Tenax Therapeutics, Inc. is downgraded from Buy to Hold ahead of a major August 2026 phase 3 data readout for TNX-103 in PH-HFpEF. TNX-103 targets a large, unmet market with no approved therapies, but phase 3 success is uncertain despite promising phase 2 secondary endpoint results relating to 6MWD. The phase 3 LEVEL study is powered >90% to detect a 25-meter 6MWD change, but failure could cut TENX shares by 50% or more.