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SLNOSoleno Therapeutics, Inc.
$53.01$2.8B
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Soleno Therapeutics, Inc. (SLNO) Financial Ratios

Latest Ratios: P/E Ratio 135.9x · EV/EBITDA 158.9x · ROE 6.0%. (2012–2025 historical series)

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly

SLNO Valuation Multiples

Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Market Cap$2.8B$2.5B$1.8B$664M$83M$164M$604M$502M$179M$81M$63M
Enterprise Value$2.7B$2.4B$1.8B$495M$69M$143M$555M$481M$156M$64M$60M
P/E Ratio →135.92118.72—————————
P/S Ratio14.5113.21————————43.29
P/B Ratio6.405.597.374.218.039.1913.2733.585.903.0518.28
P/FCF59.1353.84—————————
P/OCF59.0453.75—————————

P/E links to full P/E history page with 30-year chart

SLNO EV Ratios

Enterprise-value multiples — capital-structure-neutral measures of total business value

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
EV / Revenue—12.86————————41.41
EV / EBITDA158.87144.29—————————
EV / EBIT180.3092.85—————————
EV / FCF—52.39—————————

SLNO Profitability

Margins and return-on-capital ratios measuring operating efficiency

Margins

Full margin charts and quarterly trend are on the Earnings History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Gross Margin98.6%98.6%———————100.1%-4.0%
Operating Margin7.9%7.9%———————0.8%-938.1%
Net Profit Margin11.0%11.0%———————1.0%-831.6%

Return on Capital

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
ROE6.0%6.0%-87.4%-46.5%-171.0%-97.6%-81.5%-135.7%-46.8%-104.6%-362.4%
ROA4.7%4.7%-68.7%-37.6%-77.6%-61.5%-47.8%-75.7%-32.5%-70.3%-175.3%
ROIC3.8%3.8%-142.0%————-1898.3%-128.1%-180.0%-1439.3%
ROCE3.7%3.7%-78.0%-43.9%-104.4%-75.1%-71.3%-62.3%-36.4%-59.2%-307.0%

SLNO Leverage & Debt

Solvency and debt-coverage ratios — lower is generally safer

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Debt / Equity0.010.010.220.000.010.030.000.02———
Debt / EBITDA0.160.16—————————
Net Debt / Equity—-0.15-0.14-1.07-1.40-1.17-1.08-1.37-0.76-0.64-0.79
Net Debt / EBITDA-3.97-3.97—————————
Debt / FCF—-1.44—————————
Interest Coverage4.814.81-760.26—————-221.52——

Net cash position: cash ($70M) exceeds total debt ($3M)

SLNO Liquidity & Efficiency

Short-term solvency ratios and asset-utilisation metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Current Ratio5.805.8015.6814.892.142.805.834.2613.1410.382.23
Quick Ratio5.555.5515.6814.892.142.805.834.2613.1410.381.84
Cash Ratio4.984.9815.5514.752.002.665.714.1812.839.871.60
Asset Turnover—0.34———————-39.800.26
Inventory Turnover0.180.18————————2.29
Days Sales Outstanding—54.07————————33.55

SLNO Shareholder Yields

Earnings, FCF, buyback, and dividend yields — total returns to shareholders

Dividends

Full dividend history and growth charts are on the Dividend History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Dividend Yield———————————
Payout Ratio———————————

Total Shareholder Return Metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016
Earnings Yield0.7%0.8%—————————
FCF Yield1.7%1.9%—————————
Buyback Yield3.6%4.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%12.4%
Total Shareholder Yield3.6%4.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%0.0%12.4%
Shares Outstanding—$54M$40M$16M$8M$5M$4M$2M$1M$598519$206766

Key Metrics

Growth RegimeMixed
ProfitabilityStrained
Balance SheetAdequate
Cash FlowMixed
Top Statement Risk

Binary regulatory approval dependency

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2026Q1)

Valuation Distorted by Milestone Inflows

According to recent financial data, Soleno's TTM P/E of 135.92 appears significantly elevated, reflecting market expectations for future commercial success rather than current earnings, which are heavily skewed by non-recurring milestone payments that do not represent a sustainable or predictable long-term earnings trajectory for the firm.

The forward P/E of 13.91 suggests that the market is pricing in a substantial ramp-up in profitability, likely contingent upon the successful commercial launch of DCCR. Investors should exercise caution, as these multiples are highly sensitive to the timing of regulatory milestones and may not account for the potential dilution required to fund the transition to a commercial-stage entity.

Capital Returns Remain Highly Volatile

Based on reported figures, Soleno's ROIC has fluctuated from a low of -39.5% in 2024Q1 to a positive 6.4% in 2026Q1, illustrating that the company's ability to compound capital is currently tethered to lumpy, non-operational revenue events rather than consistent, efficient deployment of invested capital into core business activities.

The recent positive return on capital is likely an anomaly driven by the recognition of licensing or milestone income. Without a stable commercial product, these returns do not indicate a sustainable competitive advantage or operational efficiency, but rather the successful execution of a specific, project-based financial event.

Working Capital Cycles Lack Predictability

As reported in quarterly filings, Soleno's cash conversion cycle has exhibited extreme volatility, swinging from -388 days in 2025Q2 to 318 days in 2026Q1, which highlights the company's lack of a standard operational supply chain and its reliance on irregular, milestone-driven cash inflows to manage working capital requirements.

The wide swings in DIO and DPO metrics suggest that the company is not managing inventory or payables in a traditional sense, but is instead navigating the accounting complexities of clinical-stage biotech partnerships. Analysts should monitor these metrics for signs of stabilization only after the company achieves consistent, recurring commercial revenue.

Liquidity Dependent on Milestone Timing

Based on the most recent quarterly data, Soleno maintains a current ratio of 5.62, which appears robust on the surface, yet this liquidity position remains highly vulnerable to the timing of milestone payments and the ongoing, high-burn nature of the company's intensive Phase III clinical trial program.

While the current ratio suggests a comfortable buffer, the lack of recurring revenue means that the company's liquidity is essentially a 'ticking clock' that requires constant monitoring. Investors should focus on the cash burn rate relative to the remaining runway, as the current liquidity position may not be sufficient to sustain operations through a prolonged regulatory review process.

Misapplication of Traditional P/E Multiples

The P/E ratio is frequently misapplied to Soleno, as it obscures the reality that current earnings are driven by non-recurring milestone events rather than operational product sales, leading to a potentially misleading assessment of the company's true earning power and its long-term valuation relative to commercial-stage peers.

Analysts should instead prioritize metrics such as cash burn rate and probability-weighted net present value of the DCCR program. Relying on P/E multiples in a pre-commercial context risks overestimating the company's current profitability and underestimating the significant capital requirements and execution risks inherent in the transition to a commercial-stage pharmaceutical business.

Download Financial Ratios Data

Includes 30+ ratios · 14 years · Updated daily

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SLNO — Frequently Asked Questions

Quick answers to the most common questions about buying SLNO stock.

What is Soleno Therapeutics, Inc.'s P/E ratio?

Soleno Therapeutics, Inc.'s current P/E ratio is 135.9x. The historical average is 118.7x. This places it at the 100th percentile of its historical range.

What is Soleno Therapeutics, Inc.'s EV/EBITDA?

Soleno Therapeutics, Inc.'s current EV/EBITDA is 158.9x. This enterprise value multiple compares the company's total value (equity + debt - cash) to its EBITDA.

What is Soleno Therapeutics, Inc.'s ROE?

Soleno Therapeutics, Inc.'s return on equity (ROE) is 6.0%. The historical average is -147.3%.

Is SLNO stock overvalued?

Based on historical data, Soleno Therapeutics, Inc. is trading at a P/E of 135.9x. This is at the 100th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.

What are Soleno Therapeutics, Inc.'s profit margins?

Soleno Therapeutics, Inc. has 98.6% gross margin and 7.9% operating margin.

How much debt does Soleno Therapeutics, Inc. have?

Soleno Therapeutics, Inc.'s Debt/EBITDA ratio is 0.2x, indicating low leverage. A ratio below 2x is generally considered financially healthy.