Latest Ratios: P/E Ratio -7.7x · EV/EBITDA N/A · ROE -217.9%. (1996–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $1.5B | $713M | $191M | $107M | $423M | $2.5B | $3.0B | $3.8B | $5.9B | $9.3B | $1.7B |
| Enterprise Value | $1.6B | $847M | $250M | $190M | $466M | $2.6B | $3.0B | $4.1B | $6.0B | $9.6B | $1.9B |
| P/E Ratio → | -7.70 | — | — | — | — | — | — | — | 8.70 | — | — |
| P/S Ratio | 26.50 | 12.91 | 1.94 | 1.19 | 4.59 | 24.30 | 19.85 | 32.96 | 4.96 | 30.27 | 10.35 |
| P/B Ratio | 14.07 | 7.94 | 3.15 | 0.82 | 1.15 | 3.64 | 2.82 | 2.69 | 3.45 | 106.04 | 19.44 |
| P/FCF | — | — | — | — | — | — | — | — | 8.41 | — | — |
| P/OCF | — | — | — | — | — | — | — | — | 8.24 | — | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 15.34 | 2.54 | 2.11 | 5.06 | 25.46 | 19.54 | 35.68 | 5.00 | 31.05 | 11.50 |
| EV / EBITDA | — | — | — | — | — | — | — | — | 8.57 | — | — |
| EV / EBIT | — | — | — | — | — | — | — | — | 8.23 | — | — |
| EV / FCF | — | — | — | — | — | — | — | — | 8.48 | — | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 100.0% | 100.0% | 68.8% | 59.3% | 76.5% | 75.6% | 87.3% | 81.4% | 98.0% | 90.1% | 81.7% |
| Operating Margin | -236.8% | -236.8% | -106.9% | -152.5% | -261.0% | -437.8% | -248.5% | -383.9% | 57.6% | -19.4% | -68.2% |
| Net Profit Margin | -297.1% | -297.1% | -120.9% | -306.3% | -400.0% | -514.0% | -290.6% | -384.5% | 57.1% | -31.4% | -92.8% |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -217.9% | -217.9% | -124.1% | -110.9% | -70.4% | -59.6% | -35.8% | -28.2% | 75.5% | -109.9% | -324.7% |
| ROA | -56.2% | -56.2% | -33.9% | -49.8% | -40.3% | -39.4% | -25.3% | -21.4% | 51.2% | -17.9% | -28.7% |
| ROIC | -57.2% | -57.2% | -47.5% | -33.1% | -29.8% | -36.6% | -20.8% | -18.9% | 49.2% | -14.8% | -35.6% |
| ROCE | -55.7% | -55.7% | -35.7% | -27.8% | -28.7% | -36.3% | -24.9% | -23.8% | 54.6% | -12.6% | -24.1% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 1.66 | 1.66 | 1.69 | 0.90 | 0.36 | 0.21 | 0.14 | 0.29 | 0.14 | 2.79 | 2.82 |
| Debt / EBITDA | — | — | — | — | — | — | — | — | 0.35 | — | — |
| Net Debt / Equity | — | 1.49 | 0.96 | 0.63 | 0.12 | 0.17 | -0.05 | 0.22 | 0.03 | 2.74 | 2.14 |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — | 0.07 | — | — |
| Debt / FCF | — | — | — | — | — | — | — | — | 0.07 | — | — |
| Interest Coverage | -4.99 | -4.99 | -3.24 | -9.90 | -11.62 | -10.06 | -10.96 | -8.49 | 16.96 | -1.35 | -2.62 |
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 4.97 | 4.97 | 4.26 | 6.45 | 8.00 | 9.34 | 9.83 | 4.02 | 17.53 | 5.82 | 5.90 |
| Quick Ratio | 4.97 | 4.97 | 4.26 | 6.14 | 7.72 | 9.15 | 9.70 | 3.98 | 17.39 | 5.63 | 5.75 |
| Cash Ratio | 4.59 | 4.59 | 4.16 | 5.92 | 7.40 | 8.61 | 9.17 | 3.74 | 16.28 | 5.27 | 5.39 |
| Asset Turnover | — | 0.20 | 0.32 | 0.23 | 0.13 | 0.09 | 0.10 | 0.06 | 0.55 | 0.60 | 0.29 |
| Inventory Turnover | — | — | — | 2.28 | 1.13 | 1.58 | 1.27 | 1.69 | 2.14 | 2.85 | 2.72 |
| Days Sales Outstanding | — | 11.76 | 5.97 | 9.12 | 33.32 | 80.56 | 92.83 | 117.20 | 13.22 | 5.95 | 34.59 |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | — | — | — | — | — | 11.5% | — | — |
| FCF Yield | — | — | — | — | — | — | — | — | 11.9% | — | — |
| Buyback Yield | 0.0% | 0.0% | 1.6% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Total Shareholder Yield | 0.0% | 0.0% | 1.6% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Shares Outstanding | — | $17M | $14M | $13M | $12M | $12M | $12M | $12M | $12M | $10M | $9M |
Imminent liquidity and solvency
Based on reported financial data, Nektar's P/S ratio of 22.52 appears disconnected from its contracting revenue base, suggesting that the market is pricing the firm as a distressed asset rather than a growth-oriented platform, with valuation multiples heavily skewed by the absence of positive earnings.
The lack of meaningful P/E or EV/EBITDA multiples underscores the market's focus on binary clinical outcomes rather than fundamental cash generation. Investors should monitor whether the current premium over book value is justified by the remaining immunology pipeline or if it represents a speculative floor that may collapse without further partnership validation.
As reported in recent financial statements, Nektar's ROIC has trended deeply into negative territory, reaching -7.1% in 2026Q1, which indicates that the company is currently destroying shareholder value by deploying capital into research programs that have yet to yield a sustainable return on invested capital.
The persistent negative ROIC highlights the structural challenge of a biotech model that consumes significant capital without achieving commercial scale. This trend suggests that management's capital allocation strategy has struggled to balance the high costs of clinical development against the diminishing returns of its legacy licensing portfolio.
According to recent SEC filings, Nektar's asset turnover ratio remains extremely low at 0.02, illustrating the company's inability to generate meaningful revenue from its asset base and highlighting the inefficiency inherent in its current project-based, milestone-dependent business model compared to more established industry peers.
The erratic nature of the cash conversion cycle, compounded by high days sales outstanding, suggests that the company lacks leverage in its partnership agreements. This inefficiency warrants further investigation, as it indicates that the firm's operational structure is not optimized for the timely conversion of research milestones into liquid cash.
Based on the company's reported figures, the current ratio of 10.21 in 2026Q1 masks a precarious cash position, as the firm's liquidity is increasingly tied to non-liquid assets rather than the cash required to sustain its high-burn R&D operations through the next clinical inflection point.
While the current ratio appears high, it is misleading in the context of a biotech firm with limited cash reserves and significant ongoing clinical trial commitments. Investors should monitor the company's ability to secure additional financing, as the current liquidity profile appears insufficient to support long-term operational continuity.
As evidenced by the 100% gross margin reported in several quarters, this metric is frequently misapplied to Nektar's business model, as it obscures the massive, sunk R&D costs that function as the true cost of goods sold for a platform-based biotechnology company.
Relying on gross margin to assess profitability is fundamentally flawed for this entity, as it ignores the recurring research expenses required to maintain the intellectual property. Analysts should instead focus on the operating margin and cash burn rate to gain a more accurate understanding of the company's true earning power.
Includes 30+ ratios · 30 years · Updated daily
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Quick answers to the most common questions about buying NKTR stock.
Nektar Therapeutics's current P/E ratio is -7.7x. The historical average is 8.7x.
Nektar Therapeutics's return on equity (ROE) is -217.9%. The historical average is -81.5%.
Based on historical data, Nektar Therapeutics is trading at a P/E of -7.7x. Compare with industry peers and growth rates for a complete picture.
Nektar Therapeutics has 100.0% gross margin and -236.8% operating margin.