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PBYIPuma Biotechnology, Inc.
$8.22$418M
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Puma Biotechnology, Inc. (PBYI) Financial Ratios

Latest Ratios: P/E Ratio 13.5x · EV/EBITDA 8.7x · ROE 28.0%. (2007–2025 historical series)

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly

PBYI Valuation Multiples

Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Market Cap$418M$301M$150M$206M$190M$124M$406M$339M$772M$3.7B$1.0B
Enterprise Value$417M$300M$155M$233M$228M$177M$442M$399M$816M$3.6B$828M
P/E Ratio →13.489.754.929.62208.37——————
P/S Ratio1.831.320.650.870.830.491.801.253.08132.64—
P/B Ratio3.192.311.633.858.80——19.4322.5168.934.87
P/FCF10.037.223.8514.33—5.98—15.37———
P/OCF10.017.213.857.62—5.98507.5615.16———

P/E links to full P/E history page with 30-year chart

PBYI EV Ratios

Enterprise-value multiples — capital-structure-neutral measures of total business value

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
EV / Revenue—1.310.670.991.000.701.961.473.25131.44—
EV / EBITDA8.656.233.645.276.8014.06—————
EV / EBIT11.197.084.236.4718.93——————
EV / FCF—7.203.9816.20—8.57—18.10———

PBYI Profitability

Margins and return-on-capital ratios measuring operating efficiency

Margins

Full margin charts and quarterly trend are on the Earnings History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Gross Margin74.5%74.5%72.1%73.4%75.8%74.8%82.5%86.5%86.2%79.8%—
Operating Margin16.3%16.3%13.4%13.9%10.4%0.5%-13.5%-27.8%-37.7%-1055.6%—
Net Profit Margin13.6%13.6%13.1%9.2%0.0%-11.5%-26.7%-27.8%-45.3%-1054.2%—

Return on Capital

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
ROE28.0%28.0%41.6%57.5%0.0%—-1042.3%-292.0%-259.3%-222.0%-132.8%
ROA14.5%14.5%13.6%9.5%0.0%-12.4%-25.0%-30.6%-53.5%-139.6%-112.1%
ROIC24.7%24.7%26.2%35.0%32.1%2.4%-42.5%-72.9%-145.1%-1239.8%-218.7%
ROCE29.6%29.6%24.9%23.7%18.1%1.0%-22.2%-45.0%-63.3%-181.3%-130.9%

PBYI Leverage & Debt

Solvency and debt-coverage ratios — lower is generally safer

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Debt / Equity0.220.220.802.095.29——6.884.430.91—
Debt / EBITDA0.590.591.742.523.419.26—————
Net Debt / Equity—-0.010.050.501.76——3.451.27-0.62-0.93
Net Debt / EBITDA-0.02-0.020.110.611.134.25—————
Debt / FCF—-0.030.131.87—2.59—2.73———
Interest Coverage6.406.402.942.701.04-1.25-3.26-4.03-9.33-404.49-288.72

Net cash position: cash ($30M) exceeds total debt ($29M)

PBYI Liquidity & Efficiency

Short-term solvency ratios and asset-utilisation metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Current Ratio2.002.001.541.571.731.281.281.833.021.826.31
Quick Ratio1.931.931.451.501.671.211.251.802.991.796.31
Cash Ratio1.201.201.050.971.050.750.821.231.621.405.19
Asset Turnover—1.061.081.021.031.120.921.160.970.17—
Inventory Turnover10.5510.557.388.8512.178.9611.4011.6113.182.76—
Days Sales Outstanding—85.7550.7075.1167.6646.9041.4238.7431.92127.42—

PBYI Shareholder Yields

Earnings, FCF, buyback, and dividend yields — total returns to shareholders

Dividends

Full dividend history and growth charts are on the Dividend History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Dividend Yield———————————
Payout Ratio———————————

Total Shareholder Return Metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Earnings Yield7.4%10.3%20.3%10.4%0.5%——————
FCF Yield10.0%13.8%26.0%7.0%—16.7%—6.5%———
Buyback Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%
Total Shareholder Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%
Shares Outstanding—$51M$49M$48M$45M$41M$40M$39M$38M$37M$33M

Key Metrics

Growth RegimeContracting
ProfitabilityStrained
Balance SheetVulnerable
Cash FlowMixed
Top Statement Risk

Single-asset commercial stagnation

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2026Q1)

Market Pricing Reflects Terminal Uncertainty

Based on current market data, PBYI trades at a P/S of 1.81 and a forward EV/EBITDA of 4.03, suggesting that investors are pricing the company as a value-oriented, single-asset entity rather than a growth-stage biotech, reflecting significant skepticism regarding the long-term durability of Nerlynx revenue streams.

The forward P/E of 27.97 relative to the TTM P/E of 13.30 implies that the market anticipates a sharp contraction in earnings, likely driven by the expiration of patent exclusivity or competitive erosion. This valuation discount compared to peers with broader pipelines suggests that the market is assigning little to no terminal value to the company's current clinical-stage assets.

Capital Efficiency Deteriorating Amid Stagnation

As reported in recent financial statements, PBYI's ROIC has experienced significant volatility, swinging from a peak of 19.5% in 2024Q3 to a negative 2.4% in 2026Q1, indicating that the company is struggling to generate sustainable returns on its invested capital as commercial performance faces headwinds.

The sharp decline in ROIC suggests that the company's core business model is failing to compound value, likely due to the high fixed-cost structure required to support a single-product commercial footprint. Investors should monitor whether management can pivot toward more efficient capital allocation, as current trends indicate a decay in the firm's ability to generate economic profit.

Working Capital Volatility Obscures Efficiency

According to quarterly data, the company's asset turnover has remained consistently low, hovering around 0.22 to 0.38, which, when combined with a fluctuating cash conversion cycle, suggests that PBYI lacks the operational leverage to optimize its working capital in the face of declining end-user demand.

The variability in DSO, which reached 80 days in 2026Q1, indicates potential challenges in collecting receivables, which may be exacerbated by the company's reliance on a limited number of specialty pharmacy partners. This inefficiency in the cash conversion cycle warrants further investigation, as it directly impacts the firm's ability to maintain liquidity without external financing.

Deleveraging Masks Underlying Liquidity Risks

Based on reported figures, PBYI has aggressively reduced its debt-to-equity ratio from 2.17 in 2024Q1 to 0.12 in 2026Q1, a move that appears to be a defensive reaction to the company's narrowing cash runway and the inherent risks of a single-asset commercial model.

While the reduction in debt improves the balance sheet's solvency profile, it does not address the fundamental issue of revenue stagnation. The interest coverage ratio, which turned negative in 2026Q1, suggests that the company's ability to service even minimal debt obligations is becoming increasingly precarious as operating margins compress.

Misapplication of Standard P/E Multiples

The P/E ratio is frequently misapplied to PBYI, as it fails to account for the lumpy nature of milestone payments and the high non-cash expenses that distort net income, thereby providing a misleading picture of the company's true cash-generating capacity and long-term commercial viability.

Analysts should instead focus on EV/Revenue or adjusted FCF metrics, which better capture the underlying health of the Nerlynx franchise by stripping out accounting noise. Relying on P/E in a biotech context often obscures the reality that the company's earnings are highly sensitive to R&D spending cycles and royalty obligations, which are not captured by standard valuation multiples.

Download Financial Ratios Data

Includes 30+ ratios · 19 years · Updated daily

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PBYI — Frequently Asked Questions

Quick answers to the most common questions about buying PBYI stock.

What is Puma Biotechnology, Inc.'s P/E ratio?

Puma Biotechnology, Inc.'s current P/E ratio is 13.5x. The historical average is 8.1x. This places it at the 100th percentile of its historical range.

What is Puma Biotechnology, Inc.'s EV/EBITDA?

Puma Biotechnology, Inc.'s current EV/EBITDA is 8.7x. This enterprise value multiple compares the company's total value (equity + debt - cash) to its EBITDA. The historical average is 7.2x.

What is Puma Biotechnology, Inc.'s ROE?

Puma Biotechnology, Inc.'s return on equity (ROE) is 28.0%. This is above the typical threshold of 15-20% considered good for most companies. The historical average is -88.6%.

Is PBYI stock overvalued?

Based on historical data, Puma Biotechnology, Inc. is trading at a P/E of 13.5x. This is at the 100th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.

What are Puma Biotechnology, Inc.'s profit margins?

Puma Biotechnology, Inc. has 74.5% gross margin and 16.3% operating margin. Operating margin between 10-20% is typical for established companies.

How much debt does Puma Biotechnology, Inc. have?

Puma Biotechnology, Inc.'s Debt/EBITDA ratio is 0.6x, indicating low leverage. A ratio below 2x is generally considered financially healthy.