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SDGRSchrödinger, Inc.
$16.49$1.2B
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  4. Financial Ratios

Schrödinger, Inc. (SDGR) Financial Ratios

Latest Ratios: P/E Ratio -11.7x · EV/EBITDA N/A · ROE -26.3%. (2017–2025 historical series)

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly

SDGR Valuation Multiples

Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017
Market Cap$1.2B$1.3B$1.4B$2.7B$1.3B$2.5B$4.8B———
Enterprise Value$1.1B$1.2B$1.4B$2.7B$1.4B$2.4B$4.6B———
P/E Ratio →-11.70——66.30——————
P/S Ratio4.825.136.7512.397.3517.8343.97———
P/B Ratio3.333.613.334.892.974.417.62———
P/FCF98.91105.42————334.25———
P/OCF88.6594.48————283.63———

P/E links to full P/E history page with 30-year chart

SDGR EV Ratios

Enterprise-value multiples — capital-structure-neutral measures of total business value

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017
EV / Revenue—4.666.6112.267.4917.5342.21———
EV / EBITDA——————————
EV / EBIT——————————
EV / FCF—95.68————320.85———

SDGR Profitability

Margins and return-on-capital ratios measuring operating efficiency

Margins

Full margin charts and quarterly trend are on the Earnings History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017
Gross Margin55.7%55.7%63.6%64.9%55.8%47.6%58.7%57.4%64.4%71.5%
Operating Margin-65.2%-65.2%-100.8%-81.9%-81.1%-80.8%-56.4%-45.3%-42.0%-34.2%
Net Profit Margin-40.4%-40.4%-90.2%18.8%-82.4%-72.8%-22.6%-28.7%-42.7%-31.2%

Return on Capital

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017
ROE-26.3%-26.3%-38.6%8.2%-29.7%-17.0%-9.2%———
ROA-13.3%-13.3%-23.0%5.5%-20.6%-13.4%-5.4%-17.8%-31.8%-30.0%
ROIC-39.4%-39.4%-34.4%-26.7%-22.2%-17.6%-27.8%———
ROCE-28.6%-28.6%-32.2%-28.4%-23.6%-16.7%-15.6%-38.0%-41.8%-47.3%

SDGR Leverage & Debt

Solvency and debt-coverage ratios — lower is generally safer

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017
Debt / Equity0.300.300.280.230.260.140.02———
Debt / EBITDA——————————
Net Debt / Equity—-0.33-0.07-0.050.06-0.07-0.31———
Net Debt / EBITDA——————————
Debt / FCF—-9.74————-13.40———
Interest Coverage————-48939.00—————

Net cash position: cash ($231M) exceeds total debt ($109M)

SDGR Liquidity & Efficiency

Short-term solvency ratios and asset-utilisation metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017
Current Ratio2.752.753.314.254.916.859.332.633.882.70
Quick Ratio2.752.753.314.254.916.859.332.633.882.70
Cash Ratio2.092.091.843.464.156.328.781.913.112.04
Asset Turnover—0.350.250.270.260.180.140.550.550.96
Inventory Turnover——————————
Days Sales Outstanding—118.46449.06150.13139.36107.31119.46109.8298.7163.96

SDGR Shareholder Yields

Earnings, FCF, buyback, and dividend yields — total returns to shareholders

Dividends

Full dividend history and growth charts are on the Dividend History page

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017
Dividend Yield——————————
Payout Ratio——————————

Total Shareholder Return Metrics

MetricTTMFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017
Earnings Yield———1.5%——————
FCF Yield1.0%0.9%————0.3%———
Buyback Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%———
Total Shareholder Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%———
Shares Outstanding—$73M$73M$75M$71M$71M$60M$63M$48M$6M

Key Metrics

Growth RegimeMixed
ProfitabilityNegative
Balance SheetHealthy
Cash FlowBurning
Top Statement Risk

Clinical Pipeline Execution Risk

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2026Q1)

Valuation Premium Reflects Platform Optionality

As reported in financial statements, Schrödinger trades at a price-to-sales multiple of 4.92, a valuation that appears to price in significant future milestone potential rather than current earnings, which remain negative as evidenced by the TTM P/E of -11.96 and the absence of positive forward earnings estimates.

The current P/S multiple suggests investors are valuing the company as a high-growth technology platform rather than a traditional biotech entity. This premium warrants caution, as the valuation relies heavily on the successful commercialization of internal assets rather than the predictable, albeit slower, cash flows from the core software licensing business.

Capital Efficiency Impaired by R&D

Based on reported figures, the company's ROIC has consistently remained in negative territory, reaching -18.2% in 2026Q1, which indicates that the substantial capital deployed into internal drug discovery programs is currently failing to generate a positive return on invested capital relative to the firm's cost of capital.

The persistent negative ROIC trend suggests that the company is in a heavy investment phase where the returns from its computational platform are being outpaced by the escalating costs of clinical development. Investors should monitor whether the company can achieve a positive inflection point as its internal pipeline matures and moves toward potential commercialization.

Working Capital Volatility Hinders Efficiency

According to recent SEC filings, the company's asset turnover ratio remains low at 0.09 in 2026Q1, reflecting a business model that is heavily reliant on intangible assets and long-term collaboration cycles rather than the rapid conversion of physical inventory into revenue-generating sales.

The significant fluctuations in DSO, which reached 228 days in 2025Q1, highlight the inherent difficulty in managing working capital when revenue is tied to lumpy, milestone-based payments. This inefficiency suggests that the company's cash conversion cycle is highly sensitive to the timing of partner payments, which may create liquidity gaps during periods of lower milestone activity.

Liquidity Buffer Supports Clinical Runway

As indicated by the provided data, the company maintains a current ratio of 2.74 as of 2026Q1, which suggests a healthy liquidity position that provides a necessary buffer to fund ongoing R&D and clinical operations despite the absence of consistent positive free cash flow from core operations.

While the current ratio has moderated from its peak of 4.64 in 2024Q1, the company's conservative debt-to-equity ratio of 0.34 indicates that management has successfully avoided over-leveraging the balance sheet. This financial discipline is critical, as it provides the company with the flexibility to continue its internal drug development efforts without immediate reliance on dilutive external financing.

Misapplication of SaaS Valuation Metrics

Investors frequently misapply standard SaaS valuation multiples like EV/Sales to Schrödinger, failing to account for the fact that a significant portion of the company's revenue is derived from high-variance, non-recurring milestone payments rather than the predictable, recurring subscription revenue typical of pure-play software companies.

Using SaaS multiples obscures the underlying risk profile of the drug discovery segment, which is inherently more volatile and capital-intensive than a traditional software business. A more appropriate approach would involve a sum-of-the-parts valuation that separates the stable software licensing business from the binary, high-risk clinical pipeline, thereby providing a clearer picture of the company's true earning power.

Download Financial Ratios Data

Includes 30+ ratios · 9 years · Updated daily

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SDGR — Frequently Asked Questions

Quick answers to the most common questions about buying SDGR stock.

What is Schrödinger, Inc.'s P/E ratio?

Schrödinger, Inc.'s current P/E ratio is -11.7x. The historical average is 66.3x.

What is Schrödinger, Inc.'s ROE?

Schrödinger, Inc.'s return on equity (ROE) is -26.3%. The historical average is -18.8%.

Is SDGR stock overvalued?

Based on historical data, Schrödinger, Inc. is trading at a P/E of -11.7x. Compare with industry peers and growth rates for a complete picture.

What are Schrödinger, Inc.'s profit margins?

Schrödinger, Inc. has 55.7% gross margin and -65.2% operating margin.