Months: What's Driving It?

Agios' shares rose 35% in six months as Aqvesme gains traction, mitapivat expands globally and new ITP rights add to its rare blood disease push.

Peers Comparison

Key metrics vs top competitors for Agios Pharmaceuticals, Inc. (AGIO)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
AGIO logoAGIOAgios Pharmaceuticals, Inc.Current
$44.01$2.62B-6.1848.03%-764.01%-30.2%—
IONS logoIONSIonis Pharmaceuticals, Inc.
$86.33$14.27B-36.2733.87%-30.87%-58.57%—
PTCT logoPTCTPTC Therapeutics, Inc.
$89.20$7.4B11.47114.51%-22.58%——
RARE logoRAREUltragenyx Pharmaceutical Inc.
$35.87$3.53B-6.1520.13%-91.03%——
FOLD logoFOLDAmicus Therapeutics, Inc.
$14.49$4.55B-164.8520.05%-4.27%-12.02%—
IMVT logoIMVTImmunovant, Inc.
$40.09$8.23B-14.47——-68.16%—

Compare AGIO vs Peers

Agios Pharmaceuticals, Inc. (AGIO) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IONS

Most directly comparable listed peer for AGIO.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare AGIO against a more recognizable public peer.

Peer Set

Compare Top 5

vs IONS, PTCT, RARE, FOLD

AGIO SEC Filings & Documents

Agios Pharmaceuticals, Inc. (AGIO) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 29, 2026·SEC

Material company update

Feb 12, 2026·SEC

Material company update

Jan 12, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 12, 2026·SEC

FY 2025

Feb 13, 2025·SEC

FY 2024

Feb 15, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Apr 29, 2026·SEC

FY 2025

Oct 30, 2025·SEC

FY 2025

Jul 31, 2025·SEC

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AGIO Frequently Asked Questions

Agios Pharmaceuticals, Inc. (AGIO) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Agios Pharmaceuticals, Inc.'s revenue?

Agios Pharmaceuticals, Inc. (AGIO) reported $66.0M in revenue for fiscal year 2025. This represents a 202% increase from $21.8M in 2011.

How fast is Agios Pharmaceuticals, Inc. growing?

Agios Pharmaceuticals, Inc. (AGIO) grew revenue by 48.0% over the past year. This is strong growth.

Is AGIO profitable?

Agios Pharmaceuticals, Inc. (AGIO) reported a net loss of $422.6M for fiscal year 2025.

Dividend & Returns
What is AGIO's return on equity?

Agios Pharmaceuticals, Inc. (AGIO) has a return on equity (ROE) of -30.2%. Negative ROE indicates the company is unprofitable.

What is Agios Pharmaceuticals, Inc.'s free cash flow?

Agios Pharmaceuticals, Inc. (AGIO) had negative free cash flow of $384.7M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in AGIO back in 2011?

Total return calculator · dividends reinvested · 15+ years of data

See returns →