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PVLAPalvella Therapeutics, Inc.
$145.70$1.7B
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PVLA logoPalvella Therapeutics, Inc.(PVLA)Earnings, Financials & Key Ratios

PVLA•NASDAQ
$145.70
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Rare Disease Biopharma
AboutPalvella Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel therapies to treat patients serious and rare genetic skin diseases. Its lead product candidate is QTORIN 3.9% rapamycin anhydrous gel (QTORIN rapamycin) that is in Phase 3 clinical trial for the treatment of microcystic lymphatic malformations, as well as in Phase 2 clinical trial to treat cutaneous venous malformations. It also develops QTORIN rapamycin for the treatment of other mTOR-driven skin diseases. The company is based in Wayne, Pennsylvania.Show more
  • Revenue$0
  • EBITDA-$36M-173.7%
  • Net Income-$42M-139.3%
  • EPS (Diluted)-3.71+52.6%
  • ROE-92.1%-55.1%

PVLA Price & Volume

Palvella Therapeutics, Inc. (PVLA) stock price & volume — 10-year historical chart

Loading chart...

Clinical Development Costs Drive Persistent Cash Burn

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Contracting
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Clinical trial funding dependency

Key Thesis Takeaways

  • Palvella Therapeutics operates as a pre-revenue clinical-stage biotechnology firm, with its valuation entirely tethered to the successful advancement of its QTORIN gel platform.
  • The company faces significant financial pressure as R&D expenses have escalated to $9.3 million in 2026Q1, leading to a widening operating loss of $14.9 million.
  • Investors should monitor the company's ability to manage its $206.4 million cash position against the backdrop of cumulative retained earnings losses of $151.2 million, which underscores the high-risk nature of its development-heavy business model.

Verdict Logic

the company's reliance on capital markets is evidenced by a $10.9 million quarterly free cash flow burn and the absence of any revenue-generating activities to offset its $15.8 million net loss in 2026Q1.

PVLA Growth Metrics

Palvella Therapeutics, Inc. (PVLA) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-161.61%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM58.01%

Return on Capital

10 Years-68.9%
5 Years-74.49%
3 Years-81.9%
Last Year-62.06%

PVLA Recent Earnings

Palvella Therapeutics, Inc. (PVLA) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 6/12 qtrs (50%)●Beat Revenue 2/12 qtrs (67%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$1.20-26.3%
$0.95
Rev
—
—
Q2 2026
Mar 31, 2026
Metric
Actual
Est
EPS
$1.08-18.5%
$0.91
Rev
—
—
Q4 2025
Nov 11, 2025
Metric
Actual
Est
EPS
$1.03-21.2%
$0.85
Rev
—
—
Q3 2025
Aug 14, 2025
Metric
Actual
Est
EPS
$0.86-10.3%
$0.78
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$1.20vs $0.95-26.3%
—
Q2 2026Mar 31, 2026
$1.08vs $0.91-18.5%
—
Q4 2025Nov 11, 2025
$1.03vs $0.85-21.2%
—
Q3 2025Aug 14, 2025
$0.86vs $0.78-10.3%
—
Based on last 12 quarters of dataView full earnings history →

Latest PVLA News

Recent stock market news and headlines for Palvella Therapeutics, Inc. (PVLA)

GlobeNewsWire·Jun 30, 2026
Palvella Therapeutics Appoints Accomplished Rare Disease Biotech Executive and Commercial Leader Matt Pauls, J.D., M.B.A., to Board of Directors

Brings more than 25 years of experience advancing and commercializing high-impact therapies for serious diseases, including those with limited or no approved treatment options

GlobeNewsWire·Jun 29, 2026
Palvella Therapeutics Submits First Module of Rolling New Drug Application to FDA for QTORIN™ Rapamycin for the Treatment of Microcystic Lymphatic Malformations

FDA's rolling review process is intended to facilitate expedited review, enabling FDA to begin evaluating completed modules of the NDA before the full application is submitted

The Motley Fool·Jun 27, 2026
What to Know About This $476,000 Palvella Therapeutics Insider Sale After a 620% Stock Rally

4,302 common shares were exercised and sold on June 17, 2026, for $476,000 at a weighted average price of around $110.73 per share. This was a derivative transaction involving the exercise and immediate sale of options.

GlobeNewsWire·Jun 22, 2026
FDA Grants Rolling Review of Palvella's QTORIN™ Rapamycin NDA for Microcystic Lymphatic Malformations

FDA's rolling review process is intended to facilitate expedited review, enabling FDA to begin evaluating completed sections of the NDA before the full application is submitted

Peers Comparison

Key metrics vs top competitors for Palvella Therapeutics, Inc. (PVLA)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
PVLA logoPVLAPalvella Therapeutics, Inc.Current
$145.70$1.72B-39.27——-92.1%—
NKTR logoNKTRNektar Therapeutics
$74.90$1.46B-7.70-43.89%-284.18%-87%—
PRAX logoPRAXPraxis Precision Medicines, Inc.
$323.95$9.36B-24.03-100%—-43.02%—
IMVT logoIMVTImmunovant, Inc.
$40.09$8.23B-14.47——-68.16%—
ARDX logoARDXArdelyx, Inc.
$5.38$1.32B-20.6922.09%-13.58%-38.11%—
RCKT logoRCKTRocket Pharmaceuticals, Inc.
$4.07$444.42M-2.02——-70.79%—

Compare PVLA vs Peers

Palvella Therapeutics, Inc. (PVLA) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs NKTR

Most directly comparable listed peer for PVLA.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare PVLA against a more recognizable public peer.

Peer Set

Compare Top 5

vs NKTR, PRAX, IMVT, ARDX

PVLA SEC Filings & Documents

Palvella Therapeutics, Inc. (PVLA) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 20, 2026·SEC

Material company update

May 15, 2026·SEC

Material company update

May 13, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 31, 2026·SEC

FY 2025

Mar 31, 2025·SEC

FY 2024

Mar 29, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 12, 2025·SEC

FY 2025

Aug 14, 2025·SEC

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PVLA Frequently Asked Questions

Palvella Therapeutics, Inc. (PVLA) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
Is PVLA profitable?

Palvella Therapeutics, Inc. (PVLA) reported a net loss of $49.3M for fiscal year 2025.

Dividend & Returns
What is PVLA's return on equity?

Palvella Therapeutics, Inc. (PVLA) has a return on equity (ROE) of -92.1%. Negative ROE indicates the company is unprofitable.

What is Palvella Therapeutics, Inc.'s free cash flow?

Palvella Therapeutics, Inc. (PVLA) had negative free cash flow of $29.1M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in PVLA back in 2020?

Total return calculator · dividends reinvested · 6+ years of data

See returns →