Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in KRYS held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4.4M | $1.13B | +0.6% | 14.837% | 0.06% |
| 2 | BlackRock, Inc. | 3.9M | $1.02B | +0.1% | 13.367% | 0.02% |
| 3 | Avoro Capital Advisors LLC | 2.9M | $746.3M | 0.0% | 9.800% | 7.63% |
| 4 | VANGUARD PORTFOLIO MANAGEMENT LLC | 1.5M | $376.3M | — | 4.941% | 0.02% |
| 5 | STATE STREET CORP | 1.3M | $339.5M | -2.1% | 4.459% | 0.01% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 1.2M | $301.0M | — | 3.953% | 0.01% |
| 7 | Soleus Capital Management, L.P. | 1.2M | $297.9M | +22.5% | 3.911% | 12.06% |
| 8 | Capital World Investors | 825K | $213.0M | +1.9% | 2.798% | 0.03% |
| 9 | Redmile Group, LLC | 674K | $174.0M | -0.6% | 2.285% | 11.52% |
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 644K | $166.4M | +5.3% | 2.184% | 0.01% |
| 11 | Hood River Capital Management LLC | 620K | $160.1M | +1.0% | 2.102% | 1.60% |
| 12 | Bellevue Group AG | 482K | $124.5M | +17.4% | 1.634% | 2.96% |
| 13 | Frazier Life Sciences Management, L.P. | 481K | $124.3M | -1.5% | 1.633% | 3.20% |
| 14 | DIMENSIONAL FUND ADVISORS LP | 469K | $121.1M | -4.9% | 1.591% | 0.03% |
| 15 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 407K | $105.2M | +8.2% | 1.381% | 0.35% |
| 16 | FIRST TRUST ADVISORS LP | 351K | $90.5M | +42.9% | 1.189% | 0.06% |
| 17 | JANUS HENDERSON GROUP PLC | 267K | $68.9M | +21.5% | 0.904% | 0.03% |
| 18 | BANK OF AMERICA CORP /DE/ | 261K | $67.3M | +36.6% | 0.884% | 0.00% |
| 19 | NORTHERN TRUST CORP | 252K | $65.2M | +2.0% | 0.856% | 0.01% |
| 20 | Invesco Ltd. | 251K | $64.9M | +318.9% | 0.853% | 0.01% |
| 21 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 242K | $62.5M | -0.3% | 0.821% | 0.01% |
| 22 | GOLDMAN SACHS GROUP INC | 215K | $55.5M | -26.8% | 0.729% | 0.01% |
| 23 | MORGAN STANLEY | 209K | $54.0M | -5.6% | 0.709% | 0.00% |
| 24 | BRAIDWELL LP | 182K | $47.1M | -9.7% | 0.619% | 1.57% |
| 25 | FRANKLIN RESOURCES INC | 179K | $46.3M | +42.6% | 0.608% | 0.01% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in KRYS — a direct measure of their conviction.
Filings activity in KRYS during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 356 | +6.9% | 75.91% | +3.25 pp | $7.12B | +4.5% |
| Q4 2025 | 333 | +19% | 72.66% | +20.87 pp | $6.81B | +40% |
| Q3 2025 | 280 | +2.9% | 51.79% | +11.64 pp | $4.86B | +29% |
| Q2 2025 | 272 | 6.8% | 40.15% | 10.08 pp | $3.76B | 20% |
| Q1 2025 | 292 | +13% | 50.23% | +5.56 pp | $4.71B | +12% |
| Q4 2024 | 259 | 5.8% | 44.67% | 8.15 pp | $4.19B | 15% |
| Q3 2024 | 275 | +14% | 52.82% | 0.28 pp | $4.95B | 0.5% |
| Q2 2024 | 241 | — | 53.10% | — | $4.98B | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying KRYS stock.
Based on Q1 2026 13F filings, institutional ownership of Krystal Biotech, Inc. stands at 75.9%, held across 356 reporting institutions.
FMR LLC is the largest reported institutional holder of KRYS, with approximately 4,373,987 shares worth $1.13B as of Q1 2026.
No marquee "smart money" managers (Berkshire, Burry, ARK, Tiger Global, Pershing Square, Baupost, etc.) currently appear among the top 25 institutional holders of KRYS.
Our composite Smart Money Score for KRYS is 50 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
73 institutions opened new positions in KRYS during Q1 2026, while 50 fully exited. 210 added to existing positions and 69 trimmed.
KRYS institutional ownership rose by 3.25 percentage points quarter-over-quarter, with a net change of +23 holders.
The top 10 institutions account for 66.9% of all reported 13F value in KRYS, and the top 25 account for 84.6%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Krystal Biotech, Inc. (KRYS) Institutional Ownership