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ATXIAvenue Therapeutics, Inc.
$0.33$1M
Overview & Verdict
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ATXI logoAvenue Therapeutics, Inc.(ATXI)Earnings, Financials & Key Ratios

ATXI•NASDAQ
$0.33
Price updated Jul 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Specialty Pharma
AboutAvenue Therapeutics, Inc., a specialty pharmaceutical company, develops and commercializes products primarily for use in the acute/intensive care hospital setting. Its product candidate is intravenous Tramadol, a synthetic dual-acting opioid, which is in Phase III clinical trials for the treatment of post-operative acute pain. The company was incorporated in 2015 and is based in New York, New York.Show more
  • Revenue$1M
  • EBITDA-$3M+71.9%
  • Net Income-$3M+75.0%
  • EPS (Diluted)-0.93-3.3%
  • Gross Margin100%
  • EBITDA Margin-234.05%
  • Operating Margin-234.05%
  • Net Margin-207.19%
  • ROE-157.75%+83.0%

ATXI Price & Volume

Avenue Therapeutics, Inc. (ATXI) stock price & volume — 10-year historical chart

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Persistent Regulatory Hurdles Threaten Capital Solvency

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Contracting
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Binary Regulatory Approval Failure

Key Thesis Takeaways

  • Avenue Therapeutics remains a high-risk, pre-commercial entity whose valuation is entirely dependent on overcoming significant FDA regulatory barriers for its lead analgesic candidate.
  • The company lacks a sustainable, recurring revenue model, with historical top-line performance limited to a single $1.4M milestone payment in 2025Q2.
  • Investors face substantial dilution risk as the firm continues to burn through its remaining $2.4M cash balance to fund ongoing R&D and SG&A expenses.

Verdict Logic

the company's reliance on binary regulatory outcomes and a dwindling cash reserve of only $2.4M as of 2026Q1 present an unacceptable risk profile for institutional capital.

ATXI Growth Metrics

Avenue Therapeutics, Inc. (ATXI) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM87.17%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM88.04%

Return on Capital

10 Years-395.43%
5 Years-437.45%
3 Years-606.36%
Last Year-178.2%

ATXI Recent Earnings

Avenue Therapeutics, Inc. (ATXI) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 4/12 qtrs (50%)
Q2 2026Latest
May 8, 2026
Metric
Actual
Est
EPS
$0.21+99.6%
$56.25
Rev
—
—
Q2 2026
Mar 30, 2026
Metric
Actual
Est
EPS
$0.22+99.6%
$56.25
Rev
—
—
Q4 2025
Nov 13, 2025
Metric
Actual
Est
EPS
$0.21
—
Rev
—
—
Q3 2025
Aug 14, 2025
Metric
Actual
Est
EPS
$0.11
—
Rev
$1M
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 8, 2026
$0.21vs $56.25+99.6%
—
Q2 2026Mar 30, 2026
$0.22vs $56.25+99.6%
—
Q4 2025Nov 13, 2025
$0.21
—
Q3 2025Aug 14, 2025
$0.11
$1M
Based on last 12 quarters of dataView full earnings history →

Peers Comparison

Key metrics vs top competitors for Avenue Therapeutics, Inc. (ATXI)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ATXI logoATXIAvenue Therapeutics, Inc.Current
$0.33$1.09M-0.35—-207.19%-157.75%—
PCRX logoPCRXPacira BioSciences, Inc.
$25.59$1.01B159.943.63%1.27%1.31%—
COLL logoCOLLCollegium Pharmaceutical, Inc.
$37.47$1.22B21.6623.62%9.41%26.74%—
MNKD logoMNKDMannKind Corporation
$4.27$1.32B213.5022.23%-6.63%——
XTLB logoXTLBXTL Biopharmaceuticals Ltd.
$3.14$345.48K-0.33—-227.72%-25.53%—
NKTR logoNKTRNektar Therapeutics
$73.15$1.43B-7.52-43.89%-284.18%-87%—

Compare ATXI vs Peers

Avenue Therapeutics, Inc. (ATXI) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs PCRX

Most directly comparable listed peer for ATXI.

Scale Benchmark

vs MCK

Larger-name benchmark to compare ATXI against a more recognizable public peer.

Peer Set

Compare Top 5

vs PCRX, COLL, MNKD, XTLB

ATXI SEC Filings & Documents

Avenue Therapeutics, Inc. (ATXI) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Feb 23, 2026·SEC

Material company update

Dec 31, 2025·SEC

Material company update

Nov 18, 2025·SEC

10-K Annual Reports

3
FY 2026

Mar 30, 2026·SEC

FY 2025

Mar 31, 2025·SEC

FY 2024

Mar 18, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 8, 2026·SEC

FY 2025

Nov 13, 2025·SEC

FY 2025

Aug 14, 2025·SEC

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ATXI Frequently Asked Questions

Avenue Therapeutics, Inc. (ATXI) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Avenue Therapeutics, Inc.'s revenue?

Avenue Therapeutics, Inc. (ATXI) reported $1.4M in revenue for fiscal year 2025.

Is ATXI profitable?

Avenue Therapeutics, Inc. (ATXI) reported a net loss of $1.8M for fiscal year 2025.

Dividend & Returns
What is ATXI's return on equity?

Avenue Therapeutics, Inc. (ATXI) has a return on equity (ROE) of -157.8%. Negative ROE indicates the company is unprofitable.

What is Avenue Therapeutics, Inc.'s free cash flow?

Avenue Therapeutics, Inc. (ATXI) had negative free cash flow of $1.1M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ATXI back in 2015?

Total return calculator · dividends reinvested · 11+ years of data

See returns →