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ZYMEZymeworks Inc.
$26.72$2.0B
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ZYME logoZymeworks Inc.(ZYME)Earnings, Financials & Key Ratios

ZYME•NASDAQ
$26.72
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutZymeworks Inc., a clinical-stage biopharmaceutical company, discovers, develops, and commercializes biotherapeutics for the treatment of cancer. The company's lead product candidates include zanidatamab, a novel bispecific antibody that is in Phase 1 and Phase 2 clinical trials for the treatment of biliary tract, gastroesophageal adenocarcinomas, breast, and colorectal cancer; and ZW49, a biparatopic anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate that is in Phase 1 clinical trial for the treatment of advanced or metastatic HER2-expressing tumors. The company has strategic partnerships with Merck Sharp & Dohme Research Ltd.; Eli Lilly and Company; Bristol-Myers Squibb company; GlaxoSmithKline Intellectual Property Development Ltd.; Daiichi Sankyo Co., Ltd.; Janssen Biotech, Inc.; BeiGene, Ltd.; and Exelixis, Inc. It also has licensing and research collaboration with LEO Pharma A/S to research, develop, and commercialize bispecific antibodies; and Iconic Therapeutics, Inc. Zymeworks Inc. was incorporated in 2003 and is headquartered in Vancouver, Canada.Show more
  • Revenue$106M+38.9%
  • EBITDA-$81M+35.3%
  • Net Income-$81M+33.9%
  • EPS (Diluted)-1.08+33.3%
  • Gross Margin100%
  • EBITDA Margin-76.84%+53.4%
  • Operating Margin-87.33%+51.4%
  • Net Margin-76.56%+52.4%
  • ROE-26.72%+12.5%

ZYME Price & Volume

Zymeworks Inc. (ZYME) stock price & volume — 10-year historical chart

Loading chart...

Erratic Milestone Revenue Masks Deep Operational Burn

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Imminent liquidity and dilution

Key Thesis Takeaways

  • Zymeworks faces a precarious financial outlook characterized by extreme revenue volatility, as evidenced by a 91.1% year-over-year revenue decline in 2026Q1.
  • The company's reliance on non-recurring milestone payments to fund heavy R&D and SG&A expenditures, which totaled $15.1 billion in 2026Q1, creates significant uncertainty regarding long-term operational sustainability.
  • Investors should remain cautious as the company's $41.2 million cash position appears insufficient to support its current burn rate, likely necessitating dilutive financing in the near term.

Verdict Logic

the company's cash position of $41.2 million against a $47.1 million operating loss in 2026Q1 suggests an imminent liquidity crisis and high risk of shareholder dilution.

ZYME Growth Metrics

Zymeworks Inc. (ZYME) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years27.06%
5 Years22.16%
3 Years-36.43%
TTM-12.98%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM9.7%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM8.05%

Return on Capital

10 Years-32.9%
5 Years-21.87%
3 Years-27.78%
Last Year-27.26%

ZYME Recent Earnings

Zymeworks Inc. (ZYME) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 6/12 qtrs (50%)●Beat Revenue 6/12 qtrs (50%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$0.59-490.0%
$0.10
Rev
$2M-90.1%
$24M
Q2 2026
Mar 2, 2026
Metric
Actual
Est
EPS
$0.55-57.1%
$0.35
Rev
$3M-86.9%
$19M
Q4 2025
Nov 6, 2025
Metric
Actual
Est
EPS
$0.26+13.3%
$0.30
Rev
$28M+41.7%
$19M
Q3 2025
Aug 7, 2025
Metric
Actual
Est
EPS
$0.03+105.8%
$0.52
Rev
$49M+89.3%
$26M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$0.59vs $0.10-490.0%
$2Mvs $24M-90.1%
Q2 2026Mar 2, 2026
$0.55vs $0.35-57.1%
$3Mvs $19M-86.9%
Q4 2025Nov 6, 2025
$0.26vs $0.30+13.3%
$28Mvs $19M+41.7%
Q3 2025Aug 7, 2025
$0.03vs $0.52+105.8%
$49Mvs $26M+89.3%
Based on last 12 quarters of dataView full earnings history →

Latest ZYME News

Recent stock market news and headlines for Zymeworks Inc. (ZYME)

Seeking Alpha·6 days ago
Here's Why Zymeworks Inc. Paid $929M For Theravance Biopharma

Zymeworks Inc. acquires Theravance Biopharma for $929M, pivoting to a hybrid biotech and royalty/cash-flow platform anchored by Yupelri. ZYME gains durable, growing cash flows—$60M annually from Yupelri—with patent protection to 2039, supporting internal R&D and reducing reliance on equity issuance. The acquisition's innovative financing structure ringfences risk, offers immediate accretion, and diversifies revenue beyond oncology, enhancing earnings visibility.

Zacks Investment Research·Jun 30, 2026
Theravance Stock Down 3% After Zymeworks Announces Buyout

TBPH falls after agreeing to a $929 million all-cash acquisition by Zymeworks, following a strategic review triggered by its failed ampreloxetine program.

Seeking Alpha·Jun 29, 2026
Zymeworks Inc. (ZYME) M&A Call Transcript

Zymeworks Inc. (ZYME) M&A Call Transcript

Benzinga·Jun 29, 2026
Zymeworks Targets Long-Term Cash Generation Through Theravance Acquisition

Zymeworks Inc. (NASDAQ:ZYME) said Monday it has agreed to acquire Theravance Biopharma Inc. (NASDAQ:TBPH) in an all-cash transaction valued at about $929 million.

Reuters·Jun 29, 2026
Zymeworks strikes $929 million deal for Theravance Biopharma

Drugmaker ​Zymeworks ‌said ​on ​Monday ⁠it ​will ​buy ​Theravance ​Biopharma in ‌a $929 ⁠million ​deal.

Peers Comparison

Key metrics vs top competitors for Zymeworks Inc. (ZYME)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ZYME logoZYMEZymeworks Inc.Current
$26.72$1.97B-24.7438.87%-76.56%-26.72%—
IMVT logoIMVTImmunovant, Inc.
$40.09$8.23B-14.47——-68.16%—
RCUS logoRCUSArcus Biosciences, Inc.
$30.25$3.05B-9.19-4.26%-156.36%-68.97%—
MRUS logoMRUSMerus N.V.
$90.00$6.83B-26.87-12.38%-654.43%-50.62%—
AGIO logoAGIOAgios Pharmaceuticals, Inc.
$44.01$2.62B-6.1848.03%-639.84%-34.11%—
TPST logoTPSTTempest Therapeutics, Inc.
$0.99$4.4M-0.16——-729.89%—

Compare ZYME vs Peers

Zymeworks Inc. (ZYME) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IMVT

Most directly comparable listed peer for ZYME.

Scale Benchmark

vs LLY

Larger-name benchmark to compare ZYME against a more recognizable public peer.

Peer Set

Compare Top 5

vs IMVT, RCUS, MRUS, AGIO

ZYME SEC Filings & Documents

Zymeworks Inc. (ZYME) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 14, 2026·SEC

Material company update

May 7, 2026·SEC

Material company update

Apr 1, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 2, 2026·SEC

FY 2025

Mar 5, 2025·SEC

FY 2024

Mar 6, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 7, 2025·SEC

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ZYME Frequently Asked Questions

Zymeworks Inc. (ZYME) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Zymeworks Inc.'s revenue?

Zymeworks Inc. (ZYME) reported $81.3M in revenue for fiscal year 2025. This represents a 4766% increase from $1.7M in 2014.

How fast is Zymeworks Inc. growing?

Zymeworks Inc. (ZYME) grew revenue by 38.9% over the past year. This is strong growth.

Is ZYME profitable?

Zymeworks Inc. (ZYME) reported a net loss of $102.7M for fiscal year 2025.

Dividend & Returns
What is ZYME's return on equity?

Zymeworks Inc. (ZYME) has a return on equity (ROE) of -26.7%. Negative ROE indicates the company is unprofitable.

What is Zymeworks Inc.'s free cash flow?

Zymeworks Inc. (ZYME) had negative free cash flow of $45.75B in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ZYME back in 2014?

Total return calculator · dividends reinvested · 12+ years of data

See returns →