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CDXSCodexis, Inc.
$2.60$236M
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  4. Financial Ratios

Codexis, Inc. (CDXS) Financial Ratios

Latest Ratios: P/E Ratio -5.2x · EV/EBITDA N/A · ROE -74.9%. (2006–2025 historical series)

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly

CDXS Valuation Multiples

Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Market Cap$236M$142M$350M$208M$305M$2.0B$1.3B$904M$872M$386M$187M
Enterprise Value$259M$164M$391M$159M$234M$1.9B$1.2B$839M$819M$355M$168M
P/E Ratio →-5.20——————————
P/S Ratio3.362.025.902.962.2019.2718.7613.2014.397.723.83
P/B Ratio4.482.815.232.402.1012.287.628.5715.4815.739.79
P/FCF————102.29——————
P/OCF————26.99——————

P/E links to full P/E history page with 30-year chart

CDXS EV Ratios

Enterprise-value multiples — capital-structure-neutral measures of total business value

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
EV / Revenue—2.346.592.261.6918.6116.9712.2613.517.103.44
EV / EBITDA———————————
EV / EBIT———————————
EV / FCF————78.66——————

CDXS Profitability

Margins and return-on-capital ratios measuring operating efficiency

Margins

Full margin charts and quarterly trend are on the Earnings History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Gross Margin86.7%86.7%72.6%81.7%72.6%78.8%80.1%77.2%79.2%71.4%80.0%
Operating Margin-54.5%-54.5%-98.6%-97.0%-25.2%-21.7%-34.6%-18.3%-18.6%-45.9%-17.5%
Net Profit Margin-62.5%-62.5%-110.0%-108.7%-24.2%-20.3%-34.8%-17.4%-18.0%-46.0%-17.5%

Return on Capital

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
ROE-74.9%-74.9%-85.0%-65.9%-21.7%-12.7%-17.4%-14.8%-26.9%-105.4%-40.8%
ROA-29.6%-29.6%-45.7%-39.4%-13.5%-9.1%-13.0%-10.5%-16.5%-51.5%-21.3%
ROIC-31.9%-31.9%-60.5%-91.2%-30.8%-24.1%-41.2%-42.3%-254.5%—-4078.1%
ROCE-30.9%-30.9%-51.8%-45.1%-16.8%-11.1%-14.5%-12.9%-25.1%-88.4%-32.3%

CDXS Leverage & Debt

Solvency and debt-coverage ratios — lower is generally safer

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Debt / Equity1.451.450.890.190.300.290.150.250.000.010.02
Debt / EBITDA———————————
Net Debt / Equity—0.440.61-0.57-0.49-0.42-0.73-0.61-0.94-1.26-0.99
Net Debt / EBITDA———————————
Debt / FCF————-23.63——————
Interest Coverage-8.13-8.13—————————

CDXS Liquidity & Efficiency

Short-term solvency ratios and asset-utilisation metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Current Ratio3.823.824.182.613.324.857.387.423.931.812.20
Quick Ratio3.753.754.102.533.284.827.347.403.891.762.13
Cash Ratio3.093.093.111.822.323.506.015.883.101.251.56
Asset Turnover—0.480.400.510.550.430.310.460.770.931.37
Inventory Turnover5.145.149.054.7718.7419.1514.2642.1321.4313.8311.82
Days Sales Outstanding—55.64116.15103.70107.65131.19154.80107.4681.3386.1044.27

CDXS Shareholder Yields

Earnings, FCF, buyback, and dividend yields — total returns to shareholders

Dividends

Full dividend history and growth charts are on the Dividend History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Dividend Yield———————————
Payout Ratio———————————

Total Shareholder Return Metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Earnings Yield———————————
FCF Yield————1.0%——————
Buyback Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.8%
Total Shareholder Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.8%
Shares Outstanding—$87M$73M$68M$65M$65M$59M$57M$52M$46M$41M

Key Metrics

Growth RegimeMixed
ProfitabilityNegative
Balance SheetVulnerable
Cash FlowBurning
Top Statement Risk

Persistent liquidity and solvency

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2026Q1)

Speculative Pricing Amidst Operational Losses

According to current market data, Codexis trades at a price-to-sales ratio of 3.09, a valuation that appears to price the firm as a high-growth technology platform rather than a specialty chemical manufacturer, despite the absence of positive earnings to support traditional P/E-based valuation metrics.

The lack of a meaningful P/E ratio and the reliance on P/S multiples suggest that investors are valuing the company primarily as a call option on its ECO Synthesis platform. This valuation approach warrants caution, as it assumes future revenue growth will eventually justify current premiums, ignoring the immediate reality of persistent net losses.

Capital Efficiency Remains Structurally Impaired

Based on reported financial figures, the company's ROIC has remained consistently negative, with a recent reading of -7.9% in 2026Q1, indicating that the firm is currently destroying rather than compounding shareholder capital through its ongoing investment in high-cost research and development initiatives.

The inability to generate positive returns on invested capital suggests that the company's proprietary platform has yet to reach the commercial scale necessary to offset its heavy fixed-cost base. Investors should monitor whether the strategic pivot toward RNA synthesis can improve these returns, or if the current capital allocation strategy will continue to erode equity value.

Working Capital Volatility Hinders Operations

As reported in recent quarterly filings, the cash conversion cycle has exhibited extreme volatility, swinging from 21 days in 2025Q4 to 57 days in 2026Q1, which highlights the unpredictable nature of milestone-driven revenue and the resulting pressure on the firm's internal liquidity management.

The erratic nature of the cash conversion cycle suggests that the company lacks the leverage to dictate payment terms with its large-cap pharmaceutical partners. This inefficiency forces the firm to maintain higher cash buffers than would otherwise be necessary, further complicating its already strained liquidity position.

Liquidity Buffer Facing Increasing Pressure

According to the latest balance sheet data, the current ratio of 5.36 appears superficially strong, yet this figure is misleading when viewed against the company's persistent cash burn and the rapid accumulation of debt, which has risen to a D/E ratio of 1.69 as of 2026Q1.

While the current ratio suggests an ability to cover short-term obligations, the underlying trend of rising debt and shrinking cash reserves indicates a narrowing runway. The company's liquidity position appears increasingly vulnerable to any delays in milestone payments or unexpected increases in operational expenditures.

Misapplication of Revenue Multiples in Biotech

The price-to-sales ratio is the most commonly misapplied metric for Codexis, as it obscures the lumpy, non-recurring nature of milestone payments that frequently inflate headline revenue figures without providing the stable, recurring cash flows necessary to support a high valuation multiple.

Analysts should instead focus on normalized revenue streams and the 'Commercial Enzyme Count' to gauge true operational progress. Relying on P/S multiples risks overestimating the company's fundamental value by failing to account for the high probability that current revenue levels may not be sustainable in the absence of new, large-scale partnerships.

Download Financial Ratios Data

Includes 30+ ratios · 20 years · Updated daily

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CDXS — Frequently Asked Questions

Quick answers to the most common questions about buying CDXS stock.

What is Codexis, Inc.'s P/E ratio?

Codexis, Inc.'s current P/E ratio is -5.2x. This places it at the 50th percentile of its historical range.

What is Codexis, Inc.'s ROE?

Codexis, Inc.'s return on equity (ROE) is -74.9%. The historical average is -43.4%.

Is CDXS stock overvalued?

Based on historical data, Codexis, Inc. is trading at a P/E of -5.2x. This is at the 50th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.

What are Codexis, Inc.'s profit margins?

Codexis, Inc. has 86.7% gross margin and -54.5% operating margin.