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SLNSilence Therapeutics plc
$10.15$479M
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SLN logoSilence Therapeutics plc(SLN)Earnings, Financials & Key Ratios

SLN•NASDAQ
$10.15
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryRNA and Genome Editing Developers
AboutSilence Therapeutics plc, a biotechnology company, focuses on the discovery and development of novel ribonucleic acid (RNA) therapeutics in hematology, cardiovascular, and other rare and metabolic indications. The company's platform includes mRNAi GalNAc Oligonucleotide Discovery platform designed to accurately target specific disease-associated genes in the liver. It designs short interfering RNA molecules to harness the body's natural mechanism of RNA interference, and degrading messenger RNA molecules that encode specific targeted disease-associated proteins in a cell. The company is developing various product candidates, including SLN360, which is Phase I clinical trials for the treatment of cardiovascular disease with high lipoprotein; SLN124 that is in Phase I clinical trials for the treatment of non-transfusion dependent thalassemia, and Phase I clinical trials for the treatment of myelodysplastic syndrome; and SLN124 for the treatment of polycythemia vera. It has collaboration agreements with AstraZeneca PLC to discover, develop, and commercialize small interfering RNA therapeutics for the treatment of cardiovascular, renal, metabolic, and respiratory diseases; and Mallinckrodt Pharma IP Trading DAC to develop and commercialize RNAi drug targets designed to silence the complement cascade in complement-mediated disorders. The company also has a collaboration with Hansoh Pharmaceutical Group Company Limited to develop siRNAs for three undisclosed targets leveraging Silence's mRNAi GOLD platform. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc is headquartered in London, the United Kingdom.Show more
  • Revenue$559K-98.7%
  • EBITDA-$89M-42.2%
  • Net Income-$89M-95.6%
  • EPS (Diluted)-1.89+20.3%
  • Gross Margin61.54%-15.4%
  • EBITDA Margin-15956.71%-10904.3%
  • Operating Margin-16055.99%-10869.1%
  • Net Margin-15851.88%-15034.3%
  • ROE-90.27%-55.4%

SLN Price & Volume

Silence Therapeutics plc (SLN) stock price & volume — 10-year historical chart

Loading chart...

Clinical Pipeline Burn Outpaces Milestone Revenue

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Contracting
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Imminent liquidity and dilution

Key Thesis Takeaways

  • Silence Therapeutics faces a precarious financial outlook as its reliance on sporadic milestone payments fails to offset the high costs of its mRNAi GOLD platform development.
  • While the company maintains a proprietary clinical pipeline, the rapid erosion of its cash position from $121.3 million in 2024Q4 to $5.7 million in 2026Q1 suggests an urgent need for external capital.
  • Investors should monitor the sustainability of operations, as the current trajectory of accumulated deficits reaching $577.5 million indicates significant long-term dilution risk.

Verdict Logic

the company's cash position has plummeted to a critical $5.7 million as of 2026Q1, signaling an imminent liquidity crisis that necessitates immediate and potentially dilutive financing.

SLN Growth Metrics

Silence Therapeutics plc (SLN) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-36.65%
3 Years-68.36%
TTM-96.8%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-31.77%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-1.67%

Return on Capital

10 Years-51.52%
5 Years-56.54%
3 Years-52.73%
Last Year-59.12%

SLN Recent Earnings

Silence Therapeutics plc (SLN) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (64%)●Beat Revenue 4/12 qtrs (36%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$0.32+3.0%
$0.33
Rev
$422,000-66.4%
$1M
Q2 2026
Mar 5, 2026
Metric
Actual
Est
EPS
$0.25+21.9%
$0.32
Rev
$39,000-98.7%
$3M
Q4 2025
Nov 6, 2025
Metric
Actual
Est
EPS
$0.45-12.5%
$0.40
Rev
$159,000-94.9%
$3M
Q3 2025
Aug 7, 2025
Metric
Actual
Est
EPS
$0.54-100.0%
$0.27
Rev
$224,000-93.1%
$3M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$0.32vs $0.33+3.0%
$422,000vs $1M-66.4%
Q2 2026Mar 5, 2026
$0.25vs $0.32+21.9%
$39,000vs $3M-98.7%
Q4 2025Nov 6, 2025
$0.45vs $0.40-12.5%
$159,000vs $3M-94.9%
Q3 2025Aug 7, 2025
$0.54vs $0.27-100.0%
$224,000vs $3M-93.1%
Based on last 12 quarters of dataView full earnings history →

Latest SLN News

Recent stock market news and headlines for Silence Therapeutics plc (SLN)

Zacks Investment Research·Jun 25, 2026
Silence Therapeutics (SLN) Surges 26.0%: Is This an Indication of Further Gains?

Silence Therapeutics (SLN) saw its shares surge in the last session with trading volume being higher than average. The latest trend in earnings estimate revisions may not translate into further price increase in the near term.

Benzinga·Jun 24, 2026
This $300 Million Biotech May Be Deeply Mispriced: Analyst

Silence Therapeutics Plc (NASDAQ:SLN) stock rose Wednesday after Cantor Fitzgerald initiated coverage with an Overweight rating and a positive outlook for its lead drug candidate.

Peers Comparison

Key metrics vs top competitors for Silence Therapeutics plc (SLN)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
SLN logoSLNSilence Therapeutics plcCurrent
$10.15$479.42M-5.37-98.71%-15851.88%-90.27%—
ALNY logoALNYAlnylam Pharmaceuticals, Inc.
$321.59$42.91B138.0265.19%13.46%98.29%—
ARWR logoARWRArrowhead Pharmaceuticals, Inc.
$86.97$12.25B-7128.6923258.15%-48.38%-55.09%—
SRPT logoSRPTSarepta Therapeutics, Inc.
$19.79$2.09B-2.7815.58%2.98%4.89%—
NTLA logoNTLAIntellia Therapeutics, Inc.
$17.43$1.96B-4.5716.92%-597.04%-57.27%—
IONS logoIONSIonis Pharmaceuticals, Inc.
$86.33$14.27B-36.2733.87%-30.87%-58.57%—

Compare SLN vs Peers

Silence Therapeutics plc (SLN) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ALNY

Most directly comparable listed peer for SLN.

Scale Benchmark

vs MRK

Larger-name benchmark to compare SLN against a more recognizable public peer.

Peer Set

Compare Top 5

vs ALNY, ARWR, SRPT, NTLA

SLN SEC Filings & Documents

Silence Therapeutics plc (SLN) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 18, 2026·SEC

Material company update

May 7, 2026·SEC

Material company update

Mar 5, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 5, 2026·SEC

FY 2025

Feb 27, 2025·SEC

10-Q Quarterly Reports

4
FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 7, 2025·SEC

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SLN Frequently Asked Questions

Silence Therapeutics plc (SLN) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Silence Therapeutics plc's revenue?

Silence Therapeutics plc (SLN) reported $0.8M in revenue for fiscal year 2025.

How fast is Silence Therapeutics plc growing?

Silence Therapeutics plc (SLN) saw revenue decline by 98.7% over the past year.

Is SLN profitable?

Silence Therapeutics plc (SLN) reported a net loss of $75.0M for fiscal year 2025.

Dividend & Returns
What is SLN's return on equity?

Silence Therapeutics plc (SLN) has a return on equity (ROE) of -90.3%. Negative ROE indicates the company is unprofitable.

What is Silence Therapeutics plc's free cash flow?

Silence Therapeutics plc (SLN) had negative free cash flow of $65.7M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in SLN back in 1996?

Total return calculator · dividends reinvested · 30+ years of data

See returns →