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SRPTSarepta Therapeutics, Inc.
$19.79$2.1B
Overview & Verdict
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SRPT logoSarepta Therapeutics, Inc.(SRPT)Earnings, Financials & Key Ratios

SRPT•NASDAQ
$19.79
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutSarepta Therapeutics, Inc., a commercial-stage biopharmaceutical company, focuses on the discovery and development of RNA-targeted therapeutics, gene therapies, and other genetic therapeutic modalities for the treatment of rare diseases. It offers EXONDYS 51 injection to treat duchenne muscular dystrophy (duchenne) in patients with confirmed mutation of the dystrophin gene that is amenable to exon 51 skipping; and VYONDYS 53 for the treatment of duchenne in patients with confirmed mutation of the dystrophin gene that is amenable to exon 53 skipping. The company is also developing AMONDYS 45, a product candidate that uses phosphorodiamidate morpholino oligomer chemistry and exon-skipping technology to skip exon 45 of the dystrophin gene; SRP-5051, a peptide conjugated PMO that binds exon 51 of dystrophin pre-mRNA; SRP-9001, a DMD micro-dystrophin gene therapy program; and SRP-9003, a limb-girdle muscular dystrophies gene therapy program. It has collaboration agreements with F. Hoffman-La Roche Ltd; Nationwide Children's Hospital; Lysogene; Duke University; Genethon; and StrideBio. The company was incorporated in 1980 and is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$2.2B+15.6%
  • EBITDA-$613M-339.7%
  • Net Income-$713M-403.3%
  • EPS (Diluted)-7.13-404.7%
  • Gross Margin59.9%-28.0%
  • EBITDA Margin-27.9%-307.4%
  • Operating Margin-29.92%-361.0%
  • Net Margin-32.45%-362.4%
  • ROE-53.47%-371.3%

SRPT Price & Volume

Sarepta Therapeutics, Inc. (SRPT) stock price & volume — 10-year historical chart

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Volatile Gene Therapy Revenue Masks Operational Risks

Investment Thesis • Updated 2026Q1

VerdictNeutral
Growth:Mixed
Profitability:Strained
Financial:Mixed
Cash Flow:Mixed
Primary Risk:Manufacturing and reimbursement volatility

Key Thesis Takeaways

  • Sarepta Therapeutics presents a complex investment profile characterized by high-growth potential in gene therapy offset by extreme revenue lumpiness and significant manufacturing cost pressures.
  • While the company has demonstrated the ability to achieve a 49.0% operating margin as of 2026Q1, the sustainability of these gains remains uncertain due to the inherent volatility of milestone-driven income and the risk of long-term revenue cannibalization.
  • Investors should monitor the company's ability to stabilize its cost-of-goods-sold, which saw gross margins collapse to 10.0% in 2025Q4, before assuming a consistent path toward long-term profitability.

Verdict Logic

while the forward P/E of 4.78 suggests potential value, the extreme volatility in free cash flow, which swung from a $629.3M outflow in 2025Q1 to a $229.4M inflow in 2025Q2, warrants a cautious wait-and-see approach.

SRPT Growth Metrics

Sarepta Therapeutics, Inc. (SRPT) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years111.06%
5 Years32.41%
3 Years33.06%
TTM-2.2%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM126.19%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM64.44%

Return on Capital

10 Years-28.17%
5 Years-13.01%
3 Years-8.99%
Last Year-23.98%

SRPT Recent Earnings

Sarepta Therapeutics, Inc. (SRPT) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 9/12 qtrs (75%)●Beat Revenue 10/12 qtrs (83%)
Q2 2026Latest
May 6, 2026
Metric
Actual
Est
EPS
$3.16+223.8%
$0.98
Rev
$731M+54.1%
$474M
Q1 2026
Feb 25, 2026
Metric
Actual
Est
EPS
$3.58-247.6%
$1.03
Rev
$443M+19.8%
$370M
Q4 2025
Nov 3, 2025
Metric
Actual
Est
EPS
$0.13-1400.0%
$0.01
Rev
$399M+2.0%
$391M
Q3 2025
Aug 6, 2025
Metric
Actual
Est
EPS
$2.02+142.8%
$0.83
Rev
$611M+15.2%
$531M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 6, 2026
$3.16vs $0.98+223.8%
$731Mvs $474M+54.1%
Q1 2026Feb 25, 2026
$3.58vs $1.03-247.6%
$443Mvs $370M+19.8%
Q4 2025Nov 3, 2025
$0.13vs $0.01-1400.0%
$399Mvs $391M+2.0%
Q3 2025Aug 6, 2025
$2.02vs $0.83+142.8%
$611Mvs $531M+15.2%
Based on last 12 quarters of dataView full earnings history →

Latest SRPT News

Recent stock market news and headlines for Sarepta Therapeutics, Inc. (SRPT)

Business Wire·Jun 30, 2026
Sarepta Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, granted equity awards on June 30, 2026 that were previously approved by the Compensation Committee of its Board of Directors under Sarepta's 2024 Employment Commencement Incentive Plan, as a material inducement to employment to 30 individuals hired by Sarepta in the second quarter of 2026. The equity awards were approved in accordance with Nasdaq Listing Rule.

Benzinga·Jun 30, 2026
Sarepta Moves Closer To FDA Approval For Duchenne Muscular Dystrophy Drugs

The U.S. Food and Drug Administration (FDA) accepted on Tuesday Sarepta Therapeutics Inc.'s (NASDAQ:SRPT) supplemental New Drug Applications seeking to convert the accelerated approvals of AMONDYS 45 (casimersen) and VYONDYS 53 (golodirsen) into traditional approvals for Duchenne muscular dystrophy (DMD).

GuruFocus·Jun 30, 2026
Sarepta Announces FDA Acceptance of sNDAs for AMONDYS 45® and VYONDYS 53®

Sarepta Therapeutics, Inc. (NASDAQ: SRPT), the leader in precision genetic medicine for rare diseases, today announced that the U.S. Food and Drug Administratio

Business Wire·Jun 30, 2026
Sarepta Announces FDA Acceptance of sNDAs for AMONDYS 45® and VYONDYS 53®

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, today announced that the U.S. Food and Drug Administration (FDA) has accepted for filing the supplemental New Drug Applications (sNDAs) for AMONDYS 45® (casimersen) and VYONDYS 53® (golodirsen) for the treatment of Duchenne muscular dystrophy (DMD). The FDA has assigned a Prescription Drug User Fee Act (PDUFA) target action data of February 28, 2027. The sNDA.

Zacks Investment Research·Jun 24, 2026
SRPT or PRTA: Which Is the Better Value Stock Right Now?

Investors interested in Medical - Biomedical and Genetics stocks are likely familiar with Sarepta Therapeutics (SRPT) and Prothena (PRTA). But which of these two stocks is more attractive to value investors?

Peers Comparison

Key metrics vs top competitors for Sarepta Therapeutics, Inc. (SRPT)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
SRPT logoSRPTSarepta Therapeutics, Inc.Current
$19.79$2.09B-2.7815.58%-32.45%-53.47%—
BMRN logoBMRNBioMarin Pharmaceutical Inc.
$60.35$11.61B33.5312.87%8.29%4.41%—
ALNY logoALNYAlnylam Pharmaceuticals, Inc.
$321.59$42.91B138.0265.19%13.46%98.29%—
RARE logoRAREUltragenyx Pharmaceutical Inc.
$35.87$3.53B-6.1520.13%-91.03%——
IONS logoIONSIonis Pharmaceuticals, Inc.
$86.33$14.27B-36.2733.87%-30.87%-58.57%—
FOLD logoFOLDAmicus Therapeutics, Inc.
$14.49$4.55B-164.8520.05%-4.27%-12.02%—

Compare SRPT vs Peers

Sarepta Therapeutics, Inc. (SRPT) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs BMRN

Most directly comparable listed peer for SRPT.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare SRPT against a more recognizable public peer.

Peer Set

Compare Top 5

vs BMRN, ALNY, RARE, IONS

SRPT SEC Filings & Documents

Sarepta Therapeutics, Inc. (SRPT) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 6, 2026·SEC

Material company update

Feb 25, 2026·SEC

Material company update

Feb 25, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 2, 2026·SEC

FY 2025

Feb 28, 2025·SEC

FY 2024

Feb 28, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 6, 2026·SEC

FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 6, 2025·SEC

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SRPT Frequently Asked Questions

Sarepta Therapeutics, Inc. (SRPT) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Sarepta Therapeutics, Inc.'s revenue?

Sarepta Therapeutics, Inc. (SRPT) reported $2.18B in revenue for fiscal year 2025. This represents a 2184084% increase from $0.1M in 1996.

How fast is Sarepta Therapeutics, Inc. growing?

Sarepta Therapeutics, Inc. (SRPT) grew revenue by 15.6% over the past year. This is strong growth.

Is SRPT profitable?

Yes, Sarepta Therapeutics, Inc. (SRPT) is profitable, generating $65.1M in net income for fiscal year 2025 (-32.5% net margin).

Dividend & Returns
What is SRPT's return on equity?

Sarepta Therapeutics, Inc. (SRPT) has a return on equity (ROE) of -53.5%. Negative ROE indicates the company is unprofitable.

What is Sarepta Therapeutics, Inc.'s free cash flow?

Sarepta Therapeutics, Inc. (SRPT) generated $107.1M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

What if you invested $1,000 in SRPT back in 1996?

Total return calculator · dividends reinvested · 30+ years of data

See returns →