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CNTACentessa Pharmaceuticals plc
$40.50$6.3B
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CNTA logoCentessa Pharmaceuticals plc(CNTA)Earnings, Financials & Key Ratios

CNTA•NASDAQ
$40.50
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryDrug Discovery and Antibody Platforms
AboutCentessa Pharmaceuticals plc, a clinical-stage pharmaceutical company, discovers, develops, and delivers medicines to patients. Its registrational pipeline products include Lixivaptan, a vasopressin V2 receptor small molecule inhibitor that is in Phase III clinical development for the treatment of autosomal dominant polycystic kidney disease; and SerpinPC, an activated protein C inhibitor, which is in Phase IIa clinical development for the treatment of hemophilia A and B. The company also has emerging pipeline products under clinical proof of concept stage comprising LB101, a PD-L1xCD47 LockBody, as well as LB201, a PD-L1xCD3 LockBody, which are designed to selectively drive potent CD47 and CD3 effector function activity while avoiding systemic toxicity; ZF874, a small molecule pharmacological chaperone folding corrector of the Z variant of alpha-1-antitrypsin in Phase I clinical development for the treatment of alpha-1-antitrypsin deficiency; MGX292, a recombinant modified BMP9 replacement protein designed to overcome the deficiency in BMP9 signaling in Pulmonary Arterial Hypertension; and OX2R Agonists that are oral and intranasal selective orexin receptor 2 agonists designed to leverage structural insights and to directly target the underlying pathophysiology of orexin neuron loss in Narcolepsy Type 1. In addition, the company has exploratory pipeline products under clinical proof of concept stage containing CBS001, an anti-LIGHT antibody, which preferentially binds the inflammatory membrane form of LIGHT in inflammatory/fibrotic diseases; and CBS004, a humanized mAb specific to BDCA2, expressed exclusively on plasmacytoid dendritic cells in systemic sclerosis, systemic lupus erythematosus, and other autoimmune diseases. Centessa Pharmaceuticals plc was incorporated in 2020 and is based in Altrincham, the United Kingdom.Show more
  • Revenue$15M
  • EBITDA-$208M-3.8%
  • Net Income-$198M+16.2%
  • EPS (Diluted)-1.46+29.1%
  • Gross Margin100%
  • EBITDA Margin-1384.61%
  • Operating Margin-1384.61%
  • Net Margin-1316.88%
  • ROE-42.55%+42.4%

CNTA Price & Volume

Centessa Pharmaceuticals plc (CNTA) stock price & volume — 10-year historical chart

Loading chart...

Clinical Pipeline Burn Outpaces Capital Reserves

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Contracting
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Clinical trial funding shortfall

Key Thesis Takeaways

  • Centessa Pharmaceuticals faces a precarious financial outlook as its clinical-stage business model relies entirely on non-recurring, event-driven revenue that has been absent in eight of the last ten quarters.
  • The company's heavy reliance on stock-based compensation, which frequently exceeds $7 million per quarter, masks the severity of its operational losses and dilutes shareholder value.
  • Investors should remain cautious as the firm's cash reserves have plummeted to $62.4 million as of 2026Q1, signaling an urgent need for potential dilutive financing to sustain its R&D-heavy pipeline.

Verdict Logic

the company's rapid cash depletion, evidenced by a $72.2 million quarterly free cash flow deficit, suggests a high risk of near-term dilutive equity financing.

CNTA Growth Metrics

Centessa Pharmaceuticals plc (CNTA) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-100%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-11.97%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM1.66%

Return on Capital

10 Years-105.5%
5 Years-59.2%
3 Years-43.58%
Last Year-35.71%

CNTA Recent Earnings

Centessa Pharmaceuticals plc (CNTA) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 1/12 qtrs (100%)
Q2 2026Latest
May 5, 2026
Metric
Actual
Est
EPS
$0.52-36.8%
$0.38
Rev
—
—
Q2 2026
Mar 31, 2026
Metric
Actual
Est
EPS
$0.48-29.2%
$0.37
Rev
—
$1M
Q4 2025
Nov 5, 2025
Metric
Actual
Est
EPS
$0.41-5.1%
$0.39
Rev
—
$767,000
Q3 2025
Aug 12, 2025
Metric
Actual
Est
EPS
$0.38-8.6%
$0.35
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 5, 2026
$0.52vs $0.38-36.8%
—
Q2 2026Mar 31, 2026
$0.48vs $0.37-29.2%
—vs $1M
Q4 2025Nov 5, 2025
$0.41vs $0.39-5.1%
—vs $767,000
Q3 2025Aug 12, 2025
$0.38vs $0.35-8.6%
—
Based on last 12 quarters of dataView full earnings history →

Latest CNTA News

Recent stock market news and headlines for Centessa Pharmaceuticals plc (CNTA)

GlobeNewsWire·Jun 22, 2026
Acquisition of Centessa by Lilly Approved by the High Court of Justice of England and Wales

BOSTON and LONDON, June 22, 2026 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage company developing a new class of medicines for the treatment of excessive daytime sleepiness and other neurological conditions, which entered into a definitive agreement on March 31, 2026 relating to its proposed acquisition by Eli Lilly and Company (“Lilly”), through a wholly owned subsidiary, today announced that the High Court of Justice of England and Wales has approved the proposal for Lilly to acquire Centessa for $38.00 in cash per share plus one non-transferable contingent value right (“CVR”) that entitles the holder to receive up to an aggregate of $9.00 subject to the achievement of three milestones, for a total transaction value of approximately $7.8 billion (the “Transaction”).

Peers Comparison

Key metrics vs top competitors for Centessa Pharmaceuticals plc (CNTA)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
CNTA logoCNTACentessa Pharmaceuticals plcCurrent
$40.50$6.27B-27.74—-1316.88%-42.55%—
KYMR logoKYMRKymera Therapeutics, Inc.
$119.24$9.74B-32.31-16.72%-612.17%-25.02%—
IMVT logoIMVTImmunovant, Inc.
$40.09$8.23B-14.47——-68.16%—
ARQT logoARQTArcutis Biotherapeutics, Inc.
$27.67$3.46B-212.8591.34%-0.57%-1.41%—
PRAX logoPRAXPraxis Precision Medicines, Inc.
$323.95$9.36B-24.03-100%—-43.02%—
VERA logoVERAVera Therapeutics, Inc.
$42.96$3.08B-9.22——-74.86%—

Compare CNTA vs Peers

Centessa Pharmaceuticals plc (CNTA) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs KYMR

Most directly comparable listed peer for CNTA.

Scale Benchmark

vs MRK

Larger-name benchmark to compare CNTA against a more recognizable public peer.

Peer Set

Compare Top 5

vs KYMR, IMVT, ARQT, PRAX

CNTA SEC Filings & Documents

Centessa Pharmaceuticals plc (CNTA) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 22, 2026·SEC

Material company update

Mar 31, 2026·SEC

Material company update

Feb 13, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 31, 2026·SEC

FY 2025

Mar 24, 2025·SEC

FY 2024

Mar 28, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 5, 2026·SEC

FY 2025

Nov 5, 2025·SEC

FY 2025

Aug 12, 2025·SEC

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CNTA Frequently Asked Questions

Centessa Pharmaceuticals plc (CNTA) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Centessa Pharmaceuticals plc's revenue?

Centessa Pharmaceuticals plc (CNTA) reported $15.0M in revenue for fiscal year 2025.

Is CNTA profitable?

Centessa Pharmaceuticals plc (CNTA) reported a net loss of $250.6M for fiscal year 2025.

Dividend & Returns
What is CNTA's return on equity?

Centessa Pharmaceuticals plc (CNTA) has a return on equity (ROE) of -42.6%. Negative ROE indicates the company is unprofitable.

What is Centessa Pharmaceuticals plc's free cash flow?

Centessa Pharmaceuticals plc (CNTA) had negative free cash flow of $209.2M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in CNTA back in 2020?

Total return calculator · dividends reinvested · 6+ years of data

See returns →