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SYRESpyre Therapeutics, Inc.
$88.89$30.8B
Overview & Verdict
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SYRE logoSpyre Therapeutics, Inc.(SYRE)Earnings, Financials & Key Ratios

SYRE•NASDAQ
$88.89
Price updated Jul 2, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryImmunology and Inflammation Therapies
AboutSpyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.Show more
  • Revenue$0
  • EBITDA-$200M+4.0%
  • Net Income-$155M+25.4%
  • EPS (Diluted)-1.98+37.7%
  • ROE-25.17%+57.5%

SYRE Price & Volume

Spyre Therapeutics, Inc. (SYRE) stock price & volume — 10-year historical chart

Loading chart...

Aggressive Clinical Development Drives Persistent Capital Burn

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Clinical trial funding shortfall

Key Thesis Takeaways

  • Spyre Therapeutics is currently navigating a high-risk transition into IBD-focused combination therapies, characterized by a complete lack of recurring revenue and an accumulated deficit that has reached $1.2B as of 2026Q1.
  • While the company's YTE half-life extension platform represents a significant technological bet, the firm's reliance on external capital to fund R&D expenses—which peaked at $60.4M in 2026Q1—creates a binary risk profile for investors.
  • Future performance remains entirely contingent on successful clinical trial milestones, as the current financial trajectory suggests a tightening liquidity buffer that may necessitate further dilutive financing.

Verdict Logic

the company's cash position has dropped to $97.2M in 2026Q1 from a high of $227.6M in 2024Q1, indicating a rapid depletion of capital that poses a significant risk to long-term shareholder value.

SYRE Growth Metrics

Spyre Therapeutics, Inc. (SYRE) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM14.12%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM12.4%

Return on Capital

10 Years-75.43%
5 Years-77.05%
3 Years-71.15%
Last Year-32.91%

SYRE Recent Earnings

Spyre Therapeutics, Inc. (SYRE) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 6/12 qtrs (50%)●Beat Revenue 2/12 qtrs (67%)
Q2 2026Latest
May 5, 2026
Metric
Actual
Est
EPS
$0.74-12.1%
$0.66
Rev
—
—
Q1 2026
Feb 19, 2026
Metric
Actual
Est
EPS
$0.70-6.1%
$0.66
Rev
$90M-36.7%
$143M
Q4 2025
Nov 4, 2025
Metric
Actual
Est
EPS
$0.15+77.9%
$0.68
Rev
—
—
Q3 2025
Aug 5, 2025
Metric
Actual
Est
EPS
$0.49+32.9%
$0.73
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 5, 2026
$0.74vs $0.66-12.1%
—
Q1 2026Feb 19, 2026
$0.70vs $0.66-6.1%
$90Mvs $143M-36.7%
Q4 2025Nov 4, 2025
$0.15vs $0.68+77.9%
—
Q3 2025Aug 5, 2025
$0.49vs $0.73+32.9%
—
Based on last 12 quarters of dataView full earnings history →

Latest SYRE News

Recent stock market news and headlines for Spyre Therapeutics, Inc. (SYRE)

GlobeNewsWire·4 days ago
Spyre Therapeutics Announces Grants of Inducement Awards

WALTHAM, Mass., July 02, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients, today announced that Spyre's independent Compensation Committee of the Board of Directors approved the grant of stock options to purchase an aggregate of 58,843 shares of common stock of Spyre and 2,134 restricted stock units (“RSUs”) to six non-executive employees as equity inducement awards under the Spyre Therapeutics, Inc. 2018 Equity Inducement Plan, as amended (the “2018 Plan”). The stock options and RSUs were approved on July 1, 2026 and were material to each employee's acceptance of employment with Spyre, in accordance with Nasdaq Listing Rule 5635(c)(4).

Seeking Alpha·6 days ago
Spyre Therapeutics: Deep And Diverse Immunology Pipeline Awaiting Data

Spyre Therapeutics is building a long-acting antibody platform across IBD and rheumatology. However, they only have Phase 2 assets, with SPY001 and SPY002 that recently showed encouraging Part A data. We still need to wait to see their placebo-controlled data, as well as their combo therapy data.

Zacks Investment Research·Jun 29, 2026
Is SYRE Stock a Buy Now or a Wait-and-See Biotech Story Today

Spyre Therapeutics  SYRE has given investors a classic biotech dilemma. The pipeline is advancing, the cash balance is large and the stock has already moved sharply higher.

Zacks Investment Research·Jun 29, 2026
Spyre Therapeutics Stock Outlook Hinges on 2026 Study Catalysts

Spyre Therapeutics  SYRE has become a closely watched clinical-stage biotech stock as investors look ahead to a busy stretch of data readouts that could define the company's next phase. The company is focused on inflammatory bowel disease, or IBD, where it is developing long-acting antibodies and antibody combinations aimed at improving disease control, convenience and durability of response.

Zacks Investment Research·Jun 29, 2026
SYRE and Spyre Ride New IBD Trends in Biotech Drug Design

SYRE is targeting major IBD drug trends with long-acting antibodies and combination therapies, but its future still hinges on clinical trial results.

Peers Comparison

Key metrics vs top competitors for Spyre Therapeutics, Inc. (SYRE)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
SYRE logoSYRESpyre Therapeutics, Inc.Current
$88.89$30.76B-44.89——-25.17%—
ARRY logoARRYArray Technologies, Inc.
$7.17$1.1B-9.8240.22%-5.56%-20.64%—
PRTA logoPRTAProthena Corporation plc
$9.58$501.54M-2.11-92.84%-260.92%-49.88%—
TRMB logoTRMBTrimble Inc.
$52.53$12.44B30.02-2.61%12.37%7.95%—
PTGX logoPTGXProtagonist Therapeutics, Inc.
$125.17$8.05B-61.06-89.41%-648.27%-17.76%—
TERN logoTERNTerns Pharmaceuticals, Inc.
$52.95$4.77B-51.41——-20.02%—

Compare SYRE vs Peers

Spyre Therapeutics, Inc. (SYRE) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ARRY

Most directly comparable listed peer for SYRE.

Scale Benchmark

vs LLY

Larger-name benchmark to compare SYRE against a more recognizable public peer.

Peer Set

Compare Top 5

vs ARRY, PRTA, TRMB, PTGX

SYRE SEC Filings & Documents

Spyre Therapeutics, Inc. (SYRE) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 5, 2026·SEC

Material company update

Apr 16, 2026·SEC

Material company update

Apr 13, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 19, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 29, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 5, 2026·SEC

FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 5, 2025·SEC

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SYRE Frequently Asked Questions

Spyre Therapeutics, Inc. (SYRE) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Spyre Therapeutics, Inc.'s revenue?

Spyre Therapeutics, Inc. (SYRE) reported $90.5M in revenue for fiscal year 2025.

Is SYRE profitable?

Spyre Therapeutics, Inc. (SYRE) reported a net loss of $179.4M for fiscal year 2025.

Dividend & Returns
What is SYRE's return on equity?

Spyre Therapeutics, Inc. (SYRE) has a return on equity (ROE) of -25.2%. Negative ROE indicates the company is unprofitable.

What is Spyre Therapeutics, Inc.'s free cash flow?

Spyre Therapeutics, Inc. (SYRE) had negative free cash flow of $185.8M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in SYRE back in 2014?

Total return calculator · dividends reinvested · 12+ years of data

See returns →