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AGIOAgios Pharmaceuticals, Inc.
$37.39$2.2B
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  4. Financial Ratios

Agios Pharmaceuticals, Inc. (AGIO) Financial Ratios

Latest Ratios: P/E Ratio -5.3x · EV/EBITDA N/A · ROE -30.2%. (2011–2025 historical series)

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly

AGIO Valuation Multiples

Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Market Cap$2.2B$1.6B$1.9B$1.2B$1.5B$2.0B$3.0B$2.9B$2.6B$2.7B$1.6B
Enterprise Value$2.2B$1.6B$1.9B$1.2B$1.5B$1.9B$3.0B$2.9B$1.8B$2.1B$1.1B
P/E Ratio →-5.25—2.82————————
P/S Ratio41.1629.2152.1246.21108.04——24.3028.0561.9223.36
P/B Ratio1.821.321.231.531.401.547.484.473.857.094.55
P/FCF——————————57.00
P/OCF——————————42.34

P/E links to full P/E history page with 30-year chart

AGIO EV Ratios

Enterprise-value multiples — capital-structure-neutral measures of total business value

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
EV / Revenue—28.7151.5945.60104.28——24.5719.5248.7215.15
EV / EBITDA———————————
EV / EBIT———————————
EV / FCF——————————36.97

AGIO Profitability

Margins and return-on-capital ratios measuring operating efficiency

Margins

Full margin charts and quarterly trend are on the Earnings History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Gross Margin78.7%78.7%88.6%64.6%88.0%——98.9%98.5%-580.5%-215.0%
Operating Margin-873.9%-873.9%-1166.5%-1459.5%-2732.1%——-361.6%-384.0%-745.8%-287.6%
Net Profit Margin-764.0%-764.0%1845.9%-1312.6%-1627.8%——-349.0%-366.6%-731.6%-284.0%

Return on Capital

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
ROE-30.2%-30.2%57.3%-36.8%-19.4%189.7%-63.0%-62.0%-65.1%-85.7%-56.4%
ROA-27.9%-27.9%51.8%-32.4%-17.3%140.1%-37.5%-47.0%-47.0%-51.0%-38.2%
ROIC-26.3%-26.3%-27.6%-31.9%-26.1%-36.3%-48.0%-115.1%———
ROCE-33.8%-33.8%-34.7%-38.3%-30.5%-35.4%-43.2%-54.6%-56.4%-61.1%-44.8%

AGIO Leverage & Debt

Solvency and debt-coverage ratios — lower is generally safer

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Debt / Equity0.050.050.040.090.080.080.260.18———
Debt / EBITDA———————————
Net Debt / Equity—-0.02-0.01-0.02-0.05-0.08-0.060.05-1.17-1.51-1.60
Net Debt / EBITDA———————————
Debt / FCF——————————-20.02
Interest Coverage——————-18.47————

Net cash position: cash ($89M) exceeds total debt ($62M)

AGIO Liquidity & Efficiency

Short-term solvency ratios and asset-utilisation metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Current Ratio11.4611.4611.9012.2713.3017.796.746.596.564.696.33
Quick Ratio11.0611.0611.5611.9913.1617.796.746.516.556.206.70
Cash Ratio10.3910.3911.0111.4312.5017.056.076.088.615.986.49
Asset Turnover—0.040.020.030.01——0.130.110.070.11
Inventory Turnover0.350.350.150.500.20——0.181.61——
Days Sales Outstanding—71.4641.0938.2456.54——47.4240.3831.1443.42

AGIO Shareholder Yields

Earnings, FCF, buyback, and dividend yields — total returns to shareholders

Dividends

Full dividend history and growth charts are on the Dividend History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Dividend Yield———————————
Payout Ratio———————————

Total Shareholder Return Metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Earnings Yield——35.4%————————
FCF Yield——————————1.8%
Buyback Yield0.0%0.0%0.0%0.0%0.0%40.4%0.0%0.0%0.0%0.0%0.0%
Total Shareholder Yield0.0%0.0%0.0%0.0%0.0%40.4%0.0%0.0%0.0%0.0%0.0%
Shares Outstanding—$58M$58M$56M$55M$60M$69M$60M$57M$47M$39M

Key Metrics

Growth RegimeAccelerating
ProfitabilityNegative
Balance SheetVulnerable
Cash FlowBurning
Top Statement Risk

Imminent liquidity shortfall

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2026Q1)

Premium Valuation Amidst Operating Losses

Based on current market data, AGIO trades at a P/S multiple of 41.72, a figure that appears to price in significant future growth potential rather than current earnings, as the company continues to report negative net margins according to the latest quarterly financial statements.

The elevated P/S ratio suggests that investors are valuing the company as a high-growth platform rather than a traditional commercial entity. This valuation implies that the market expects rapid revenue scaling to eventually justify the current price, though the lack of positive earnings makes traditional P/E metrics largely irrelevant for assessing fundamental value.

Capital Efficiency Constrained by R&D

As reported in financial statements, AGIO's ROIC has remained consistently negative, hovering around -7.6% in 2026Q1, which indicates that the company is currently destroying shareholder value through its heavy investment in clinical development and commercial infrastructure relative to its generated returns.

The persistent negative ROIC reflects the high cost of capital required to sustain the company's metabolic research pipeline. Until the commercial revenue from PYRUKYND can scale to cover these fixed R&D and SG&A costs, the company will likely continue to struggle with generating positive returns on its invested capital.

Working Capital Volatility and Turnover

According to recent quarterly filings, AGIO's asset turnover remains extremely low at 0.02, highlighting the company's reliance on intangible assets and clinical progress rather than physical asset utilization to drive its long-term growth strategy within the rare disease market.

The high cash conversion cycle, which reached 660 days in 2026Q1, suggests significant inefficiencies in managing inventory and receivables. Investors should monitor whether these metrics improve as the company matures, as the current turnover levels indicate a heavy reliance on external funding to maintain operations.

Minimal Debt Amidst Liquidity Pressure

Based on reported figures, AGIO maintains a very low D/E ratio of 0.03, suggesting that the company has avoided significant debt financing, yet the lack of interest coverage data underscores the company's reliance on equity-based funding to sustain its ongoing operations.

While the low leverage profile provides some protection against interest rate volatility, it also highlights the company's dependence on equity markets for survival. The absence of meaningful debt service obligations is a positive, but it does not mitigate the fundamental risk posed by the company's high cash burn rate.

Misapplication of P/E Multiples

The P/E ratio is the most commonly misapplied metric for AGIO, as it obscures the company's true value by focusing on negative earnings that are heavily influenced by non-recurring R&D investments and the ongoing commercialization phase of its lead asset.

Using P/E to evaluate a pre-profitability biotech company like AGIO is fundamentally flawed because it ignores the value of the pipeline and the potential for future operating leverage. Analysts should instead focus on EV/Sales or risk-adjusted net present value models to better capture the company's long-term economic potential.

Download Financial Ratios Data

Includes 30+ ratios · 15 years · Updated daily

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AGIO — Frequently Asked Questions

Quick answers to the most common questions about buying AGIO stock.

What is Agios Pharmaceuticals, Inc.'s P/E ratio?

Agios Pharmaceuticals, Inc.'s current P/E ratio is -5.3x. The historical average is 2.8x.

What is Agios Pharmaceuticals, Inc.'s ROE?

Agios Pharmaceuticals, Inc.'s return on equity (ROE) is -30.2%. The historical average is -22.8%.

Is AGIO stock overvalued?

Based on historical data, Agios Pharmaceuticals, Inc. is trading at a P/E of -5.3x. Compare with industry peers and growth rates for a complete picture.

What are Agios Pharmaceuticals, Inc.'s profit margins?

Agios Pharmaceuticals, Inc. has 78.7% gross margin and -873.9% operating margin.