Free cash flow remains consistently negative, with a peak quarterly outflow of $12.4 million in 2026Q1, highlighting a structural inability to generate self-sustaining operational cash.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Mar'14 | Mar'13 | Mar'12 | Mar'11 | Mar'10 | Mar'09 | Mar'08 | Mar'07 | Mar'06 |
|---|
| Cash from Operations | -35.47M | -28.12B | -27.18M | -10.84M | -17.03M | -9.44M | -4.35M | -6.09M | -6.35M | -4.53M | -1.89M | -1.13M | -1.63M | -1.97M | -2.34M | -2.31M | -3.96M | -3.27M | -5.4M | -2.94M | -1.32M |
| Operating CF Margin % | - | - | - | - | - | -116017.91% | -278255.85% | -506627.7% | -1819727.58% | -57598.6% | -94530.36% | -7892.85% | -1212.73% | -4049.75% | -2564.25% | -187.8% | -2246.1% | -1689.42% | -1164.6% | -1338.44% | -4228.64% |
| Operating CF Growth % | -370.09% | -103345.22% | -150.67% | 36.34% | -80.4% | -116.83% | 28.49% | 4.04% | -40.02% | -139.48% | -66.92% | 30.32% | 17.43% | 15.62% | -1.06% | 41.59% | -20.96% | 39.47% | -83.59% | -122.29% | - |
| Net Income | -40.62M | -39.72B | 2.78M | -13.21M | -18.06M | -9.4M | -5.66M | -7.4M | -7.46M | -4.79M | -2.57M | -1.53M | -2.04M | -2.19M | -2.55M | -3.43M | -4.76M | -4.08M | -6.99M | -3.67M | -1.69M |
| Depreciation & Amortization | 0 | 0 | 0 | 21.16K | 11.22K | 46.46K | 15.73K | 8.56K | 4.9K | 5.31K | 4.96K | 5.5K | 14.78K | 49.45K | 75.96K | 212.41K | 154.43K | 178.36K | 163.5K | 51.04K | 9.64K |
| Stock-Based Compensation | 857.19M | 857.63M | 825.81K | 271.54K | 487.63K | 0 | 414.51K | 647.39K | 789.21K | 552.11K | 425.25K | 401.56K | 520.5K | 70.78K | 194.77K | 528.89K | 960.73K | 859.58K | 0 | 0 | 0 |
| Deferred Taxes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | -19.64K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | 38.82B | 10.73B | -19.06M | -868.55K | -4.87M | 1.5M | 92.82K | -171.37K | 0 | -6.79K | 1.92K | 13.63K | 0 | 0 | 0 | 0 | 0 | 0 | 890.88K | 791.08K | 328.82K |
| Working Capital Changes | 4.51M | 14.75M | -11.73M | 2.94M | 5.4M | -1.59M | 784.63K | 822.01K | 324.33K | -295.68K | 245.76K | -6.47K | -124.01K | 101.55K | -56.85K | 374.14K | -307.3K | -232.1K | 526.98K | -115.59K | 24.65K |
| Change in Receivables | 0 | 0 | 0 | 0 | 0 | -17.57K | 34.63K | -19.55K | 0 | 0 | 0 | 0 | -230.17K | 0 | 49.38K | 31.82K | -71.94K | 115.12K | 0 | 0 | 0 |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | -135.27K | 1.11M | -6.11M | 4.96M | 2.68M | -32.09K | 0 | 0 | 331.44K | -303.52K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cash from Investing | -703 | -702K | -693 | -1.35K | -1.98K | 95.93K | -111.88K | -208 | -152 | -164 | -153 | -29.55K | 0 | 89.87K | 510.31K | 3.62M | -11.65K | 1.75M | 5.12M | -6.24M | -4.59M |
| Capital Expenditures | 0 | 0 | 0 | 0 | -1.98K | -6.13K | -108.67K | 0 | 0 | 0 | 0 | 0 | 0 | -1.25K | -4.64K | -21.73K | -11.37K | -89.71K | -493.29K | -181.51K | -82.63K |
| CapEx % of Revenue | - | - | - | - | - | 75.3% | 6943.51% | - | - | - | - | - | - | 2.57% | 5.1% | 1.77% | 6.46% | 46.33% | 106.31% | 82.54% | 263.88% |
| Acquisitions | 0 | 0 | 0 | 0 | 0 | 99.7K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | 701.3K | 0 | 0 | 0 | 0 | 0 | -3.21K | -208 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cash from Financing | 91.07M | 20.94B | 27.88M | 17.75M | 6.49M | 25.63M | 3.83M | 5.36M | 6.86M | 5.31M | 1.75M | 2.49M | 1.72M | 1.12M | 658.63K | 485.88K | 3.65M | 215.9K | 820.8K | 10.53M | 5.54M |
| Debt Issued (Net) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -89.32K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Equity Issued (Net) | 90.96M | 28.74M | 27.85M | 17.75M | 4.97M | 25.63M | 0 | 0 | 5.54M | 5.35M | 1.75M | 1.7M | 0 | 1.72M | 1.12M | 658.63K | 485.88K | 3.65M | 215.9K | 820.8K | 10.53M |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | 103.32K | 20.92B | 28.04K | 3.6K | 1.52M | 0 | 3.83M | 5.36M | 1.32M | 53.15K | 3.57K | 94.16K | 1.72M | 0 | 0 | -657.97K | 0 | 0 | 0 | 0 | 0 |
| Net Change in Cash | 55.45M | -7.17B | 693.02K | 6.72M | -11.07M | 16.17M | -632.75K | -727.94K | 513.87K | 777.5K | -142.23K | 632.85K | 90.98K | -765.94K | -1.17M | 1.79M | -319.42K | -1.31M | 536.46K | 1.34M | -374.89K |
| Free Cash Flow | -35.47M | -28.12B | -27.18M | -10.84M | -17.04M | -9.45M | -4.46M | -6.09M | -6.35M | -4.53M | -1.89M | -1.13M | -1.63M | -1.97M | -2.34M | -2.33M | -3.97M | -3.36M | -5.9M | -3.13M | -1.41M |
| FCF Margin % | - | - | - | - | - | -116093.17% | -285199.36% | -506627.7% | -1819727.58% | -57598.6% | -94530.36% | -7892.85% | -1212.73% | -4052.32% | -2569.35% | -189.56% | -2252.55% | -1735.75% | -1270.9% | -1420.97% | -4492.53% |
| FCF Growth % | -66.25% | -103345.22% | -150.67% | 36.35% | -80.3% | -111.69% | 26.71% | 4.04% | -40.02% | -139.48% | -66.92% | 30.32% | 17.49% | 15.74% | -0.32% | 41.21% | -18.07% | 43.01% | -88.71% | -122.14% | - |
| FCF per Share | -5.43 | -16.01 | -25.68 | -22.05 | -56.77 | -40.83 | -23.44 | -35.16 | -39.80 | -33.04 | -16.71 | -15.75 | -40.24 | -52.13 | -68.50 | -71.72 | -124.76 | -120.08 | -214.20 | -147.60 | -109.30 |
| FCF Conversion (FCF/Net Income) | 0.87x | 707.94x | -9.78x | 0.62x | 0.94x | 0.98x | 0.77x | 0.82x | 0.85x | 0.95x | 0.74x | 0.74x | 0.80x | 0.90x | 0.92x | 0.67x | 0.83x | 0.80x | 0.77x | 0.80x | 0.78x |
| Interest Paid | 0 | 0 | 0 | 201.39K | 87.07K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Imminent liquidity and dilution
As reported in financial statements, the relationship between net income and operating cash flow is highly erratic, with OCF/NI ratios fluctuating from 34.56 in 2024Q4 to -0.72 in 2024Q3, indicating that headline earnings are frequently distorted by non-cash accounting adjustments rather than operational performance.
The wide variance in the OCF/NI ratio suggests that investors should disregard net income as a proxy for operational health. The persistent disconnect between accounting losses and cash depletion highlights the reliance on non-operating items, likely related to warrant valuations, which masks the underlying cash burn.
Based on the company's reported figures, free cash flow has remained consistently negative over the last ten quarters, reaching a peak outflow of $12.4 million in 2026Q1, which underscores the structural inability of the current business model to generate self-sustaining cash flow from operations.
The trajectory of FCF outflows appears to be accelerating in recent periods, correlating with the advancement of clinical programs. This trend suggests that the company is entirely dependent on external capital markets to fund its research pipeline, as there is no evidence of a path toward FCF breakeven.
According to recent SEC filings, working capital changes have been highly inconsistent, ranging from a $6.1 million inflow in 2025Q2 to a $6.7 million outflow in 2024Q1, reflecting the unpredictable nature of cash management in a pre-revenue clinical-stage biotechnology environment.
These swings in working capital suggest that the company's cash position is sensitive to the timing of vendor payments and clinical trial milestones. Investors should monitor these fluctuations closely, as they can temporarily mask or exacerbate the underlying cash burn rate during critical development phases.
As indicated by the provided financial data, capital deployment is exclusively directed toward R&D and operational survival, with zero allocation to dividends or share repurchases, confirming that all available cash is prioritized for the advancement of the PMN310 program and general corporate overhead.
The absence of capital return programs is expected for a firm at this stage, yet the lack of non-dilutive partnership capital suggests that management has not yet achieved the necessary clinical validation to attract external funding. This forces a reliance on equity markets, which may continue to dilute existing shareholders.
Quick answers to the most common questions about buying PMN stock.
ProMIS Neurosciences, Inc. (PMN) generated $-28118.6M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
ProMIS Neurosciences, Inc. (PMN) reported negative free cash flow of $28.12B in 2025, indicating capital requirements exceeded cash from operations.
ProMIS Neurosciences, Inc. (PMN) spent $0.0M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.