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HOWLWerewolf Therapeutics, Inc.
$0.34$17M
Overview & Verdict
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HOWL logoWerewolf Therapeutics, Inc.(HOWL)Earnings, Financials & Key Ratios

HOWL•NASDAQ
$0.34
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutWerewolf Therapeutics, Inc., a biopharmaceutical company, develops therapeutics engineered to stimulate the body's immune system for the treatment of cancer. The company, through its proprietary PREDATOR platform, designs conditionally activated molecules that stimulate adaptive and innate immunity for addressing the limitations of conventional proinflammatory immune therapies. Its lead product candidates are WTX-124, a conditionally activated Interleukin-2 INDUKINE molecule for the treatment of advanced solid tumors; and WTX-330, a conditionally activated Interleukin-12 INDUKINE molecule for the treatment of relapsed or refractory advanced or metastatic solid tumors or lymphoma. The company is also developing WTX-613, a conditionally activated interferon alpha INDUKINE molecule for the treatment of solid tumors and hematologic malignancies. Werewolf Therapeutics, Inc. was incorporated in 2017 and is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$0-100.0%
  • EBITDA-$59M+17.7%
  • Net Income-$61M+13.7%
  • EPS (Diluted)-1.33+18.4%
  • ROE-123.88%-62.3%

HOWL Price & Volume

Werewolf Therapeutics, Inc. (HOWL) stock price & volume — 10-year historical chart

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Clinical Development Costs Outpace Capital Reserves

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Contracting
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Clinical Trial Funding Gap

Key Thesis Takeaways

  • Werewolf Therapeutics remains a high-risk, pre-commercial biotechnology entity whose valuation is tethered to the success of its INDUKINE platform rather than current revenue generation.
  • The company faces a narrowing operational runway, evidenced by a cash position that has declined to $58 million as of 2026Q1, necessitating potential dilutive financing to sustain ongoing R&D.
  • Investors should monitor the company's ability to secure strategic partnerships, as the current trajectory of persistent quarterly operating losses exceeding $15 million threatens long-term solvency.

Verdict Logic

the company's rapid depletion of assets, which fell from $177.6 million in 2024Q1 to $58.0 million in 2026Q1, indicates a critical funding gap that poses a substantial risk to equity holders.

HOWL Growth Metrics

Werewolf Therapeutics, Inc. (HOWL) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-100%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM22.3%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM26.22%

Return on Capital

10 Years-47.61%
5 Years-48.45%
3 Years-55.52%
Last Year-83.69%

Peers Comparison

Key metrics vs top competitors for Werewolf Therapeutics, Inc. (HOWL)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
HOWL logoHOWLWerewolf Therapeutics, Inc.Current
$0.34$16.72M-0.26-100%—-123.88%—
NKTX logoNKTXNkarta, Inc.
$3.38$241.82M-2.40——-30.9%—
IMVT logoIMVTImmunovant, Inc.
$40.09$8.23B-14.47——-68.16%—
AGEN logoAGENAgenus Inc.
$3.50$145.75M-1029.4110.37%52.16%——
CLDX logoCLDXCelldex Therapeutics, Inc.
$39.93$2.66B-10.24-78.63%-34596.22%-50.72%—
TGTX logoTGTXTG Therapeutics, Inc.
$53.52$8.19B19.3287.32%65.95%87.36%—

Compare HOWL vs Peers

Werewolf Therapeutics, Inc. (HOWL) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs NKTX

Most directly comparable listed peer for HOWL.

Scale Benchmark

vs MRK

Larger-name benchmark to compare HOWL against a more recognizable public peer.

Peer Set

Compare Top 5

vs NKTX, IMVT, AGEN, CLDX

HOWL SEC Filings & Documents

Werewolf Therapeutics, Inc. (HOWL) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 7, 2026·SEC

Material company update

Mar 27, 2026·SEC

Material company update

Feb 24, 2026·SEC

10-K Annual Reports

4
FY 2026

Mar 27, 2026·SEC

FY 2025

Mar 11, 2025·SEC

FY 2024

Mar 7, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 14, 2025·SEC

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HOWL Frequently Asked Questions

Werewolf Therapeutics, Inc. (HOWL) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
How fast is Werewolf Therapeutics, Inc. growing?

Werewolf Therapeutics, Inc. (HOWL) saw revenue decline by 100.0% over the past year.

Is HOWL profitable?

Werewolf Therapeutics, Inc. (HOWL) reported a net loss of $56.3M for fiscal year 2025.

Dividend & Returns
What is HOWL's return on equity?

Werewolf Therapeutics, Inc. (HOWL) has a return on equity (ROE) of -123.9%. Negative ROE indicates the company is unprofitable.

What is Werewolf Therapeutics, Inc.'s free cash flow?

Werewolf Therapeutics, Inc. (HOWL) had negative free cash flow of $51.9M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in HOWL back in 2019?

Total return calculator · dividends reinvested · 7+ years of data

See returns →