Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in EWTX held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 15.5M | $488.8M | 0.0% | 14.423% | 10.30% |
| 2 | RA CAPITAL MANAGEMENT, L.P. | 10.4M | $328.5M | 0.0% | 9.692% | 3.48% |
| 3 | Paradigm Biocapital Advisors LP | 7.4M | $232.0M | +12.6% | 6.845% | 4.74% |
| 4 | BAKER BROS. ADVISORS LP | 6.6M | $207.1M | 0.0% | 6.112% | 1.19% |
| 5 | BlackRock, Inc. | 6.5M | $203.9M | -2.4% | 6.016% | 0.00% |
| 6 | JANUS HENDERSON GROUP PLC | 5.9M | $186.3M | +29.5% | 5.498% | 0.09% |
| 7 | Novo Holdings A/S | 5.3M | $168.5M | 0.0% | 4.972% | 13.65% |
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 4.5M | $141.1M | +6.8% | 4.162% | 1.04% |
| 9 | Siren, L.L.C. | 4.4M | $139.6M | -2.2% | 4.118% | 3.87% |
| 10 | PERCEPTIVE ADVISORS LLC | 4.4M | $139.4M | -0.8% | 4.112% | 2.76% |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 3.8M | $119.3M | β | 3.521% | 0.00% |
| 12 | Cormorant Asset Management, LP | 3.3M | $102.7M | -0.8% | 3.030% | 5.16% |
| 13 | BRAIDWELL LP | 2.3M | $73.9M | -54.9% | 2.182% | 2.47% |
| 14 | MORGAN STANLEY | 2.2M | $70.7M | -22.8% | 2.087% | 0.00% |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 1.8M | $56.4M | +2.5% | 1.663% | 0.00% |
| 16 | STATE STREET CORP | 1.7M | $54.1M | -0.0% | 1.596% | 0.00% |
| 17 | MPM Oncology Impact Management LP | 1.7M | $52.3M | +0.3% | 1.544% | 4.04% |
| 18 | Integral Health Asset Management, LLC | 1.6M | $50.4M | +6.7% | 1.487% | 3.11% |
| 19 | Bellevue Group AG | 1.5M | $48.1M | 0.0% | 1.421% | 1.15% |
| 20 | Soleus Capital Management, L.P. | 1.4M | $45.7M | +59.3% | 1.348% | 1.85% |
| 21 | ALLIANCEBERNSTEIN L.P. | 1.7M | $42.7M | +66.2% | 1.601% | 0.01% |
| 22 | BANK OF AMERICA CORP /DE/ | 1.3M | $41.8M | -10.0% | 1.234% | 0.00% |
| 23 | UBS Group AG | 1.3M | $41.3M | -38.1% | 1.219% | 0.01% |
| 24 | DIMENSIONAL FUND ADVISORS LP | 1.2M | $38.4M | +0.5% | 1.134% | 0.01% |
| 25 | AMERICAN CENTURY COMPANIES INC | 1.1M | $36.1M | -3.3% | 1.066% | 0.02% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in EWTX β a direct measure of their conviction.
Filings activity in EWTX during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 209 | +7.2% | 99.28% | +18.42 pp | $3.72B | +23% |
| Q4 2025 | 195 | +14% | 80.86% | +32.47 pp | $3.03B | +67% |
| Q3 2025 | 171 | 3.9% | 48.39% | +7.20 pp | $1.81B | +17% |
| Q2 2025 | 178 | 3.3% | 41.19% | 17.44 pp | $1.54B | 30% |
| Q1 2025 | 184 | 8.0% | 58.63% | 10.98 pp | $2.20B | 16% |
| Q4 2024 | 200 | +16% | 69.61% | 2.51 pp | $2.61B | 3.5% |
| Q3 2024 | 173 | +24% | 72.12% | +24.64 pp | $2.70B | +52% |
| Q2 2024 | 140 | β | 47.48% | β | $1.78B | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying EWTX stock.
Based on Q1 2026 13F filings, institutional ownership of Edgewise Therapeutics, Inc. stands at 99.3%, held across 209 reporting institutions.
ORBIMED ADVISORS LLC is the largest reported institutional holder of EWTX, with approximately 15,518,492 shares worth $0.49B as of Q1 2026.
No marquee "smart money" managers (Berkshire, Burry, ARK, Tiger Global, Pershing Square, Baupost, etc.) currently appear among the top 25 institutional holders of EWTX.
Our composite Smart Money Score for EWTX is 50 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
44 institutions opened new positions in EWTX during Q1 2026, while 30 fully exited. 137 added to existing positions and 27 trimmed.
EWTX institutional ownership rose by 18.42 percentage points quarter-over-quarter, with a net change of +14 holders.
The top 10 institutions account for 60.1% of all reported 13F value in EWTX, and the top 25 account for 83.6%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Edgewise Therapeutics, Inc. (EWTX) Institutional Ownership