Latest Ratios: P/E Ratio 135.9x · EV/EBITDA 158.9x · ROE 6.0%. (2012–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $2.8B | $2.5B | $1.8B | $664M | $83M | $164M | $604M | $502M | $179M | $81M | $63M |
| Enterprise Value | $2.7B | $2.4B | $1.8B | $495M | $69M | $143M | $555M | $481M | $156M | $64M | $60M |
| P/E Ratio → | 135.92 | 118.72 | — | — | — | — | — | — | — | — | — |
| P/S Ratio | 14.51 | 13.21 | — | — | — | — | — | — | — | — | 43.29 |
| P/B Ratio | 6.40 | 5.59 | 7.37 | 4.21 | 8.03 | 9.19 | 13.27 | 33.58 | 5.90 | 3.05 | 18.28 |
| P/FCF | 59.13 | 53.84 | — | — | — | — | — | — | — | — | — |
| P/OCF | 59.04 | 53.75 | — | — | — | — | — | — | — | — | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 12.86 | — | — | — | — | — | — | — | — | 41.41 |
| EV / EBITDA | 158.87 | 144.29 | — | — | — | — | — | — | — | — | — |
| EV / EBIT | 180.30 | 92.85 | — | — | — | — | — | — | — | — | — |
| EV / FCF | — | 52.39 | — | — | — | — | — | — | — | — | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 98.6% | 98.6% | — | — | — | — | — | — | — | 100.1% | -4.0% |
| Operating Margin | 7.9% | 7.9% | — | — | — | — | — | — | — | 0.8% | -938.1% |
| Net Profit Margin | 11.0% | 11.0% | — | — | — | — | — | — | — | 1.0% | -831.6% |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | 6.0% | 6.0% | -87.4% | -46.5% | -171.0% | -97.6% | -81.5% | -135.7% | -46.8% | -104.6% | -362.4% |
| ROA | 4.7% | 4.7% | -68.7% | -37.6% | -77.6% | -61.5% | -47.8% | -75.7% | -32.5% | -70.3% | -175.3% |
| ROIC | 3.8% | 3.8% | -142.0% | — | — | — | — | -1898.3% | -128.1% | -180.0% | -1439.3% |
| ROCE | 3.7% | 3.7% | -78.0% | -43.9% | -104.4% | -75.1% | -71.3% | -62.3% | -36.4% | -59.2% | -307.0% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.01 | 0.01 | 0.22 | 0.00 | 0.01 | 0.03 | 0.00 | 0.02 | — | — | — |
| Debt / EBITDA | 0.16 | 0.16 | — | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | -0.15 | -0.14 | -1.07 | -1.40 | -1.17 | -1.08 | -1.37 | -0.76 | -0.64 | -0.79 |
| Net Debt / EBITDA | -3.97 | -3.97 | — | — | — | — | — | — | — | — | — |
| Debt / FCF | — | -1.44 | — | — | — | — | — | — | — | — | — |
| Interest Coverage | 4.81 | 4.81 | -760.26 | — | — | — | — | — | -221.52 | — | — |
Net cash position: cash ($70M) exceeds total debt ($3M)
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 5.80 | 5.80 | 15.68 | 14.89 | 2.14 | 2.80 | 5.83 | 4.26 | 13.14 | 10.38 | 2.23 |
| Quick Ratio | 5.55 | 5.55 | 15.68 | 14.89 | 2.14 | 2.80 | 5.83 | 4.26 | 13.14 | 10.38 | 1.84 |
| Cash Ratio | 4.98 | 4.98 | 15.55 | 14.75 | 2.00 | 2.66 | 5.71 | 4.18 | 12.83 | 9.87 | 1.60 |
| Asset Turnover | — | 0.34 | — | — | — | — | — | — | — | -39.80 | 0.26 |
| Inventory Turnover | 0.18 | 0.18 | — | — | — | — | — | — | — | — | 2.29 |
| Days Sales Outstanding | — | 54.07 | — | — | — | — | — | — | — | — | 33.55 |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | 0.7% | 0.8% | — | — | — | — | — | — | — | — | — |
| FCF Yield | 1.7% | 1.9% | — | — | — | — | — | — | — | — | — |
| Buyback Yield | 3.6% | 4.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 12.4% |
| Total Shareholder Yield | 3.6% | 4.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 12.4% |
| Shares Outstanding | — | $54M | $40M | $16M | $8M | $5M | $4M | $2M | $1M | $598519 | $206766 |
Binary regulatory approval dependency
According to recent financial data, Soleno's TTM P/E of 135.92 appears significantly elevated, reflecting market expectations for future commercial success rather than current earnings, which are heavily skewed by non-recurring milestone payments that do not represent a sustainable or predictable long-term earnings trajectory for the firm.
The forward P/E of 13.91 suggests that the market is pricing in a substantial ramp-up in profitability, likely contingent upon the successful commercial launch of DCCR. Investors should exercise caution, as these multiples are highly sensitive to the timing of regulatory milestones and may not account for the potential dilution required to fund the transition to a commercial-stage entity.
Based on reported figures, Soleno's ROIC has fluctuated from a low of -39.5% in 2024Q1 to a positive 6.4% in 2026Q1, illustrating that the company's ability to compound capital is currently tethered to lumpy, non-operational revenue events rather than consistent, efficient deployment of invested capital into core business activities.
The recent positive return on capital is likely an anomaly driven by the recognition of licensing or milestone income. Without a stable commercial product, these returns do not indicate a sustainable competitive advantage or operational efficiency, but rather the successful execution of a specific, project-based financial event.
As reported in quarterly filings, Soleno's cash conversion cycle has exhibited extreme volatility, swinging from -388 days in 2025Q2 to 318 days in 2026Q1, which highlights the company's lack of a standard operational supply chain and its reliance on irregular, milestone-driven cash inflows to manage working capital requirements.
The wide swings in DIO and DPO metrics suggest that the company is not managing inventory or payables in a traditional sense, but is instead navigating the accounting complexities of clinical-stage biotech partnerships. Analysts should monitor these metrics for signs of stabilization only after the company achieves consistent, recurring commercial revenue.
Based on the most recent quarterly data, Soleno maintains a current ratio of 5.62, which appears robust on the surface, yet this liquidity position remains highly vulnerable to the timing of milestone payments and the ongoing, high-burn nature of the company's intensive Phase III clinical trial program.
While the current ratio suggests a comfortable buffer, the lack of recurring revenue means that the company's liquidity is essentially a 'ticking clock' that requires constant monitoring. Investors should focus on the cash burn rate relative to the remaining runway, as the current liquidity position may not be sufficient to sustain operations through a prolonged regulatory review process.
The P/E ratio is frequently misapplied to Soleno, as it obscures the reality that current earnings are driven by non-recurring milestone events rather than operational product sales, leading to a potentially misleading assessment of the company's true earning power and its long-term valuation relative to commercial-stage peers.
Analysts should instead prioritize metrics such as cash burn rate and probability-weighted net present value of the DCCR program. Relying on P/E multiples in a pre-commercial context risks overestimating the company's current profitability and underestimating the significant capital requirements and execution risks inherent in the transition to a commercial-stage pharmaceutical business.
Includes 30+ ratios · 14 years · Updated daily
DCF models, multiple analysis, and analyst estimates.
10-year return with dividends reinvested.
See how regular investing compounds over time.
Compare growth, multiples, and margins vs sector.
Quick answers to the most common questions about buying SLNO stock.
Soleno Therapeutics, Inc.'s current P/E ratio is 135.9x. The historical average is 118.7x. This places it at the 100th percentile of its historical range.
Soleno Therapeutics, Inc.'s current EV/EBITDA is 158.9x. This enterprise value multiple compares the company's total value (equity + debt - cash) to its EBITDA.
Soleno Therapeutics, Inc.'s return on equity (ROE) is 6.0%. The historical average is -147.3%.
Based on historical data, Soleno Therapeutics, Inc. is trading at a P/E of 135.9x. This is at the 100th percentile of its historical P/E range. Compare with industry peers and growth rates for a complete picture.
Soleno Therapeutics, Inc. has 98.6% gross margin and 7.9% operating margin.
Soleno Therapeutics, Inc.'s Debt/EBITDA ratio is 0.2x, indicating low leverage. A ratio below 2x is generally considered financially healthy.