Latest Ratios: P/E Ratio -50.6x · EV/EBITDA N/A · ROE N/A. (2016–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $22.3B | $12.8B | $3.7B | $3.0B | $2.8B | $10.1B | $12.6B | $7.1B | $3.2B | — | — |
| Enterprise Value | $23.6B | $14.1B | $4.6B | $3.2B | $4.0B | $11.0B | $12.6B | $7.0B | $3.1B | — | — |
| P/E Ratio → | -50.60 | — | — | — | — | — | — | — | — | — | — |
| P/S Ratio | 22.68 | 13.04 | 5.07 | 5.37 | 6.18 | 27.12 | 43.83 | 33.02 | 35.26 | — | — |
| P/B Ratio | — | — | — | 19.09 | 46.18 | 15.71 | 9.27 | 8.35 | 6.09 | — | — |
| P/FCF | — | — | — | — | — | — | — | — | — | — | — |
| P/OCF | — | — | — | — | — | — | — | — | — | — | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 14.37 | 6.17 | 5.76 | 8.91 | 29.48 | 43.90 | 32.54 | 33.71 | — | — |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — | — |
| EV / FCF | — | — | — | — | — | — | — | — | — | — | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 64.5% | 64.5% | 60.8% | 59.7% | 65.2% | 67.1% | 67.7% | 67.0% | 52.3% | 36.6% | 12.4% |
| Operating Margin | -44.4% | -44.4% | -60.0% | -100.1% | -121.1% | -110.0% | -88.9% | -38.4% | -102.5% | -153.7% | -173.7% |
| Net Profit Margin | -42.4% | -42.4% | -59.0% | -85.0% | -145.6% | -108.6% | -88.5% | -35.3% | -93.8% | -167.0% | -182.7% |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | — | — | -4584.5% | -438.1% | -185.7% | -40.6% | -23.0% | -11.0% | -20.4% | -42.9% | -57.9% |
| ROA | -23.8% | -23.8% | -26.7% | -28.2% | -34.3% | -18.1% | -15.7% | -9.8% | -18.3% | -36.2% | -39.6% |
| ROIC | -34.9% | -34.9% | -63.4% | -50.8% | -29.0% | -21.2% | -18.0% | -10.9% | -22.4% | -38.3% | -52.1% |
| ROCE | -29.4% | -29.4% | -31.2% | -37.7% | -31.8% | -19.5% | -16.5% | -11.5% | -21.5% | -36.0% | -42.9% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | — | — | — | 8.53 | 22.75 | 2.13 | 0.63 | 0.05 | — | 0.00 | 0.21 |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | — | — | 1.39 | 20.40 | 1.37 | 0.02 | -0.12 | -0.27 | -0.23 | -0.21 |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — |
| Debt / FCF | — | — | — | — | — | — | — | — | — | — | — |
| Interest Coverage | -106.14 | -106.14 | -167.57 | -184.71 | -252.57 | -148.19 | -50.60 | -58.04 | -66.33 | -29.80 | -14.29 |
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 4.84 | 4.84 | 4.68 | 6.54 | 6.17 | 5.72 | 28.27 | 8.21 | 9.99 | 12.38 | 7.22 |
| Quick Ratio | 4.56 | 4.56 | 4.36 | 6.24 | 5.90 | 5.57 | 27.93 | 8.00 | 9.80 | 12.01 | 7.03 |
| Cash Ratio | 3.97 | 3.97 | 3.72 | 5.68 | 5.23 | 4.79 | 26.87 | 7.19 | 8.92 | 11.28 | 6.67 |
| Asset Turnover | — | 0.49 | 0.50 | 0.32 | 0.28 | 0.17 | 0.13 | 0.22 | 0.15 | 0.15 | 0.22 |
| Inventory Turnover | 4.06 | 4.06 | 4.08 | 3.67 | 3.03 | 4.01 | 4.07 | 4.66 | 4.73 | 4.34 | 7.99 |
| Days Sales Outstanding | — | 51.24 | 54.45 | 57.46 | 78.97 | 95.39 | 67.85 | 81.70 | 143.72 | 93.64 | 50.52 |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | — | — | — | — | — | — | — | — |
| FCF Yield | — | — | — | — | — | — | — | — | — | — | — |
| Buyback Yield | 0.1% | 0.1% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — | — |
| Total Shareholder Yield | 0.1% | 0.1% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — | — |
| Shares Outstanding | — | $125M | $123M | $112M | $102M | $101M | $98M | $91M | $85M | $71M | $13M |
High Cash Burn Rate
Based on recent market data, Guardant Health trades at a price-to-sales multiple of 20.15, a valuation that appears to heavily discount future market share gains in the colorectal cancer screening space rather than current, deeply negative earnings performance relative to its diagnostic peers.
The elevated P/S ratio suggests that investors are pricing in a successful transition to mass-market screening, effectively ignoring the lack of a positive P/E multiple. This valuation implies a high-growth trajectory that may be vulnerable if the Shield test fails to achieve rapid, widespread clinical adoption or if reimbursement rates fall short of expectations.
As reported in financial statements, the company's ROIC has remained consistently negative, fluctuating between -10.6% and -25.5% over the last ten quarters, indicating that the business is currently destroying rather than compounding capital as it funds its aggressive R&D and commercial expansion.
The persistent negative return on invested capital highlights the structural challenge of scaling a high-fixed-cost laboratory model. Without a clear path to positive operating margins, the company's reliance on external capital to fund operations suggests that current investments are not yet generating the economic returns necessary to justify the ongoing dilution of shareholders.
According to recent SEC filings, the cash conversion cycle has shown significant volatility, ranging from 47 to 98 days over the past ten quarters, reflecting the inherent difficulties in managing receivables and inventory during a period of rapid commercial scaling and shifting reimbursement cycles.
The fluctuation in the cash conversion cycle suggests that the company faces ongoing challenges in optimizing its working capital, particularly as it navigates the transition from clinical testing to broader screening. Investors should monitor whether these inefficiencies are temporary operational hurdles or structural features of a business model that must manage complex, multi-payer reimbursement environments.
Based on the provided quarterly data, the current ratio has trended downward from 6.54 in 2023Q4 to 4.68 in 2026Q1, signaling that while the company maintains a sufficient short-term liquidity cushion, its cash runway is being steadily eroded by persistent operating losses and heavy capital requirements.
While the current ratio remains above 4.0, suggesting no immediate solvency crisis, the downward trend warrants close observation as the company continues to burn cash to support its Shield platform. The reliance on liquid assets to cover operating deficits implies that any delay in achieving commercial break-even could necessitate further dilutive financing.
Market participants frequently over-rely on top-line revenue growth as a proxy for success, which obscures the underlying cash-burn reality and the significant capital intensity required to maintain the company's laboratory infrastructure and specialized sales force in a highly competitive oncology diagnostics market.
Focusing solely on revenue growth ignores the critical importance of the operating margin and the sustainability of the company's cash-burn rate. A more appropriate metric for this business model would be the unit-level contribution margin, which would better reveal whether the company can eventually achieve profitability as it scales its screening volume.
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Guardant Health, Inc.'s current P/E ratio is -50.6x. This places it at the 50th percentile of its historical range.
Based on historical data, Guardant Health, Inc. is trading at a P/E of -50.6x. This is at the 50th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.
Guardant Health, Inc. has 64.5% gross margin and -44.4% operating margin.