Latest Ratios: P/E Ratio -13.1x · EV/EBITDA N/A · ROE N/A. (2002–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $10.5B | $7.6B | $5.3B | $8.1B | $4.1B | $3.5B | $1.3B | $611M | $344M | $403M | $517M |
| Enterprise Value | $10.9B | $8.0B | $6.0B | $8.7B | $4.8B | $3.7B | $1.4B | $711M | $344M | $309M | $478M |
| P/E Ratio → | -13.08 | — | — | — | — | — | — | — | — | — | 31.15 |
| P/S Ratio | 119.71 | 86.68 | 285.13 | 1070.22 | 43.51 | 49.76 | 24.02 | 22.74 | 10.92 | 30.12 | 4.86 |
| P/B Ratio | — | — | — | — | — | 14.37 | 11.83 | — | 13.26 | 3.67 | 5.48 |
| P/FCF | — | — | — | — | — | — | — | — | — | — | 14.61 |
| P/OCF | — | — | — | — | — | — | 149.93 | — | — | — | 13.98 |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 91.25 | 322.69 | 1155.58 | 50.75 | 51.99 | 25.02 | 26.44 | 10.92 | 23.13 | 4.49 |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | 24.58 |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — | 33.67 |
| EV / FCF | — | — | — | — | — | — | — | — | — | — | 13.50 |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 88.5% | 88.5% | -1737.2% | -4284.1% | -154.6% | -127.1% | -73.7% | -220.5% | -183.0% | -575.5% | 39.5% |
| Operating Margin | -695.4% | -695.4% | -2902.7% | -6589.7% | -342.8% | -264.5% | -168.3% | -368.0% | -282.3% | -848.3% | 17.6% |
| Net Profit Margin | -891.6% | -891.6% | -3191.1% | -6988.6% | -411.2% | -305.7% | -228.0% | -452.9% | -337.4% | -955.9% | 15.5% |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | — | — | — | — | -572.1% | -120.5% | -248.5% | -1622.9% | -156.6% | -125.2% | 20.2% |
| ROA | -55.5% | -55.5% | -53.0% | -57.2% | -41.9% | -31.3% | -30.9% | -48.6% | -42.0% | -55.0% | 11.5% |
| ROIC | -305.3% | -305.3% | -98.7% | -89.3% | -49.7% | -49.0% | -54.6% | -129.2% | -313.8% | -238.6% | 38.4% |
| ROCE | -50.1% | -50.1% | -55.2% | -60.1% | -38.1% | -29.3% | -24.5% | -43.7% | -39.4% | -56.8% | 17.0% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | — | — | — | — | — | 1.11 | 1.23 | — | 1.64 | 0.29 | 0.29 |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | 1.41 |
| Net Debt / Equity | — | — | — | — | — | 0.64 | 0.49 | — | 0.01 | -0.85 | -0.42 |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | -2.03 |
| Debt / FCF | — | — | — | — | — | — | — | — | — | — | -1.12 |
| Interest Coverage | -7.56 | -7.56 | -5.81 | -8.13 | -6.60 | -6.34 | -2.29 | -3.45 | -3.93 | -6.52 | 6.35 |
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 4.53 | 4.53 | 6.17 | 6.12 | 9.40 | 7.45 | 15.20 | 8.98 | 9.36 | 8.45 | 4.77 |
| Quick Ratio | 4.53 | 4.53 | 6.17 | 6.12 | 9.40 | 7.45 | 15.20 | 8.98 | 9.66 | 8.45 | 4.77 |
| Cash Ratio | 4.36 | 4.36 | 5.99 | 5.99 | 9.25 | 6.56 | 14.87 | 8.65 | 8.95 | 8.29 | 4.70 |
| Asset Turnover | — | 0.06 | 0.01 | 0.01 | 0.09 | 0.08 | 0.10 | 0.09 | 0.15 | 0.05 | 0.63 |
| Inventory Turnover | — | — | — | — | — | — | — | — | — | — | — |
| Days Sales Outstanding | — | — | 328.96 | 62.19 | 0.57 | 268.56 | 28.90 | 70.14 | 78.62 | 30.36 | 0.08 |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | — | — | — | — | — | — | — | 3.2% |
| FCF Yield | — | — | — | — | — | — | — | — | — | — | 6.8% |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Shares Outstanding | — | $120M | $112M | $97M | $90M | $77M | $65M | $58M | $54M | $49M | $43M |
Binary Regulatory Approval Risk
Based on reported figures, the company trades at a P/S ratio of 114.98, which suggests that investors are pricing in significant future commercial success for aficamten rather than current fundamental performance, a valuation level that appears highly elevated compared to broader biotechnology sector averages.
The extreme P/S multiple indicates that the market is effectively ignoring current revenue volatility and focusing entirely on the probability-weighted net present value of the pipeline. This valuation implies a high-growth trajectory that remains contingent on successful regulatory outcomes, leaving little margin for error should clinical or commercial milestones face delays.
As reported in financial statements, the company's ROIC has remained deeply negative, reaching -138.9% in 2025Q4, which highlights the structural challenge of compounding capital while the business remains in a pre-commercial phase with heavy, non-productive R&D expenditure.
The persistent decay in returns on invested capital reflects the high cost of late-stage clinical trials that have yet to generate a corresponding return in the form of commercial product sales. Investors should monitor whether the transition to a commercial entity can reverse this trend, as current capital allocation appears to be destroying value rather than compounding it.
According to recent SEC filings, the company's cash conversion cycle is highly erratic, swinging to -2414 days in 2026Q1, which suggests that the timing of milestone-based revenue recognition and supplier payments creates significant noise in standard efficiency metrics.
The extreme fluctuations in the cash conversion cycle are a direct consequence of the milestone-dependent revenue model rather than operational inefficiency in the traditional sense. This lack of consistency makes standard working capital analysis less predictive of future performance, as the metrics are driven by contract accounting rather than inventory turnover or customer payment cycles.
Based on the provided data, the current ratio has compressed from 10.39 in 2024Q2 to 4.21 in 2026Q1, signaling a rapid consumption of liquid assets as the company funds its infrastructure build-out and late-stage clinical development programs.
While the current ratio remains above 1.0, the downward trend is concerning given the company's reliance on cash to sustain its high-burn operating model. The rapid depletion of the cash balance suggests that the company may face liquidity constraints in the near term, potentially necessitating further dilutive financing if commercial revenue does not materialize as expected.
The Price-to-Sales ratio is frequently misapplied to this business model because it treats milestone-based partnership income as equivalent to recurring product revenue, thereby obscuring the company's true lack of a sustainable, scalable commercial foundation.
Investors should instead focus on the cash burn rate relative to the remaining cash runway, as this provides a more accurate assessment of the company's survival probability. Using P/S multiples in a pre-commercial biotech context often leads to an overestimation of value by failing to account for the binary risk inherent in the regulatory approval process.
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Quick answers to the most common questions about buying CYTK stock.
Cytokinetics, Incorporated's current P/E ratio is -13.1x. The historical average is 19.0x.
Based on historical data, Cytokinetics, Incorporated is trading at a P/E of -13.1x. Compare with industry peers and growth rates for a complete picture.
Cytokinetics, Incorporated has 88.5% gross margin and -695.4% operating margin.