Latest Ratios: P/E Ratio -53.0x · EV/EBITDA N/A · ROE -16.9%. (2019–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Market Cap | $1.6B | $1.3B | $513M | $290M | $359M | $950M | — | — |
| Enterprise Value | $1.5B | $1.2B | $331M | $208M | $351M | $604M | — | — |
| P/E Ratio → | -53.04 | — | — | — | — | — | — | — |
| P/S Ratio | 12.85 | 10.53 | 6.78 | — | — | — | — | — |
| P/B Ratio | 8.70 | 5.59 | 2.30 | 1.62 | 1.32 | 2.73 | — | — |
| P/FCF | — | — | 13.50 | — | — | — | — | — |
| P/OCF | — | — | 12.21 | — | — | — | — | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 9.80 | 4.38 | — | — | — | — | — |
| EV / EBITDA | — | — | — | — | — | — | — | — |
| EV / EBIT | — | — | — | — | — | — | — | — |
| EV / FCF | — | — | 8.72 | — | — | — | — | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Gross Margin | 93.2% | 93.2% | 89.3% | — | — | — | — | — |
| Operating Margin | -43.8% | -43.8% | -107.3% | — | — | — | — | — |
| Net Profit Margin | -31.2% | -31.2% | -96.1% | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| ROE | -16.9% | -16.9% | -36.2% | -60.1% | -35.1% | -49.5% | — | — |
| ROA | -8.7% | -8.7% | -19.6% | -41.9% | -30.6% | -35.6% | -118.7% | -72.3% |
| ROIC | -44.2% | -44.2% | -87.8% | -59.6% | -63.6% | — | — | — |
| ROCE | -16.3% | -16.3% | -30.1% | -49.9% | -33.7% | -39.4% | -208.2% | -117.5% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.17 | 0.17 | 0.19 | 0.26 | 0.17 | — | — | — |
| Debt / EBITDA | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | -0.39 | -0.81 | -0.46 | -0.03 | -1.00 | — | — |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — |
| Debt / FCF | — | — | -4.78 | — | — | — | — | — |
| Interest Coverage | — | — | — | — | -29.86 | — | — | -7739.00 |
Net cash position: cash ($130M) exceeds total debt ($39M)
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Current Ratio | 6.12 | 6.12 | 2.40 | 5.07 | 10.79 | 20.96 | 1.49 | 2.27 |
| Quick Ratio | 6.12 | 6.12 | 2.40 | 5.07 | 10.79 | 20.96 | 1.49 | 2.27 |
| Cash Ratio | 5.87 | 5.87 | 2.37 | 4.99 | 10.28 | 20.80 | 1.42 | 1.40 |
| Asset Turnover | — | 0.28 | 0.17 | — | — | — | — | — |
| Inventory Turnover | — | — | — | — | — | — | — | — |
| Days Sales Outstanding | — | 13.58 | 0.83 | — | — | — | — | — |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 |
|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | — | — | — | — | — |
| FCF Yield | — | — | 7.4% | — | — | — | — | — |
| Buyback Yield | 0.0% | 0.0% | 0.1% | 0.0% | 0.0% | 0.0% | — | — |
| Total Shareholder Yield | 0.0% | 0.0% | 0.1% | 0.0% | 0.0% | 0.0% | — | — |
| Shares Outstanding | — | $83M | $74M | $51M | $47M | $47M | $44M | $44M |
Clinical milestone funding dependency
Based on current market data, GLUE trades at a price-to-sales multiple of 11.74, which appears to reflect investor optimism regarding the QuEEN platform's potential rather than current fundamental performance, especially when compared to the broader biotechnology sector's historical valuation ranges for pre-commercial drug discovery firms.
The elevated P/S ratio suggests that the market is pricing in significant future milestone payments or a potential acquisition premium rather than the company's current, highly volatile revenue stream. Investors should monitor whether this valuation can be sustained if clinical readouts for the GSPT1 program fail to demonstrate the anticipated competitive advantage over legacy PROTAC approaches.
As reported in financial statements, GLUE's ROIC has fluctuated significantly, reaching a negative 13.8% in 2026Q1, which indicates that the company is currently destroying rather than compounding invested capital as it continues to fund high-cost research and development without achieving consistent, profitable commercial scale.
The erratic nature of these returns is primarily driven by the timing of milestone-based licensing revenue, which creates artificial spikes in profitability that do not reflect underlying operational efficiency. Until the company transitions to a model where internal assets generate recurring royalty streams, ROIC will likely remain a poor indicator of long-term value creation.
According to recent SEC filings, GLUE's asset turnover ratio remains extremely low at 0.01, highlighting the company's current status as a research-heavy entity that has yet to deploy significant physical assets toward the commercial production or distribution of therapeutic products.
The lack of meaningful asset turnover is typical for early-stage biotech, but it underscores the risk that the company's infrastructure may be underutilized if the QuEEN platform does not yield successful clinical candidates. The high DSO and DPO figures suggest that working capital management is currently secondary to the primary objective of securing and executing complex, long-term pharmaceutical partnerships.
Based on the 2026Q1 balance sheet, GLUE maintains a current ratio of 9.54, which appears to provide a substantial safety net, yet this figure is heavily distorted by the timing of deferred revenue recognition rather than consistent, self-sustaining cash inflows from core biotechnology operations.
While the current ratio suggests a strong ability to meet short-term obligations, the underlying cash position is vulnerable to the high burn rate required to maintain the QuEEN platform. Investors should be wary of interpreting this liquidity as a sign of operational health, as it is essentially a temporary holding of capital intended for future R&D expenditures.
As evidenced by the reported 93.24% gross margin, this metric is frequently misapplied to GLUE, as it reflects accounting-based licensing revenue rather than the true economic cost of manufacturing and distributing oncology drugs, which will likely be significantly higher upon potential commercialization.
Relying on these high gross margins to forecast future profitability is dangerous, as they obscure the reality that the company has not yet faced the true cost of goods sold associated with a commercial product. Analysts should instead focus on the operating margin and the cash burn rate to better understand the company's actual path toward sustainable, long-term profitability.
Includes 30+ ratios · 7 years · Updated daily
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Quick answers to the most common questions about buying GLUE stock.
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