Latest Ratios: P/E Ratio -11.7x · EV/EBITDA N/A · ROE -26.3%. (2017–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $1.2B | $1.3B | $1.4B | $2.7B | $1.3B | $2.5B | $4.8B | — | — | — |
| Enterprise Value | $1.1B | $1.2B | $1.4B | $2.7B | $1.4B | $2.4B | $4.6B | — | — | — |
| P/E Ratio → | -11.70 | — | — | 66.30 | — | — | — | — | — | — |
| P/S Ratio | 4.82 | 5.13 | 6.75 | 12.39 | 7.35 | 17.83 | 43.97 | — | — | — |
| P/B Ratio | 3.33 | 3.61 | 3.33 | 4.89 | 2.97 | 4.41 | 7.62 | — | — | — |
| P/FCF | 98.91 | 105.42 | — | — | — | — | 334.25 | — | — | — |
| P/OCF | 88.65 | 94.48 | — | — | — | — | 283.63 | — | — | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 4.66 | 6.61 | 12.26 | 7.49 | 17.53 | 42.21 | — | — | — |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — |
| EV / FCF | — | 95.68 | — | — | — | — | 320.85 | — | — | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 55.7% | 55.7% | 63.6% | 64.9% | 55.8% | 47.6% | 58.7% | 57.4% | 64.4% | 71.5% |
| Operating Margin | -65.2% | -65.2% | -100.8% | -81.9% | -81.1% | -80.8% | -56.4% | -45.3% | -42.0% | -34.2% |
| Net Profit Margin | -40.4% | -40.4% | -90.2% | 18.8% | -82.4% | -72.8% | -22.6% | -28.7% | -42.7% | -31.2% |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -26.3% | -26.3% | -38.6% | 8.2% | -29.7% | -17.0% | -9.2% | — | — | — |
| ROA | -13.3% | -13.3% | -23.0% | 5.5% | -20.6% | -13.4% | -5.4% | -17.8% | -31.8% | -30.0% |
| ROIC | -39.4% | -39.4% | -34.4% | -26.7% | -22.2% | -17.6% | -27.8% | — | — | — |
| ROCE | -28.6% | -28.6% | -32.2% | -28.4% | -23.6% | -16.7% | -15.6% | -38.0% | -41.8% | -47.3% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.30 | 0.30 | 0.28 | 0.23 | 0.26 | 0.14 | 0.02 | — | — | — |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | -0.33 | -0.07 | -0.05 | 0.06 | -0.07 | -0.31 | — | — | — |
| Net Debt / EBITDA | — | — | — | — | — | — | — | — | — | — |
| Debt / FCF | — | -9.74 | — | — | — | — | -13.40 | — | — | — |
| Interest Coverage | — | — | — | — | -48939.00 | — | — | — | — | — |
Net cash position: cash ($231M) exceeds total debt ($109M)
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 2.75 | 2.75 | 3.31 | 4.25 | 4.91 | 6.85 | 9.33 | 2.63 | 3.88 | 2.70 |
| Quick Ratio | 2.75 | 2.75 | 3.31 | 4.25 | 4.91 | 6.85 | 9.33 | 2.63 | 3.88 | 2.70 |
| Cash Ratio | 2.09 | 2.09 | 1.84 | 3.46 | 4.15 | 6.32 | 8.78 | 1.91 | 3.11 | 2.04 |
| Asset Turnover | — | 0.35 | 0.25 | 0.27 | 0.26 | 0.18 | 0.14 | 0.55 | 0.55 | 0.96 |
| Inventory Turnover | — | — | — | — | — | — | — | — | — | — |
| Days Sales Outstanding | — | 118.46 | 449.06 | 150.13 | 139.36 | 107.31 | 119.46 | 109.82 | 98.71 | 63.96 |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | — | 1.5% | — | — | — | — | — | — |
| FCF Yield | 1.0% | 0.9% | — | — | — | — | 0.3% | — | — | — |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — | — | — |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | — | — | — |
| Shares Outstanding | — | $73M | $73M | $75M | $71M | $71M | $60M | $63M | $48M | $6M |
Clinical Pipeline Execution Risk
As reported in financial statements, Schrödinger trades at a price-to-sales multiple of 4.92, a valuation that appears to price in significant future milestone potential rather than current earnings, which remain negative as evidenced by the TTM P/E of -11.96 and the absence of positive forward earnings estimates.
The current P/S multiple suggests investors are valuing the company as a high-growth technology platform rather than a traditional biotech entity. This premium warrants caution, as the valuation relies heavily on the successful commercialization of internal assets rather than the predictable, albeit slower, cash flows from the core software licensing business.
Based on reported figures, the company's ROIC has consistently remained in negative territory, reaching -18.2% in 2026Q1, which indicates that the substantial capital deployed into internal drug discovery programs is currently failing to generate a positive return on invested capital relative to the firm's cost of capital.
The persistent negative ROIC trend suggests that the company is in a heavy investment phase where the returns from its computational platform are being outpaced by the escalating costs of clinical development. Investors should monitor whether the company can achieve a positive inflection point as its internal pipeline matures and moves toward potential commercialization.
According to recent SEC filings, the company's asset turnover ratio remains low at 0.09 in 2026Q1, reflecting a business model that is heavily reliant on intangible assets and long-term collaboration cycles rather than the rapid conversion of physical inventory into revenue-generating sales.
The significant fluctuations in DSO, which reached 228 days in 2025Q1, highlight the inherent difficulty in managing working capital when revenue is tied to lumpy, milestone-based payments. This inefficiency suggests that the company's cash conversion cycle is highly sensitive to the timing of partner payments, which may create liquidity gaps during periods of lower milestone activity.
As indicated by the provided data, the company maintains a current ratio of 2.74 as of 2026Q1, which suggests a healthy liquidity position that provides a necessary buffer to fund ongoing R&D and clinical operations despite the absence of consistent positive free cash flow from core operations.
While the current ratio has moderated from its peak of 4.64 in 2024Q1, the company's conservative debt-to-equity ratio of 0.34 indicates that management has successfully avoided over-leveraging the balance sheet. This financial discipline is critical, as it provides the company with the flexibility to continue its internal drug development efforts without immediate reliance on dilutive external financing.
Investors frequently misapply standard SaaS valuation multiples like EV/Sales to Schrödinger, failing to account for the fact that a significant portion of the company's revenue is derived from high-variance, non-recurring milestone payments rather than the predictable, recurring subscription revenue typical of pure-play software companies.
Using SaaS multiples obscures the underlying risk profile of the drug discovery segment, which is inherently more volatile and capital-intensive than a traditional software business. A more appropriate approach would involve a sum-of-the-parts valuation that separates the stable software licensing business from the binary, high-risk clinical pipeline, thereby providing a clearer picture of the company's true earning power.
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Quick answers to the most common questions about buying SDGR stock.
Schrödinger, Inc.'s current P/E ratio is -11.7x. The historical average is 66.3x.
Schrödinger, Inc.'s return on equity (ROE) is -26.3%. The historical average is -18.8%.
Based on historical data, Schrödinger, Inc. is trading at a P/E of -11.7x. Compare with industry peers and growth rates for a complete picture.
Schrödinger, Inc. has 55.7% gross margin and -65.2% operating margin.