Latest Ratios: P/E Ratio -5.3x · EV/EBITDA N/A · ROE -30.2%. (2011–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $2.2B | $1.6B | $1.9B | $1.2B | $1.5B | $2.0B | $3.0B | $2.9B | $2.6B | $2.7B | $1.6B |
| Enterprise Value | $2.2B | $1.6B | $1.9B | $1.2B | $1.5B | $1.9B | $3.0B | $2.9B | $1.8B | $2.1B | $1.1B |
| P/E Ratio → | -5.25 | — | 2.82 | — | — | — | — | — | — | — | — |
| P/S Ratio | 41.16 | 29.21 | 52.12 | 46.21 | 108.04 | — | — | 24.30 | 28.05 | 61.92 | 23.36 |
| P/B Ratio | 1.82 | 1.32 | 1.23 | 1.53 | 1.40 | 1.54 | 7.48 | 4.47 | 3.85 | 7.09 | 4.55 |
| P/FCF | — | — | — | — | — | — | — | — | — | — | 57.00 |
| P/OCF | — | — | — | — | — | — | — | — | — | — | 42.34 |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 28.71 | 51.59 | 45.60 | 104.28 | — | — | 24.57 | 19.52 | 48.72 | 15.15 |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — | — |
| EV / FCF | — | — | — | — | — | — | — | — | — | — | 36.97 |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 78.7% | 78.7% | 88.6% | 64.6% | 88.0% | — | — | 98.9% | 98.5% | -580.5% | -215.0% |
| Operating Margin | -873.9% | -873.9% | -1166.5% | -1459.5% | -2732.1% | — | — | -361.6% | -384.0% | -745.8% | -287.6% |
| Net Profit Margin | -764.0% | -764.0% | 1845.9% | -1312.6% | -1627.8% | — | — | -349.0% | -366.6% | -731.6% | -284.0% |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -30.2% | -30.2% | 57.3% | -36.8% | -19.4% | 189.7% | -63.0% | -62.0% | -65.1% | -85.7% | -56.4% |
| ROA | -27.9% | -27.9% | 51.8% | -32.4% | -17.3% | 140.1% | -37.5% | -47.0% | -47.0% | -51.0% | -38.2% |
| ROIC | -26.3% | -26.3% | -27.6% | -31.9% | -26.1% | -36.3% | -48.0% | -115.1% | — | — | — |
| ROCE | -33.8% | -33.8% | -34.7% | -38.3% | -30.5% | -35.4% | -43.2% | -54.6% | -56.4% | -61.1% | -44.8% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.05 | 0.05 | 0.04 | 0.09 | 0.08 | 0.08 | 0.26 | 0.18 | — | — | — |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | -0.02 | -0.01 | -0.02 | -0.05 | -0.08 | -0.06 | 0.05 | -1.17 | -1.51 | -1.60 |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| Debt / FCF | — | — | — | — | — | — | — | — | — | — | -20.02 |
| Interest Coverage | — | — | — | — | — | — | -18.47 | — | — | — | — |
Net cash position: cash ($89M) exceeds total debt ($62M)
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 11.46 | 11.46 | 11.90 | 12.27 | 13.30 | 17.79 | 6.74 | 6.59 | 6.56 | 4.69 | 6.33 |
| Quick Ratio | 11.06 | 11.06 | 11.56 | 11.99 | 13.16 | 17.79 | 6.74 | 6.51 | 6.55 | 6.20 | 6.70 |
| Cash Ratio | 10.39 | 10.39 | 11.01 | 11.43 | 12.50 | 17.05 | 6.07 | 6.08 | 8.61 | 5.98 | 6.49 |
| Asset Turnover | — | 0.04 | 0.02 | 0.03 | 0.01 | — | — | 0.13 | 0.11 | 0.07 | 0.11 |
| Inventory Turnover | 0.35 | 0.35 | 0.15 | 0.50 | 0.20 | — | — | 0.18 | 1.61 | — | — |
| Days Sales Outstanding | — | 71.46 | 41.09 | 38.24 | 56.54 | — | — | 47.42 | 40.38 | 31.14 | 43.42 |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | 35.4% | — | — | — | — | — | — | — | — |
| FCF Yield | — | — | — | — | — | — | — | — | — | — | 1.8% |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 40.4% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 40.4% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Shares Outstanding | — | $58M | $58M | $56M | $55M | $60M | $69M | $60M | $57M | $47M | $39M |
Imminent liquidity shortfall
Based on current market data, AGIO trades at a P/S multiple of 41.72, a figure that appears to price in significant future growth potential rather than current earnings, as the company continues to report negative net margins according to the latest quarterly financial statements.
The elevated P/S ratio suggests that investors are valuing the company as a high-growth platform rather than a traditional commercial entity. This valuation implies that the market expects rapid revenue scaling to eventually justify the current price, though the lack of positive earnings makes traditional P/E metrics largely irrelevant for assessing fundamental value.
As reported in financial statements, AGIO's ROIC has remained consistently negative, hovering around -7.6% in 2026Q1, which indicates that the company is currently destroying shareholder value through its heavy investment in clinical development and commercial infrastructure relative to its generated returns.
The persistent negative ROIC reflects the high cost of capital required to sustain the company's metabolic research pipeline. Until the commercial revenue from PYRUKYND can scale to cover these fixed R&D and SG&A costs, the company will likely continue to struggle with generating positive returns on its invested capital.
According to recent quarterly filings, AGIO's asset turnover remains extremely low at 0.02, highlighting the company's reliance on intangible assets and clinical progress rather than physical asset utilization to drive its long-term growth strategy within the rare disease market.
The high cash conversion cycle, which reached 660 days in 2026Q1, suggests significant inefficiencies in managing inventory and receivables. Investors should monitor whether these metrics improve as the company matures, as the current turnover levels indicate a heavy reliance on external funding to maintain operations.
Based on reported figures, AGIO maintains a very low D/E ratio of 0.03, suggesting that the company has avoided significant debt financing, yet the lack of interest coverage data underscores the company's reliance on equity-based funding to sustain its ongoing operations.
While the low leverage profile provides some protection against interest rate volatility, it also highlights the company's dependence on equity markets for survival. The absence of meaningful debt service obligations is a positive, but it does not mitigate the fundamental risk posed by the company's high cash burn rate.
The P/E ratio is the most commonly misapplied metric for AGIO, as it obscures the company's true value by focusing on negative earnings that are heavily influenced by non-recurring R&D investments and the ongoing commercialization phase of its lead asset.
Using P/E to evaluate a pre-profitability biotech company like AGIO is fundamentally flawed because it ignores the value of the pipeline and the potential for future operating leverage. Analysts should instead focus on EV/Sales or risk-adjusted net present value models to better capture the company's long-term economic potential.
Includes 30+ ratios · 15 years · Updated daily
DCF models, multiple analysis, and analyst estimates.
10-year return with dividends reinvested.
See how regular investing compounds over time.
Compare growth, multiples, and margins vs sector.
Quick answers to the most common questions about buying AGIO stock.
Agios Pharmaceuticals, Inc.'s current P/E ratio is -5.3x. The historical average is 2.8x.
Agios Pharmaceuticals, Inc.'s return on equity (ROE) is -30.2%. The historical average is -22.8%.
Based on historical data, Agios Pharmaceuticals, Inc. is trading at a P/E of -5.3x. Compare with industry peers and growth rates for a complete picture.
Agios Pharmaceuticals, Inc. has 78.7% gross margin and -873.9% operating margin.