Latest Ratios: P/E Ratio -2.9x · EV/EBITDA N/A · ROE -9.4%. (2018–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $223M | $1.2B | $3.2B | $661M | $1.2B | $985M | $553M | — | — |
| Enterprise Value | $-43783598 | $968M | $3.0B | $486M | $828M | $676M | $232M | — | — |
| P/E Ratio → | -2.90 | — | — | — | — | — | — | — | — |
| P/S Ratio | 11.95 | 66.30 | 297.77 | 69.12 | 125.49 | 105.59 | 81.46 | — | — |
| P/B Ratio | 1.07 | 5.96 | 2.28 | 1.32 | 2.00 | 2.58 | 1.81 | — | — |
| P/FCF | — | — | — | — | — | — | — | — | — |
| P/OCF | — | — | — | — | — | — | — | — | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 |
|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 52.00 | 278.22 | 50.79 | 89.74 | 72.49 | 34.23 | — | — |
| EV / EBITDA | — | — | — | — | — | — | — | — | — |
| EV / EBIT | — | — | — | — | — | — | — | — | — |
| EV / FCF | — | — | — | — | — | — | — | — | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 100.0% | 100.0% | 100.0% | 78.0% | 85.0% | -984.9% | -454.0% | 100.0% | -2125.9% |
| Operating Margin | -412.6% | -412.6% | -3477.4% | -2464.4% | -1939.6% | -1265.8% | -652.4% | -747.4% | -2769.9% |
| Net Profit Margin | -411.9% | -411.9% | -2957.7% | -2219.9% | -1886.3% | -1265.4% | -653.5% | -1066.6% | -3148.8% |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 |
|---|---|---|---|---|---|---|---|---|---|
| ROE | -9.4% | -9.4% | -33.5% | -39.3% | -36.3% | -34.3% | -36.8% | — | — |
| ROA | -8.3% | -8.3% | -29.4% | -33.5% | -32.6% | -31.0% | -20.6% | -49.0% | -299.7% |
| ROIC | -10.0% | -10.0% | -37.0% | -61.6% | -83.6% | -303.2% | — | — | — |
| ROCE | -9.0% | -9.0% | -37.6% | -41.5% | -36.3% | -32.9% | -21.8% | -40.3% | — |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.02 | 0.02 | 0.00 | 0.02 | 0.02 | 0.03 | 0.00 | — | — |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | -1.28 | -0.15 | -0.35 | -0.57 | -0.81 | -1.05 | — | — |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — | — |
| Debt / FCF | — | — | — | — | — | — | — | -39.75 | — |
| Interest Coverage | — | — | — | — | — | — | -211.22 | -2.35 | -14.62 |
Net cash position: cash ($270M) exceeds total debt ($4M)
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 6.53 | 6.53 | 15.73 | 7.58 | 12.00 | 13.86 | 22.74 | 9.35 | 0.70 |
| Quick Ratio | 6.53 | 6.53 | 15.73 | 7.58 | 12.00 | 13.86 | 22.74 | 9.35 | 0.70 |
| Cash Ratio | 6.46 | 6.46 | 15.32 | 7.38 | 11.77 | 13.67 | 22.50 | 9.24 | 0.67 |
| Asset Turnover | — | 0.07 | 0.01 | 0.02 | 0.01 | 0.02 | 0.02 | 0.02 | 0.10 |
| Inventory Turnover | — | — | — | — | — | — | — | — | — |
| Days Sales Outstanding | — | — | 945.31 | 329.23 | 153.34 | 35.22 | 64.54 | — | — |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | — | — | — | — | — | — |
| FCF Yield | — | — | — | — | — | — | — | — | — |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — | — |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — | — |
| Shares Outstanding | — | $17M | $112M | $73M | $52M | $41M | $22M | $38M | $21M |
Clinical trial execution failure
According to recent market data, Atrium Therapeutics trades at a price-to-sales ratio of 12.12, a valuation that appears to reflect investor expectations for the AOC platform's long-term clinical success rather than any near-term earnings potential, as the company currently lacks commercial product revenue to support traditional multiples.
The absence of a meaningful P/E ratio, coupled with a P/B of 1.09, suggests that the market is pricing the firm as a speculative R&D engine. Investors should monitor whether this platform premium holds if clinical readouts fail to demonstrate clear superiority over existing therapeutic modalities.
Based on reported figures, the company's ROIC has consistently trended in negative territory, reaching -31.4% in 2025Q3, which indicates that the firm is currently destroying invested capital as it prioritizes aggressive clinical development over the achievement of positive returns on its research expenditures.
The persistent negative ROIC is a structural byproduct of the pre-commercial biotech model where massive R&D outlays are required before any revenue-generating assets reach the market. This trend warrants further investigation into whether the current capital allocation strategy will eventually yield a positive return once the AOC platform matures.
As reported in financial statements, the company's asset turnover ratio remains negligible at 0.02, highlighting the firm's reliance on non-recurring collaboration milestones rather than operational efficiency to drive its financial performance, which complicates the assessment of its underlying working capital management and long-term asset utilization.
The extreme fluctuations in DSO and DPO metrics suggest that the company's cash conversion cycle is dictated by the timing of partner payments rather than internal operational processes. Investors should be cautious of interpreting these ratios as indicators of operational health, as they are heavily skewed by the lumpy nature of milestone-based revenue recognition.
As evidenced by the most recent quarterly data, the company maintains a current ratio of 13.04, which appears robust on the surface but must be interpreted in the context of a high-burn clinical development model that necessitates constant, significant capital outflows to maintain its current research pipeline.
While the current liquidity position provides a temporary buffer, the rapid consumption of cash to fund clinical trials suggests that the firm remains vulnerable to equity market volatility. The high current ratio is less a sign of operational strength and more a reflection of the capital raised to sustain future R&D activities.
The P/S ratio is frequently misapplied to Atrium Therapeutics, as it obscures the fact that the company's revenue is derived from non-recurring collaboration milestones rather than sustainable product sales, making it an unreliable metric for assessing the firm's true commercial viability or long-term growth trajectory.
Analysts should instead focus on cash runway duration and clinical milestone progress as more accurate indicators of value creation. Relying on P/S multiples in a pre-commercial biotech context may lead to an overestimation of the company's current market position and a misunderstanding of its fundamental financial risks.
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Quick answers to the most common questions about buying RNA stock.
Atrium Therapeutics, Inc.'s current P/E ratio is -2.9x. This places it at the 50th percentile of its historical range.
Atrium Therapeutics, Inc.'s return on equity (ROE) is -9.4%. The historical average is -31.6%.
Based on historical data, Atrium Therapeutics, Inc. is trading at a P/E of -2.9x. This is at the 50th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.
Atrium Therapeutics, Inc. has 100.0% gross margin and -412.6% operating margin.