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IOVAIovance Biotherapeutics, Inc.
$4.35$1.6B
Overview & Verdict
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IOVA logoIovance Biotherapeutics, Inc.(IOVA)Earnings, Financials & Key Ratios

IOVA•NASDAQ
$4.35
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutIovance Biotherapeutics, Inc., a clinical-stage biotechnology company, focuses on developing and commercializing cancer immunotherapy products to harness the power of a patient's immune system to eradicate cancer cells. It has six ongoing phase 2 clinical studies, including C-144-01, of its lead product candidate, lifileucel, for the treatment of metastatic melanoma; C-145-04, of its product candidate lifileucel for recurrent, metastatic, or persistent cervical cancer; and C-145-03, of its product candidate LN-145, for recurrent and/or metastatic head and neck squamous cell carcinoma. Iovance Biotherapeutics, Inc. has collaborations and licensing agreements with H. Lee Moffitt Cancer Center; M.D. Anderson Cancer Center; Ohio State University; Centre hospitalier de l'Université de Montreal; Cellectis S.A.; and Novartis Pharma AG. The company was formerly known as Lion Biotechnologies, Inc. and changed its name to Iovance Biotherapeutics, Inc. in June 2017. Iovance Biotherapeutics, Inc. was incorporated in 2007 and is headquartered in San Carlos, California.Show more
  • Revenue$264M+60.6%
  • EBITDA-$367M-4.5%
  • Net Income-$391M-5.1%
  • EPS (Diluted)-1.09+14.8%
  • Gross Margin97.23%+298.1%
  • EBITDA Margin-139.44%+34.9%
  • Operating Margin-153.08%+36.5%
  • Net Margin-148.38%+34.6%
  • ROE-55.5%+3.4%

IOVA Price & Volume

Iovance Biotherapeutics, Inc. (IOVA) stock price & volume — 10-year historical chart

Loading chart...

Persistent Cash Burn Challenges Commercial Scaling Efforts

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Expanding
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:High Cash Burn Rate

Key Thesis Takeaways

  • Iovance Biotherapeutics is navigating a high-stakes transition from clinical development to commercial-stage operations for its personalized TIL therapy platform.
  • While revenue growth has shown volatility, reaching $86.8M in 2025Q4, the company remains burdened by substantial operating losses exceeding $70M per quarter.
  • Investors should monitor the sustainability of the current capital structure, as the reliance on equity-based funding remains critical to offset the ongoing cash burn and support the complex, capital-intensive manufacturing infrastructure.

Verdict Logic

the company's precarious liquidity position, evidenced by only $196.5 million in cash against consistent quarterly operating losses, warrants extreme caution regarding potential future dilution.

IOVA Growth Metrics

Iovance Biotherapeutics, Inc. (IOVA) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM34.29%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM5.73%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM25.81%

Return on Capital

10 Years-53.81%
5 Years-58.43%
3 Years-59.99%
Last Year-51.62%

IOVA Recent Earnings

Iovance Biotherapeutics, Inc. (IOVA) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 6/12 qtrs (50%)●Beat Revenue 3/12 qtrs (25%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$0.19+0.0%
$0.19
Rev
$71M-8.2%
$78M
Q1 2026
Feb 24, 2026
Metric
Actual
Est
EPS
$0.18+18.2%
$0.22
Rev
$87M+7.4%
$81M
Q4 2025
Nov 6, 2025
Metric
Actual
Est
EPS
$0.25+13.8%
$0.29
Rev
$67M-17.9%
$82M
Q3 2025
Aug 7, 2025
Metric
Actual
Est
EPS
$0.33-13.8%
$0.29
Rev
$60M-23.5%
$78M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$0.19vs $0.19+0.0%
$71Mvs $78M-8.2%
Q1 2026Feb 24, 2026
$0.18vs $0.22+18.2%
$87Mvs $81M+7.4%
Q4 2025Nov 6, 2025
$0.25vs $0.29+13.8%
$67Mvs $82M-17.9%
Q3 2025Aug 7, 2025
$0.33vs $0.29-13.8%
$60Mvs $78M-23.5%
Based on last 12 quarters of dataView full earnings history →

Latest IOVA News

Recent stock market news and headlines for Iovance Biotherapeutics, Inc. (IOVA)

The Motley Fool·3 days ago
Heartflow vs. Iovance Biotherapeutics: Which Healthcare Stock Is a Better Buy in 2026?

Heartflow leverages AI-enabled software to dominate the non-invasive coronary diagnostic market, backed by a stable base of over 1,450 accounts. Iovance Biotherapeutics is pioneering personalized TIL therapies for cancer, backed by centralized manufacturing and significant revenue growth from its lead products.

The Motley Fool·Jun 23, 2026
Amgen vs. Iovance Biotherapeutics: Which Healthcare Stock Is a Better Buy in 2026?

Amgen provides a stable, diversified revenue base of nearly $36.7 billion with significant net income. Iovance Biotherapeutics offers high growth potential through its innovative cell therapies for advanced cancers.

GlobeNewsWire·Jun 19, 2026
Iovance Biotherapeutics Reports Inducement Grants under NASDAQ Listing Rule 5635(c)(4)

SAN CARLOS, Calif., June 19, 2026 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA) ("Iovance" or the “Company”), a biotechnology company focused on innovating, developing, and delivering novel polyclonal tumor infiltrating lymphocyte (“TIL”) therapies for patients with cancer, today announced that on June 18, 2026 (the “Date of Grant”), the Company approved the grant of inducement stock options covering an aggregate of 140,860 shares of Iovance's common stock to twenty-seven new, non-executive employees.

Seeking Alpha·Jun 17, 2026
Iovance Biotherapeutics: Commercial, Clinical And Regulatory Tailwinds

IOVA guides for $350M–$370M 2026 revenue (36% YoY growth), with Q2'26 expected to be a record Amtagvi quarter. Expansion into new indications (NSCLC, endometrial, sarcoma) and global markets underpins the pipeline-in-a-drug thesis. A more receptive FDA increases the likelihood of accelerated approvals based on single-arm data, streamlining IOVA's development path.

Peers Comparison

Key metrics vs top competitors for Iovance Biotherapeutics, Inc. (IOVA)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
IOVA logoIOVAIovance Biotherapeutics, Inc.Current
$4.35$1.56B-3.9960.6%-148.38%-55.5%—
ADCT logoADCTADC Therapeutics S.A.
$1.35$171.71M-1.2114.85%-173.02%——
FATE logoFATEFate Therapeutics, Inc.
$3.02$352.01M-2.63-51.24%-2056.79%-58.89%—
CRSP logoCRSPCRISPR Therapeutics AG
$60.77$5.86B-9.39-89.97%-13856.54%-30.88%—
NTLA logoNTLAIntellia Therapeutics, Inc.
$17.43$1.96B-4.5716.92%-597.04%-57.27%—
BEAM logoBEAMBeam Therapeutics Inc.
$37.92$3.9B-46.81120.01%-49.17%-5.89%—

Compare IOVA vs Peers

Iovance Biotherapeutics, Inc. (IOVA) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ADCT

Most directly comparable listed peer for IOVA.

Scale Benchmark

vs TMO

Larger-name benchmark to compare IOVA against a more recognizable public peer.

Peer Set

Compare Top 5

vs ADCT, FATE, CRSP, NTLA

IOVA SEC Filings & Documents

Iovance Biotherapeutics, Inc. (IOVA) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 7, 2026·SEC

Material company update

Mar 20, 2026·SEC

Material company update

Feb 24, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 24, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 28, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 7, 2025·SEC

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IOVA Frequently Asked Questions

Iovance Biotherapeutics, Inc. (IOVA) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Iovance Biotherapeutics, Inc.'s revenue?

Iovance Biotherapeutics, Inc. (IOVA) reported $285.6M in revenue for fiscal year 2025.

How fast is Iovance Biotherapeutics, Inc. growing?

Iovance Biotherapeutics, Inc. (IOVA) grew revenue by 60.6% over the past year. This is strong growth.

Is IOVA profitable?

Iovance Biotherapeutics, Inc. (IOVA) reported a net loss of $353.9M for fiscal year 2025.

Dividend & Returns
What is IOVA's return on equity?

Iovance Biotherapeutics, Inc. (IOVA) has a return on equity (ROE) of -55.5%. Negative ROE indicates the company is unprofitable.

What is Iovance Biotherapeutics, Inc.'s free cash flow?

Iovance Biotherapeutics, Inc. (IOVA) had negative free cash flow of $305.0M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in IOVA back in 2008?

Total return calculator · dividends reinvested · 18+ years of data

See returns →