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GHGuardant Health, Inc.
$167.98$22.3B
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  4. Financial Ratios

Guardant Health, Inc. (GH) Financial Ratios

Latest Ratios: P/E Ratio -50.6x · EV/EBITDA N/A · ROE N/A. (2016–2025 historical series)

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly

GH Valuation Multiples

Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Market Cap$22.3B$12.8B$3.7B$3.0B$2.8B$10.1B$12.6B$7.1B$3.2B——
Enterprise Value$23.6B$14.1B$4.6B$3.2B$4.0B$11.0B$12.6B$7.0B$3.1B——
P/E Ratio →-50.60——————————
P/S Ratio22.6813.045.075.376.1827.1243.8333.0235.26——
P/B Ratio———19.0946.1815.719.278.356.09——
P/FCF———————————
P/OCF———————————

P/E links to full P/E history page with 30-year chart

GH EV Ratios

Enterprise-value multiples — capital-structure-neutral measures of total business value

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
EV / Revenue—14.376.175.768.9129.4843.9032.5433.71——
EV / EBITDA———————————
EV / EBIT———————————
EV / FCF———————————

GH Profitability

Margins and return-on-capital ratios measuring operating efficiency

Margins

Full margin charts and quarterly trend are on the Earnings History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Gross Margin64.5%64.5%60.8%59.7%65.2%67.1%67.7%67.0%52.3%36.6%12.4%
Operating Margin-44.4%-44.4%-60.0%-100.1%-121.1%-110.0%-88.9%-38.4%-102.5%-153.7%-173.7%
Net Profit Margin-42.4%-42.4%-59.0%-85.0%-145.6%-108.6%-88.5%-35.3%-93.8%-167.0%-182.7%

Return on Capital

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
ROE——-4584.5%-438.1%-185.7%-40.6%-23.0%-11.0%-20.4%-42.9%-57.9%
ROA-23.8%-23.8%-26.7%-28.2%-34.3%-18.1%-15.7%-9.8%-18.3%-36.2%-39.6%
ROIC-34.9%-34.9%-63.4%-50.8%-29.0%-21.2%-18.0%-10.9%-22.4%-38.3%-52.1%
ROCE-29.4%-29.4%-31.2%-37.7%-31.8%-19.5%-16.5%-11.5%-21.5%-36.0%-42.9%

GH Leverage & Debt

Solvency and debt-coverage ratios — lower is generally safer

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Debt / Equity———8.5322.752.130.630.05—0.000.21
Debt / EBITDA———————————
Net Debt / Equity———1.3920.401.370.02-0.12-0.27-0.23-0.21
Net Debt / EBITDA———————————
Debt / FCF———————————
Interest Coverage-106.14-106.14-167.57-184.71-252.57-148.19-50.60-58.04-66.33-29.80-14.29

GH Liquidity & Efficiency

Short-term solvency ratios and asset-utilisation metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Current Ratio4.844.844.686.546.175.7228.278.219.9912.387.22
Quick Ratio4.564.564.366.245.905.5727.938.009.8012.017.03
Cash Ratio3.973.973.725.685.234.7926.877.198.9211.286.67
Asset Turnover—0.490.500.320.280.170.130.220.150.150.22
Inventory Turnover4.064.064.083.673.034.014.074.664.734.347.99
Days Sales Outstanding—51.2454.4557.4678.9795.3967.8581.70143.7293.6450.52

GH Shareholder Yields

Earnings, FCF, buyback, and dividend yields — total returns to shareholders

Dividends

Full dividend history and growth charts are on the Dividend History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Dividend Yield———————————
Payout Ratio———————————

Total Shareholder Return Metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Earnings Yield———————————
FCF Yield———————————
Buyback Yield0.1%0.1%0.0%0.0%0.0%0.0%0.0%0.0%0.0%——
Total Shareholder Yield0.1%0.1%0.0%0.0%0.0%0.0%0.0%0.0%0.0%——
Shares Outstanding—$125M$123M$112M$102M$101M$98M$91M$85M$71M$13M

Key Metrics

Growth RegimeAccelerating
ProfitabilityNegative
Balance SheetStrained
Cash FlowBurning
Top Statement Risk

High Cash Burn Rate

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2026Q1)

Premium Pricing Reflects Growth Expectations

Based on recent market data, Guardant Health trades at a price-to-sales multiple of 20.15, a valuation that appears to heavily discount future market share gains in the colorectal cancer screening space rather than current, deeply negative earnings performance relative to its diagnostic peers.

The elevated P/S ratio suggests that investors are pricing in a successful transition to mass-market screening, effectively ignoring the lack of a positive P/E multiple. This valuation implies a high-growth trajectory that may be vulnerable if the Shield test fails to achieve rapid, widespread clinical adoption or if reimbursement rates fall short of expectations.

Capital Intensity Impairs Compounding Potential

As reported in financial statements, the company's ROIC has remained consistently negative, fluctuating between -10.6% and -25.5% over the last ten quarters, indicating that the business is currently destroying rather than compounding capital as it funds its aggressive R&D and commercial expansion.

The persistent negative return on invested capital highlights the structural challenge of scaling a high-fixed-cost laboratory model. Without a clear path to positive operating margins, the company's reliance on external capital to fund operations suggests that current investments are not yet generating the economic returns necessary to justify the ongoing dilution of shareholders.

Working Capital Cycles Remain Volatile

According to recent SEC filings, the cash conversion cycle has shown significant volatility, ranging from 47 to 98 days over the past ten quarters, reflecting the inherent difficulties in managing receivables and inventory during a period of rapid commercial scaling and shifting reimbursement cycles.

The fluctuation in the cash conversion cycle suggests that the company faces ongoing challenges in optimizing its working capital, particularly as it navigates the transition from clinical testing to broader screening. Investors should monitor whether these inefficiencies are temporary operational hurdles or structural features of a business model that must manage complex, multi-payer reimbursement environments.

Liquidity Buffer Faces Sustained Pressure

Based on the provided quarterly data, the current ratio has trended downward from 6.54 in 2023Q4 to 4.68 in 2026Q1, signaling that while the company maintains a sufficient short-term liquidity cushion, its cash runway is being steadily eroded by persistent operating losses and heavy capital requirements.

While the current ratio remains above 4.0, suggesting no immediate solvency crisis, the downward trend warrants close observation as the company continues to burn cash to support its Shield platform. The reliance on liquid assets to cover operating deficits implies that any delay in achieving commercial break-even could necessitate further dilutive financing.

Misapplied Focus on Revenue Growth

Market participants frequently over-rely on top-line revenue growth as a proxy for success, which obscures the underlying cash-burn reality and the significant capital intensity required to maintain the company's laboratory infrastructure and specialized sales force in a highly competitive oncology diagnostics market.

Focusing solely on revenue growth ignores the critical importance of the operating margin and the sustainability of the company's cash-burn rate. A more appropriate metric for this business model would be the unit-level contribution margin, which would better reveal whether the company can eventually achieve profitability as it scales its screening volume.

Download Financial Ratios Data

Includes 30+ ratios · 10 years · Updated daily

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GH — Frequently Asked Questions

Quick answers to the most common questions about buying GH stock.

What is Guardant Health, Inc.'s P/E ratio?

Guardant Health, Inc.'s current P/E ratio is -50.6x. This places it at the 50th percentile of its historical range.

Is GH stock overvalued?

Based on historical data, Guardant Health, Inc. is trading at a P/E of -50.6x. This is at the 50th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.

What are Guardant Health, Inc.'s profit margins?

Guardant Health, Inc. has 64.5% gross margin and -44.4% operating margin.