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GLUEMonte Rosa Therapeutics, Inc.
$24.40$1.6B
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  4. Financial Ratios

Monte Rosa Therapeutics, Inc. (GLUE) Financial Ratios

Latest Ratios: P/E Ratio -53.0x · EV/EBITDA N/A · ROE -16.9%. (2019–2025 historical series)

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly

GLUE Valuation Multiples

Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Market Cap$1.6B$1.3B$513M$290M$359M$950M——
Enterprise Value$1.5B$1.2B$331M$208M$351M$604M——
P/E Ratio →-53.04———————
P/S Ratio12.8510.536.78—————
P/B Ratio8.705.592.301.621.322.73——
P/FCF——13.50—————
P/OCF——12.21—————

P/E links to full P/E history page with 30-year chart

GLUE EV Ratios

Enterprise-value multiples — capital-structure-neutral measures of total business value

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
EV / Revenue—9.804.38—————
EV / EBITDA————————
EV / EBIT————————
EV / FCF——8.72—————

GLUE Profitability

Margins and return-on-capital ratios measuring operating efficiency

Margins

Full margin charts and quarterly trend are on the Earnings History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Gross Margin93.2%93.2%89.3%—————
Operating Margin-43.8%-43.8%-107.3%—————
Net Profit Margin-31.2%-31.2%-96.1%—————

Return on Capital

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
ROE-16.9%-16.9%-36.2%-60.1%-35.1%-49.5%——
ROA-8.7%-8.7%-19.6%-41.9%-30.6%-35.6%-118.7%-72.3%
ROIC-44.2%-44.2%-87.8%-59.6%-63.6%———
ROCE-16.3%-16.3%-30.1%-49.9%-33.7%-39.4%-208.2%-117.5%

GLUE Leverage & Debt

Solvency and debt-coverage ratios — lower is generally safer

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Debt / Equity0.170.170.190.260.17———
Debt / EBITDA————————
Net Debt / Equity—-0.39-0.81-0.46-0.03-1.00——
Net Debt / EBITDA————————
Debt / FCF——-4.78—————
Interest Coverage————-29.86——-7739.00

Net cash position: cash ($130M) exceeds total debt ($39M)

GLUE Liquidity & Efficiency

Short-term solvency ratios and asset-utilisation metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Current Ratio6.126.122.405.0710.7920.961.492.27
Quick Ratio6.126.122.405.0710.7920.961.492.27
Cash Ratio5.875.872.374.9910.2820.801.421.40
Asset Turnover—0.280.17—————
Inventory Turnover————————
Days Sales Outstanding—13.580.83—————

GLUE Shareholder Yields

Earnings, FCF, buyback, and dividend yields — total returns to shareholders

Dividends

Full dividend history and growth charts are on the Dividend History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Dividend Yield————————
Payout Ratio————————

Total Shareholder Return Metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019
Earnings Yield————————
FCF Yield——7.4%—————
Buyback Yield0.0%0.0%0.1%0.0%0.0%0.0%——
Total Shareholder Yield0.0%0.0%0.1%0.0%0.0%0.0%——
Shares Outstanding—$83M$74M$51M$47M$47M$44M$44M

Key Metrics

Growth RegimeDecelerating
ProfitabilityNegative
Balance SheetAdequate
Cash FlowBurning
Top Statement Risk

Clinical milestone funding dependency

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2026Q1)

Premium Pricing Amidst Clinical Uncertainty

Based on current market data, GLUE trades at a price-to-sales multiple of 11.74, which appears to reflect investor optimism regarding the QuEEN platform's potential rather than current fundamental performance, especially when compared to the broader biotechnology sector's historical valuation ranges for pre-commercial drug discovery firms.

The elevated P/S ratio suggests that the market is pricing in significant future milestone payments or a potential acquisition premium rather than the company's current, highly volatile revenue stream. Investors should monitor whether this valuation can be sustained if clinical readouts for the GSPT1 program fail to demonstrate the anticipated competitive advantage over legacy PROTAC approaches.

Capital Compounding Remains Elusive

As reported in financial statements, GLUE's ROIC has fluctuated significantly, reaching a negative 13.8% in 2026Q1, which indicates that the company is currently destroying rather than compounding invested capital as it continues to fund high-cost research and development without achieving consistent, profitable commercial scale.

The erratic nature of these returns is primarily driven by the timing of milestone-based licensing revenue, which creates artificial spikes in profitability that do not reflect underlying operational efficiency. Until the company transitions to a model where internal assets generate recurring royalty streams, ROIC will likely remain a poor indicator of long-term value creation.

Working Capital Volatility Masks Operations

According to recent SEC filings, GLUE's asset turnover ratio remains extremely low at 0.01, highlighting the company's current status as a research-heavy entity that has yet to deploy significant physical assets toward the commercial production or distribution of therapeutic products.

The lack of meaningful asset turnover is typical for early-stage biotech, but it underscores the risk that the company's infrastructure may be underutilized if the QuEEN platform does not yield successful clinical candidates. The high DSO and DPO figures suggest that working capital management is currently secondary to the primary objective of securing and executing complex, long-term pharmaceutical partnerships.

Liquidity Buffer Contingent on Milestones

Based on the 2026Q1 balance sheet, GLUE maintains a current ratio of 9.54, which appears to provide a substantial safety net, yet this figure is heavily distorted by the timing of deferred revenue recognition rather than consistent, self-sustaining cash inflows from core biotechnology operations.

While the current ratio suggests a strong ability to meet short-term obligations, the underlying cash position is vulnerable to the high burn rate required to maintain the QuEEN platform. Investors should be wary of interpreting this liquidity as a sign of operational health, as it is essentially a temporary holding of capital intended for future R&D expenditures.

Gross Margin Misleads Profitability Potential

As evidenced by the reported 93.24% gross margin, this metric is frequently misapplied to GLUE, as it reflects accounting-based licensing revenue rather than the true economic cost of manufacturing and distributing oncology drugs, which will likely be significantly higher upon potential commercialization.

Relying on these high gross margins to forecast future profitability is dangerous, as they obscure the reality that the company has not yet faced the true cost of goods sold associated with a commercial product. Analysts should instead focus on the operating margin and the cash burn rate to better understand the company's actual path toward sustainable, long-term profitability.

Download Financial Ratios Data

Includes 30+ ratios · 7 years · Updated daily

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GLUE — Frequently Asked Questions

Quick answers to the most common questions about buying GLUE stock.

What is Monte Rosa Therapeutics, Inc.'s P/E ratio?

Monte Rosa Therapeutics, Inc.'s current P/E ratio is -53.0x. This places it at the 50th percentile of its historical range.

What is Monte Rosa Therapeutics, Inc.'s ROE?

Monte Rosa Therapeutics, Inc.'s return on equity (ROE) is -16.9%. The historical average is -39.5%.

Is GLUE stock overvalued?

Based on historical data, Monte Rosa Therapeutics, Inc. is trading at a P/E of -53.0x. This is at the 50th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.

What are Monte Rosa Therapeutics, Inc.'s profit margins?

Monte Rosa Therapeutics, Inc. has 93.2% gross margin and -43.8% operating margin.