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PRTAProthena Corporation plc
$9.68$507M
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PRTA logoProthena Corporation plc(PRTA)Earnings, Financials & Key Ratios

PRTA•NASDAQ
$9.68
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutProthena Corporation plc, a late-stage clinical company, focuses on discovery and development of novel therapies for life-threatening diseases in the United States. The company is involved in developing Birtamimab, an investigational humanized antibody that is in Phase III clinical trial for the treatment of AL amyloidosis; Prasinezumab, a humanized monoclonal antibody, which is in Phase IIb clinical trial for the treatment of Parkinson's disease; PRX004 that completed Phase I clinical trial for the treatment of Transthyretin amyloidosis; and PRX005, which is in Phase I clinical trial for the treatment of Alzheimer's disease. Its discovery and preclinical programs include PRX012 for the treatment of Alzheimer's disease; and dual Aß-Tau vaccine for the treatment and prevention of Alzheimer's disease. Prothena Corporation plc has a license, development, and commercialization agreement with F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. to develop and commercialize antibodies that target alpha-synuclein; and a collaboration agreement with Bristol-Myers Squibb to develop antibodies. The company was founded in 2012 and is based in Dublin, Ireland.Show more
  • Revenue$10M-92.8%
  • EBITDA-$181M-17.7%
  • Net Income-$244M-99.6%
  • EPS (Diluted)-4.53-99.6%
  • Gross Margin61.77%-38.2%
  • EBITDA Margin-1867.6%-1542.6%
  • Operating Margin-1905.82%-1566.6%
  • Net Margin-2520.57%-2685.3%
  • ROE-63.62%-172.6%

PRTA Price & Volume

Prothena Corporation plc (PRTA) stock price & volume — 10-year historical chart

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Milestone Dependency Masks Underlying Clinical Cash Burn

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Adequate
Cash Flow:Burning
Primary Risk:Clinical milestone dependency

Key Thesis Takeaways

  • Prothena’s financial profile is defined by extreme revenue volatility, as evidenced by a 92.84% year-over-year decline in specific periods, driven by a reliance on non-recurring milestone payments rather than sustainable commercial operations.
  • While the company maintains a current ratio of 10.43, the steady erosion of cash reserves from $618.8 million in 2023Q4 to $329.5 million in 2026Q1 highlights the significant capital intensity required to fund its late-stage pipeline.
  • Investors should remain cautious, as the occasional profitability, such as the $32.7 million net income in 2026Q1, appears to be an accounting anomaly that fails to mask the persistent structural challenges of its R&D-heavy business model.

Verdict Logic

the company's reliance on unpredictable milestone payments to offset its $1.3 billion accumulated deficit creates significant liquidity risk for long-term investors.

PRTA Growth Metrics

Prothena Corporation plc (PRTA) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years19.68%
5 Years62.56%
3 Years-43.57%
TTM-57.99%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-37.1%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-35.58%

Return on Capital

10 Years-26.78%
5 Years-21.35%
3 Years-34.19%
Last Year-47.05%

PRTA Recent Earnings

Prothena Corporation plc (PRTA) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 5/12 qtrs (42%)●Beat Revenue 4/12 qtrs (33%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$0.52+267.7%
$0.31
Rev
$51M+6215.2%
$808,909
Q1 2026
Feb 19, 2026
Metric
Actual
Est
EPS
$0.44+2.2%
$0.45
Rev
$21,000-98.4%
$1M
Q4 2025
Nov 6, 2025
Metric
Actual
Est
EPS
$0.67-11.7%
$0.60
Rev
$2M+262.2%
$666,670
Q3 2025
Aug 4, 2025
Metric
Actual
Est
EPS
$1.86-67.6%
$1.11
Rev
$4M-33.4%
$7M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$0.52vs $0.31+267.7%
$51Mvs $808,909+6215.2%
Q1 2026Feb 19, 2026
$0.44vs $0.45+2.2%
$21,000vs $1M-98.4%
Q4 2025Nov 6, 2025
$0.67vs $0.60-11.7%
$2Mvs $666,670+262.2%
Q3 2025Aug 4, 2025
$1.86vs $1.11-67.6%
$4Mvs $7M-33.4%
Based on last 12 quarters of dataView full earnings history →

Latest PRTA News

Recent stock market news and headlines for Prothena Corporation plc (PRTA)

Zacks Investment Research·Jun 24, 2026
SRPT or PRTA: Which Is the Better Value Stock Right Now?

Investors interested in Medical - Biomedical and Genetics stocks are likely familiar with Sarepta Therapeutics (SRPT) and Prothena (PRTA). But which of these two stocks is more attractive to value investors?

Peers Comparison

Key metrics vs top competitors for Prothena Corporation plc (PRTA)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
PRTA logoPRTAProthena Corporation plcCurrent
$9.68$506.78M-2.14-92.84%-2520.57%-63.62%—
FOLD logoFOLDAmicus Therapeutics, Inc.
$14.49$4.55B-164.8520.05%-4.27%-12.02%—
RARE logoRAREUltragenyx Pharmaceutical Inc.
$35.87$3.53B-6.1520.13%-91.03%——
IONS logoIONSIonis Pharmaceuticals, Inc.
$86.33$14.27B-36.2733.87%-30.87%-58.57%—
ALNY logoALNYAlnylam Pharmaceuticals, Inc.
$321.59$42.91B138.0265.19%13.46%98.29%—
RCUS logoRCUSArcus Biosciences, Inc.
$30.25$3.05B-9.19-4.26%-156.36%-68.97%—

Compare PRTA vs Peers

Prothena Corporation plc (PRTA) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs FOLD

Most directly comparable listed peer for PRTA.

Scale Benchmark

vs JNJ

Larger-name benchmark to compare PRTA against a more recognizable public peer.

Peer Set

Compare Top 5

vs FOLD, RARE, IONS, ALNY

PRTA SEC Filings & Documents

Prothena Corporation plc (PRTA) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 15, 2026·SEC

Material company update

May 7, 2026·SEC

Material company update

Feb 27, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 27, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 22, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 4, 2025·SEC

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PRTA Frequently Asked Questions

Prothena Corporation plc (PRTA) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Prothena Corporation plc's revenue?

Prothena Corporation plc (PRTA) reported $57.9M in revenue for fiscal year 2025. This represents a 4561% increase from $1.2M in 2010.

How fast is Prothena Corporation plc growing?

Prothena Corporation plc (PRTA) saw revenue decline by 92.8% over the past year.

Is PRTA profitable?

Prothena Corporation plc (PRTA) reported a net loss of $151.2M for fiscal year 2025.

Dividend & Returns
What is PRTA's return on equity?

Prothena Corporation plc (PRTA) has a return on equity (ROE) of -63.6%. Negative ROE indicates the company is unprofitable.

What is Prothena Corporation plc's free cash flow?

Prothena Corporation plc (PRTA) had negative free cash flow of $81.4M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in PRTA back in 2010?

Total return calculator · dividends reinvested · 16+ years of data

See returns →