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CRNXCrinetics Pharmaceuticals, Inc.
$42.03$4.4B
Overview & Verdict
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CRNX logoCrinetics Pharmaceuticals, Inc.(CRNX)Earnings, Financials & Key Ratios

CRNX•NASDAQ
$42.03
Price updated Jul 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Rare Disease Biopharma
AboutCrinetics Pharmaceuticals, Inc., a clinical stage pharmaceutical company, focuses on the discovery, development, and commercialization of therapeutics for rare endocrine diseases and endocrine-related tumors. Its lead product candidate is Paltusotine, an oral selective nonpeptide somatostatin receptor type 2 agonist that has completed phase III clinical trial for the treatment of acromegaly, as well as completed phase II clinical trial to treat carcinoid syndrome and nonfunctional neuroendocrine tumors (NETs). The company is also developing CRN04777, an oral selective nonpeptide somatostatin type 5 receptor agonist, which is in phase I clinical trial for the treatment of congenital hyperinsulinism; and CRN04894, an oral adrenocorticotrophic hormone antagonist that is in phase I clinical trial for the treatment of Cushing's and congenital adrenal hyperplasia diseases. Crinetics Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in San Diego, California.Show more
  • Revenue$8M+640.7%
  • EBITDA-$513M-52.6%
  • Net Income-$465M-55.9%
  • EPS (Diluted)-4.95-34.1%
  • Gross Margin86.02%-14.0%
  • EBITDA Margin-6664.23%+79.4%
  • Operating Margin-6714.77%+79.4%
  • Net Margin-6046.22%+78.9%
  • ROE-40.17%-25.4%

CRNX Price & Volume

Crinetics Pharmaceuticals, Inc. (CRNX) stock price & volume — 10-year historical chart

Loading chart...

Clinical Development Costs Outpace Milestone Revenue Growth

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Clinical trial binary dependency

Key Thesis Takeaways

  • Crinetics Pharmaceuticals remains a high-risk, pre-commercial entity heavily dependent on clinical trial success to justify its $1.3B equity valuation.
  • While the company demonstrates a 28.7% year-over-year revenue growth rate as of 2026Q1, this is driven by volatile, non-recurring milestones rather than sustainable product sales.
  • Investors should remain cautious as the firm faces an accelerating cash burn, with quarterly free cash flow outflows reaching $125.5M, necessitating potential future equity dilution to sustain operations.

Verdict Logic

the company's reliance on non-recurring revenue and an accelerating quarterly cash burn of $125.5M in 2026Q1 present significant binary risks that outweigh current fundamental stability.

CRNX Growth Metrics

Crinetics Pharmaceuticals, Inc. (CRNX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years155.27%
3 Years17.56%
TTM2277.5%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-51.22%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-34.55%

Return on Capital

10 Years-46.05%
5 Years-43.8%
3 Years-41.9%
Last Year-42.61%

CRNX Recent Earnings

Crinetics Pharmaceuticals, Inc. (CRNX) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 2/12 qtrs (17%)●Beat Revenue 7/12 qtrs (78%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$1.23-0.8%
$1.22
Rev
$11M+26.1%
$9M
Q1 2026
Feb 26, 2026
Metric
Actual
Est
EPS
$1.29+5.8%
$1.37
Rev
$6M+37.2%
$4M
Q4 2025
Nov 6, 2025
Metric
Actual
Est
EPS
$1.38-8.7%
$1.27
Rev
$143,000-96.7%
$4M
Q3 2025
Aug 7, 2025
Metric
Actual
Est
EPS
$1.23-8.8%
$1.13
Rev
$1M+161.7%
$394,000
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$1.23vs $1.22-0.8%
$11Mvs $9M+26.1%
Q1 2026Feb 26, 2026
$1.29vs $1.37+5.8%
$6Mvs $4M+37.2%
Q4 2025Nov 6, 2025
$1.38vs $1.27-8.7%
$143,000vs $4M-96.7%
Q3 2025Aug 7, 2025
$1.23vs $1.13-8.8%
$1Mvs $394,000+161.7%
Based on last 12 quarters of dataView full earnings history →

Latest CRNX News

Recent stock market news and headlines for Crinetics Pharmaceuticals, Inc. (CRNX)

GlobeNewsWire·6 days ago
Crinetics Pharmaceuticals to Report Second Quarter 2026 Financial Results on August 4, 2026

SAN DIEGO, June 30, 2026 (GLOBE NEWSWIRE) -- Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX) today announced that it will report second quarter 2026 financial results on Tuesday, August 4, 2026 after the market closes. Company management will host a conference call at 4:30 p.m. ET to discuss financial results and provide a business update.

Seeking Alpha·Jun 25, 2026
Crinetics Pharmaceuticals: 'Buy' On Palsonify Market Expansion And Atumelnant Advancements

Crinetics Pharmaceuticals maintains a 'Buy' rating due to EU approval and strong initial U.S. uptake of Palsonify for acromegaly. The company advances atumelnant, its oral ACTH receptor antagonist, with promising phase 2 data for CAH and ACTH-dependent Cushing's syndrome. Q1 2026 Palsonify revenues reached $10.3M, beating expectations, but the company's cash runway remains limited to at least 12 months.

24/7 Wall Street·Jun 25, 2026
3 Under-the-Radar Biotech Takeover Targets for the Next Pharma Buying Spree

Large-cap pharma is back in the deal market. AbbVie's (NASDAQ: ABBV | ABBV Price Prediction) pending acquisition of Apogee Therapeutics signaled that big buyers will pay up for de-risked clinical assets.

Peers Comparison

Key metrics vs top competitors for Crinetics Pharmaceuticals, Inc. (CRNX)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
CRNX logoCRNXCrinetics Pharmaceuticals, Inc.Current
$42.03$4.43B-8.49640.71%-6046.22%-40.17%—
RCUS logoRCUSArcus Biosciences, Inc.
$29.98$3.02B-9.11-4.26%-156.36%-68.97%—
CHRS logoCHRSCoherus Oncology, Inc.
$1.56$190.96M-1.08-84.2%-323.49%-174.71%—
ACVA logoACVAACV Auctions Inc.
$7.43$1.3B-19.0519.22%-7.97%-14.27%—
ACAD logoACADACADIA Pharmaceuticals Inc.
$25.77$4.41B11.2511.87%34.3%35.65%—
NVAX logoNVAXNovavax, Inc.
$9.35$1.54B3.6864.69%-14.73%——

Compare CRNX vs Peers

Crinetics Pharmaceuticals, Inc. (CRNX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RCUS

Most directly comparable listed peer for CRNX.

Scale Benchmark

vs NVS

Larger-name benchmark to compare CRNX against a more recognizable public peer.

Peer Set

Compare Top 5

vs RCUS, CHRS, ACVA, ACAD

CRNX SEC Filings & Documents

Crinetics Pharmaceuticals, Inc. (CRNX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 7, 2026·SEC

Material company update

Apr 10, 2026·SEC

Material company update

Mar 23, 2026·SEC

10-K Annual Reports

2
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 27, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 7, 2025·SEC

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CRNX Frequently Asked Questions

Crinetics Pharmaceuticals, Inc. (CRNX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Crinetics Pharmaceuticals, Inc.'s revenue?

Crinetics Pharmaceuticals, Inc. (CRNX) reported $18.1M in revenue for fiscal year 2025. This represents a 2968% increase from $0.6M in 2016.

How fast is Crinetics Pharmaceuticals, Inc. growing?

Crinetics Pharmaceuticals, Inc. (CRNX) grew revenue by 640.7% over the past year. This is strong growth.

Is CRNX profitable?

Crinetics Pharmaceuticals, Inc. (CRNX) reported a net loss of $496.4M for fiscal year 2025.

Dividend & Returns
What is CRNX's return on equity?

Crinetics Pharmaceuticals, Inc. (CRNX) has a return on equity (ROE) of -40.2%. Negative ROE indicates the company is unprofitable.

What is Crinetics Pharmaceuticals, Inc.'s free cash flow?

Crinetics Pharmaceuticals, Inc. (CRNX) had negative free cash flow of $419.5M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in CRNX back in 2016?

Total return calculator · dividends reinvested · 10+ years of data

See returns →