Karyopharm Therapeutics Inc. (KPTI) Stock Price History
Historical prices from 2013 to 2026
- 1M
- +13.2%
- 3M
- +52.2%
- YTD
- +33.8%
- 1Y
- +127.4%
- 3Y
- -25.0%
- 5Y
- -42.4%
Loading 10-year price history...
KPTI Historical Performance
KPTI Annual Returns
Year-by-year price performance · 2013–2026
- 2013 annual price return
- +42.9%
- 2014 annual price return
- +62.6%
- 2015 annual price return
- -65.1%
- 2016 annual price return
- -30.2%
- 2017 annual price return
- -0.4%
- 2018 annual price return
- -5.5%
- 2019 annual price return
- +100.5%
- 2020 annual price return
- -17.3%
- 2021 annual price return
- -62.0%
- 2022 annual price return
- -52.0%
- 2023 annual price return
- -73.5%
- 2024 annual price return
- -25.0%
- 2025 annual price return
- -39.5%
- 2026 annual price return
- +30.9%
KPTI Stock Price Trajectory (2013–2026)
As of July 7, 2026, Karyopharm Therapeutics Inc. (KPTI) trades at $9.62, representing a +127.4% return over the past year. The stock has delivered a -93.7% total return over five years (-42.4% CAGR), reflecting challenging market conditions.
The stock reached its all-time high of $734.40 on December 8, 2014. From this peak, KPTI has corrected -98.7%, currently trading 29% above its 200-day moving average, indicating continued institutional support.
When compared to Healthcare sector peers PTCT (+78.1% 1Y), FOLD (+139.5% 1Y), and MGNX (+236.0% 1Y), KPTI has underperformed the peer group average. Compare KPTI vs PTCT →
KPTI Historical Price Data · from 2013
Rows 1–50 of 3,183| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-07-06 | 9.65 | 9.77 | 9.22 | 9.62 | 284K | +0.21% |
| 2026-07-02 | 9.70 | 9.96 | 9.45 | 9.60 | 315K | +0.52% |
| 2026-07-01 | 9.68 | 9.85 | 9.34 | 9.55 | 307K | -2.25% |
| 2026-06-30 | 10.11 | 10.48 | 9.72 | 9.77 | 599K | -3.12% |
| 2026-06-29 | 10.17 | 10.44 | 9.69 | 10.09 | 490K | -1.22% |
| 2026-06-26 | 9.45 | 10.25 | 9.43 | 10.21 | 0 | +7.93% |
| 2026-06-25 | 9.08 | 9.63 | 9.01 | 9.46 | 440K | +4.07% |
| 2026-06-24 | 9.73 | 10.09 | 9.02 | 9.09 | 348K | -5.80% |
| 2026-06-23 | 8.89 | 9.70 | 8.80 | 9.65 | 520K | +7.22% |
| 2026-06-22 | 9.16 | 9.23 | 8.85 | 9.00 | 302K | -0.22% |
| 2026-06-18 | 9.60 | 9.73 | 8.90 | 9.02 | 401K | -4.04% |
| 2026-06-17 | 9.20 | 9.83 | 9.06 | 9.40 | 283K | +3.30% |
| 2026-06-16 | 9.64 | 9.64 | 9.02 | 9.10 | 320K | -5.60% |
| 2026-06-15 | 9.65 | 9.79 | 9.37 | 9.64 | 48K | +1.47% |
| 2026-06-12 | 9.10 | 10.21 | 9.04 | 9.50 | 564K | +5.56% |
| 2026-06-11 | 9.11 | 9.22 | 8.96 | 9.00 | 196K | -1.21% |
| 2026-06-10 | 8.85 | 9.33 | 8.58 | 9.11 | 273K | +4.83% |
| 2026-06-09 | 8.68 | 9.00 | 8.44 | 8.69 | 324K | +2.24% |
| 2026-06-08 | 9.18 | 9.44 | 8.43 | 8.50 | 258K | -6.39% |
| 2026-06-05 | 9.04 | 9.21 | 8.84 | 9.08 | 258K | +0.11% |
| 2026-06-04 | 9.00 | 9.39 | 8.84 | 9.07 | 206K | +0.78% |
| 2026-06-03 | 9.00 | 9.09 | 8.49 | 9.00 | 500K | -2.49% |
| 2026-06-02 | 9.81 | 9.82 | 8.50 | 9.23 | 525K | -6.01% |
| 2026-06-01 | 9.15 | 9.88 | 8.99 | 9.82 | 329K | +7.91% |
| 2026-05-29 | 9.12 | 9.44 | 8.94 | 9.10 | 281K | -0.11% |
| 2026-05-28 | 8.98 | 9.25 | 8.72 | 9.11 | 173K | +1.45% |
| 2026-05-27 | 8.99 | 9.98 | 8.74 | 8.98 | 620K | +0.11% |
| 2026-05-26 | 8.24 | 9.05 | 8.22 | 8.97 | 480K | +9.93% |
| 2026-05-22 | 8.15 | 8.42 | 8.00 | 8.16 | 294K | +1.24% |
| 2026-05-21 | 7.82 | 8.24 | 7.75 | 8.06 | 517K | +1.00% |
| 2026-05-20 | 7.47 | 8.16 | 7.38 | 7.98 | 658K | +6.83% |
| 2026-05-19 | 7.14 | 7.50 | 6.85 | 7.47 | 410K | +4.62% |
| 2026-05-18 | 7.72 | 8.04 | 7.08 | 7.14 | 571K | -6.91% |
| 2026-05-15 | 8.71 | 9.09 | 7.50 | 7.67 | 996K | -13.82% |
| 2026-05-14 | 9.53 | 10.23 | 8.79 | 8.90 | 1.01M | +0.56% |
| 2026-05-13 | 8.99 | 9.03 | 8.57 | 8.85 | 948K | -0.73% |
| 2026-05-12 | 8.84 | 9.25 | 8.73 | 8.91 | 264K | +1.19% |
| 2026-05-11 | 8.69 | 9.27 | 8.45 | 8.81 | 463K | +1.97% |
| 2026-05-08 | 8.87 | 9.00 | 8.54 | 8.64 | 294K | -2.37% |
| 2026-05-07 | 9.15 | 9.15 | 8.68 | 8.85 | 165K | -1.88% |
| 2026-05-06 | 9.54 | 9.54 | 9.02 | 9.02 | 179K | -4.14% |
| 2026-05-05 | 9.31 | 9.53 | 9.21 | 9.41 | 190K | +1.18% |
| 2026-05-04 | 8.75 | 9.55 | 8.67 | 9.30 | 186K | +6.04% |
| 2026-05-01 | 8.35 | 8.81 | 8.25 | 8.77 | 229K | +5.54% |
| 2026-04-30 | 8.44 | 8.65 | 8.17 | 8.31 | 303K | -1.07% |
| 2026-04-29 | 8.59 | 8.59 | 8.11 | 8.40 | 265K | -2.33% |
| 2026-04-28 | 8.71 | 8.93 | 8.50 | 8.60 | 220K | -0.69% |
| 2026-04-27 | 8.99 | 9.22 | 8.60 | 8.66 | 459K | 0.00% |
| 2026-04-24 | 8.77 | 8.77 | 8.41 | 8.66 | 268K | -1.03% |
| 2026-04-23 | 9.61 | 9.61 | 8.72 | 8.75 | 514K | -8.38% |
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
10-year return with dividends reinvested.
DCA Calculator
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Peer Comparison
Compare growth, multiples, and margins vs sector.
KPTI — Frequently Asked Questions
Quick answers to the most common questions about buying KPTI stock.
How has KPTI stock performed recently?
KPTI returned +127.4% over the past year, beating its 5-year annualized CAGR of -42.4%. The stock trades above its 200-day moving average, confirming the uptrend.
What is KPTI's all-time high price?
Karyopharm Therapeutics Inc. reached $734.40 on 2014-12-08. The 52-week high is $10.99. Current 1-year return of +127.4% places the stock closer to historical peaks.
Where can I download KPTI historical price data?
This page provides KPTI daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2013-2026, downloadable in CSV format.