Latest Ratios: P/E Ratio -68.7x · EV/EBITDA N/A · ROE -20.2%. (2014–2025 historical series)
Price-based multiples — how expensive the stock is relative to earnings, sales, book value, and cash flow
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $9.1B | $5.6B | $2.5B | $1.3B | $535M | $1.6B | $693M | $183M | $151M | $368M | $143M |
| Enterprise Value | $8.9B | $5.4B | $2.4B | $1.1B | $413M | $1.5B | $582M | $167M | $68M | $262M | $122M |
| P/E Ratio → | -68.71 | — | 9.13 | — | — | — | — | — | — | — | — |
| P/S Ratio | 196.85 | 120.66 | 5.78 | 21.69 | 20.13 | 57.91 | 24.22 | 790.27 | 4.87 | 18.34 | — |
| P/B Ratio | 14.57 | 9.03 | 3.72 | 3.87 | 2.48 | 5.28 | 2.48 | 2.28 | — | — | — |
| P/FCF | 161.52 | 99.01 | 13.74 | — | — | — | — | — | — | 114.80 | — |
| P/OCF | 157.07 | 96.28 | 13.64 | — | — | — | — | — | — | 95.05 | — |
P/E links to full P/E history page with 30-year chart
Enterprise-value multiples — capital-structure-neutral measures of total business value
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EV / Revenue | — | 118.10 | 5.58 | 18.60 | 15.54 | 53.60 | 20.33 | 721.03 | 2.21 | 13.06 | — |
| EV / EBITDA | — | — | 9.56 | — | — | — | — | — | — | — | — |
| EV / EBIT | — | — | 9.59 | — | — | — | — | — | — | — | — |
| EV / FCF | — | 96.90 | 13.27 | — | — | — | — | — | — | 81.73 | — |
Margins and return-on-capital ratios measuring operating efficiency
Full margin charts and quarterly trend are on the Earnings History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 97.3% | 97.3% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | — |
| Operating Margin | -343.6% | -343.6% | 58.2% | -156.1% | -494.2% | -460.0% | -225.4% | -34857.6% | -136.7% | -188.9% | — |
| Net Profit Margin | -282.8% | -282.8% | 63.3% | -131.6% | -479.3% | -458.9% | -231.1% | -33414.3% | -125.9% | -184.2% | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -20.2% | -20.2% | 54.4% | -28.6% | -49.4% | -43.3% | -36.8% | -96.5% | — | — | — |
| ROA | -18.4% | -18.4% | 49.9% | -26.1% | -42.8% | -37.4% | -27.6% | -52.4% | -25.7% | -28.7% | -68.3% |
| ROIC | -21.8% | -21.8% | 51.3% | -57.4% | -71.5% | -53.9% | -41.7% | -94.4% | — | — | — |
| ROCE | -23.9% | -23.9% | 48.9% | -33.8% | -50.5% | -42.8% | -32.0% | -69.2% | -36.1% | -36.3% | -65.8% |
Solvency and debt-coverage ratios — lower is generally safer
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.02 | 0.02 | 0.02 | 0.00 | 0.02 | 0.02 | 0.02 | 0.21 | — | — | — |
| Debt / EBITDA | — | — | 0.04 | — | — | — | — | — | — | — | — |
| Net Debt / Equity | — | -0.19 | -0.13 | -0.55 | -0.57 | -0.39 | -0.40 | -0.20 | — | — | — |
| Net Debt / EBITDA | — | — | -0.34 | — | — | — | — | — | — | — | — |
| Debt / FCF | — | -2.11 | -0.47 | — | — | — | — | — | — | -33.07 | — |
| Interest Coverage | — | — | — | — | — | — | -107.89 | -459.82 | — | — | — |
Net cash position: cash ($128M) exceeds total debt ($10M)
Short-term solvency ratios and asset-utilisation metrics
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 12.71 | 12.71 | 12.48 | 16.71 | 7.80 | 7.74 | 7.84 | 4.10 | 5.26 | 3.55 | 12.94 |
| Quick Ratio | 12.71 | 12.71 | 12.48 | 16.71 | 7.80 | 7.74 | 7.84 | 4.10 | 5.17 | 3.75 | 14.13 |
| Cash Ratio | 12.49 | 12.49 | 8.84 | 16.06 | 7.61 | 7.43 | 7.60 | 3.76 | 4.93 | 3.38 | 12.06 |
| Asset Turnover | — | 0.07 | 0.58 | 0.17 | 0.11 | 0.08 | 0.09 | 0.00 | 0.22 | 0.12 | — |
| Inventory Turnover | — | — | — | — | — | — | — | — | — | — | — |
| Days Sales Outstanding | — | 35.66 | 141.56 | 62.85 | 0.71 | 71.15 | 48.72 | 10673.48 | 54.14 | 33.04 | — |
Earnings, FCF, buyback, and dividend yields — total returns to shareholders
Full dividend history and growth charts are on the Dividend History page
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dividend Yield | — | — | — | — | — | — | — | — | — | — | — |
| Payout Ratio | — | — | — | — | — | — | — | — | — | — | — |
| Metric | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Earnings Yield | — | — | 11.0% | — | — | — | — | — | — | — | — |
| FCF Yield | 0.6% | 1.0% | 7.3% | — | — | — | — | — | — | 0.9% | — |
| Buyback Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Total Shareholder Yield | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Shares Outstanding | — | $64M | $65M | $57M | $49M | $46M | $34M | $26M | $22M | $18M | $7M |
Binary Clinical Trial Dependence
Based on reported figures, PTGX trades at a P/S ratio of 170.34, which suggests that investors are pricing the company as a platform-plus-late-stage-asset hybrid rather than a traditional revenue-generating entity, heavily discounting the current lack of commercial sales in favor of future milestone and royalty expectations.
The elevated P/S and P/B of 12.60 indicate that the market is assigning significant value to the Janssen-partnered JNJ-2113 and the rusfertide Phase 3 program. This valuation appears to imply a high probability of successful commercialization, as traditional fundamental metrics like P/E are rendered non-meaningful by the company's persistent pre-commercial operating losses.
As reported in financial statements, the company's ROIC has exhibited extreme volatility, swinging from 57.4% in 2024Q1 to -0.6% in 2026Q1, which highlights that returns on capital are currently driven by the timing of non-recurring collaboration payments rather than sustainable operational efficiency or asset utilization.
The erratic nature of these returns suggests that investors should monitor the underlying clinical progress rather than historical ROIC, which is structurally distorted by milestone accounting. The decay in returns over the last two years reflects the transition from high-margin milestone recognition to the heavy cash-burn phase of late-stage clinical development.
According to recent SEC filings, the company's DSO has fluctuated wildly from 8 days to over 3,000 days, indicating that working capital metrics are entirely dependent on the timing of milestone settlements from Janssen rather than the operational efficiency of a standard commercial sales cycle.
The lack of meaningful asset turnover, which remains near 0.01, confirms that the company is not yet generating value through traditional inventory or receivable management. This suggests that efficiency ratios are currently poor proxies for operational health and should be viewed as artifacts of the partnership-based business model.
Based on the reported current ratio of 17.76 as of 2026Q1, the company maintains a strong short-term liquidity position, though this buffer is rapidly being consumed by the high-burn clinical trial schedule required to advance the rusfertide program toward potential regulatory approval.
While the current ratio appears robust compared to sector peers, it warrants further investigation into the actual cash runway, as the company lacks recurring revenue to offset its substantial R&D expenditures. Investors should monitor the cash burn rate closely, as the current liquidity position may necessitate future dilutive financing if milestone payments are delayed.
The most commonly misapplied metric for PTGX is the Price-to-Sales ratio, which obscures the company's true financial health by treating sporadic, milestone-driven collaboration payments as sustainable revenue, thereby creating a false impression of growth trajectory that is not supported by underlying commercial product demand.
Analysts should instead focus on the cash burn rate and the progress of clinical endpoints, as these are the true drivers of value for a pre-commercial biotechnology firm. Relying on P/S or revenue growth rates may lead to significant misvaluation, as these figures are prone to extreme volatility based on the timing of contractual milestone recognition.
Includes 30+ ratios · 12 years · Updated daily
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Compare growth, multiples, and margins vs sector.
Quick answers to the most common questions about buying PTGX stock.
Protagonist Therapeutics, Inc.'s current P/E ratio is -68.7x. The historical average is 9.1x.
Protagonist Therapeutics, Inc.'s return on equity (ROE) is -20.2%. The historical average is -58.8%.
Based on historical data, Protagonist Therapeutics, Inc. is trading at a P/E of -68.7x. Compare with industry peers and growth rates for a complete picture.
Protagonist Therapeutics, Inc. has 97.3% gross margin and -343.6% operating margin.