Spero Therapeutics, Inc. (SPRO) Price Target Analysis
Analyst Rating: Buy
Based on 13 analystsNo Target Data
SPRO trades at Wall Street's consensus target of —.
Current Price$2.16
Average Target—
Low—
Median—
High—
Analyst Target Range
Forward P/E—
PEG Ratio—
Implied Growth-209.0%
(Declining)
Analyst Spread—
Price Forecast (1 Year)
Last 12 months price action with 12-month analyst target path
Consensus Scenario Assumptions
The base valuation assumes SPRO achieves its forward estimates and maintains a stable P/E multiple of historical averagesx. This scenario reflects the blended consensus of 13 Wall Street analysts, balancing both positive catalysts and macroeconomic headwinds over the next 12 months.
SPRO Price Target Analysis
Updated July 8, 2026As of July 8, 2026, Spero Therapeutics, Inc. (SPRO) has a Wall Street consensus price target of N/A, based on estimates from 13 covering analysts. The company has a market capitalization of $125M.
Analyst price targets range from a low of N/A to a high of N/A.
The current analyst consensus rating is Buy, with 6 analysts rating the stock as a Buy or Strong Buy,5 rating it Hold, and 2 rating it Sell or Strong Sell. The mixed ratings reflect uncertainty about near-term direction.
From a valuation perspective, SPRO trades at a trailing P/E of 14.4x. Analysts expect EPS to grow -209.0% over the next year.
Our proprietary valuation model, which blends historical multiples with forward estimates, suggests a base-case price target of $6.80, with bear and bull scenarios of $4.29 and $8.96 respectively. Model confidence stands at 49/100, suggesting limited visibility into future performance.
Investment Context: Price targets represent analyst expectations for the next 12 months and should be considered alongside your own research. Targets are based on analysts' assumptions about earnings growth, margins, and market conditions which may change. For sector-specific context, view other Healthcare stocks.
Analyst Sentiment Comparison
Industry Peer AnalysisAvg Peer Upside
+65.9%
Industry Consensus
Avg Forward P/E
22.7x
(Fair)
Peers with Coverage
9 / 10
Active Analyst Tracking
| Company | Market Cap | Price | Target | Upside Potential | Rating | Fwd P/E | Analysts |
|---|---|---|---|---|---|---|---|
 VNDAVanda Pharmaceuticals Inc. | $378M | $6.39 | $21.00 | +228.6% | Buy | — | 19 |
 PRAXPraxis Precision Medicines, Inc. | $9.4B | $323.95 | $589.00 | +81.8% | Buy | — | 16 |
 NAOVNanoVibronix, Inc. | $512711 | $1.90 | — | — | — | — | — |
 AGENAgenus Inc. | $146M | $3.50 | $7.33 | +109.4% | Buy | 4.5x | 11 |
 TBPHTheravance Biopharma, Inc. | $875M | $16.98 | $14.00 | -17.6% | Hold | 6.8x | 17 |
 IDYAIDEAYA Biosciences, Inc. | $3.6B | $40.51 | $58.67 | +44.8% | Buy | — | 25 |
 NKTRNektar Therapeutics | $1.5B | $74.90 | $149.60 | +99.7% | Buy | — | 33 |
 ACADACADIA Pharmaceuticals Inc. | $4.5B | $26.20 | $34.38 | +31.2% | Buy | 68.9x | 37 |
 PFEPfizer Inc. | $136.9B | $24.07 | $26.75 | +11.1% | Hold | 8.1x | 39 |
 MRKMerck & Co., Inc. | $318.3B | $128.86 | $133.77 | +3.8% | Buy | 25.1x | 37 |
SPRO — Frequently Asked Questions
Quick answers to the most common questions about buying SPRO stock.
What is the SPRO stock price target for 2026?
The consensus price target for SPRO is $N/A, close to the current price of $2.16 (N/A% implied move). Based on 13 analyst estimates, the stock appears fairly valued near current levels.
Is SPRO a buy, sell, or hold?
SPRO has a consensus rating of "Buy" based on 13 Wall Street analysts. The rating breakdown is mixed, with 5 Hold ratings making up the largest segment. The consensus 12-month price target of $N/A implies N/A% upside from current levels.
Is SPRO stock overvalued or undervalued?
SPRO's current price is $2.16 with a consensus target of $N/A (N/A% implied move). Analyst estimates suggest the stock is fairly valued at current levels.
How high can SPRO stock go?
The most bullish Wall Street analyst has a price target of $N/A for SPRO, while the most conservative target is $N/A. The consensus of $N/A represents the median expectation. Our quantitative valuation model projects a bull case target of $9 based on optimistic growth and margin assumptions. These targets typically reflect 12-month expectations.
How many analysts cover SPRO stock?
SPRO is moderately covered, with 13 analysts providing price targets and ratings. Of these, 0 have Strong Buy ratings, 6 have Buy ratings, 5 recommend Hold, and 2 have Sell or Strong Sell ratings. Higher analyst coverage generally indicates greater institutional interest and more reliable consensus estimates.
What is the SPRO stock forecast?
The 12-month SPRO stock forecast based on 13 Wall Street analysts shows a consensus price target of $N/A, with estimates ranging from $N/A (bear case) to $N/A (bull case). The median consensus rating is "Buy". Our proprietary valuation model produces a base case fair value of $7, with bear/bull scenarios of $4/$9.
What is SPRO's fair value based on fundamentals?
Our quantitative valuation model calculates SPRO's fair value at $7 (base case), with a bear case of $4 and bull case of $9. The model uses discounted cash flow analysis, historical growth rates, and margin mean-reversion to project FY+2 earnings, then applies an appropriate P/E multiple. The model confidence score is 49/100.
Should I buy SPRO stock?
SPRO appears fairly valued according to analysts, with a "Buy" rating and minimal upside to the $N/A target. Consider your investment thesis and risk tolerance. This information is for educational purposes only. Always conduct your own research, consider your financial situation, and consult a financial advisor before making investment decisions.
Why do SPRO price targets vary so much?
SPRO analyst price targets range from $N/A to $N/A, a NaN% tight range reflecting strong analyst consensus. Differences stem from varying assumptions about revenue growth, profit margins, competitive dynamics, and valuation multiples. The $N/A consensus represents the middle ground. Our model's $4-$9 range provides an independent fundamental perspective.
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