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CLDICalidi Biotherapeutics, Inc.
$0.14$1M
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CLDI logoCalidi Biotherapeutics, Inc.(CLDI)Earnings, Financials & Key Ratios

CLDI•AMEX
$0.14
Price updated Jul 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutCalidi Biotherapeutics, Inc., a clinical stage immuno-oncology company, engages in developing immunotherapies for the treatment of cancer. It engages in advancing a potent allogeneic stem cell capable of carrying an anti-tumor payload for use in multiple oncology indications, including high-grade gliomas and solid tumors. The company's cell-based delivery platforms are designed to protect, amplify, and potentiate oncolytic viruses leading to enhanced efficacy and improved patient safety. Its pipeline of products candidates in the clinic includes NeuroNova that are allogeneic neural stem cells loaded with an oncolytic adenovirus for the treatment of high-grade gliomas; and SuperNova, which are allogeneic adipose-derived mesenchymal stem cells loaded with tumor-selective CAL1 oncolytic vaccinia virus for the treatment of advanced metastatic solid tumors. The company was founded in 2014 and is based in San Diego, California.Show more
  • Revenue$0
  • EBITDA-$19M+8.2%
  • Net Income-$20M+10.1%
  • EPS (Diluted)-5.95+83.3%
  • ROE-695.16%+38.2%

CLDI Price & Volume

Calidi Biotherapeutics, Inc. (CLDI) stock price & volume — 10-year historical chart

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Persistent Clinical Burn Challenges Capital Structure Sustainability

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Vulnerable
Cash Flow:Burning
Primary Risk:Imminent liquidity and dilution

Key Thesis Takeaways

  • Calidi Biotherapeutics remains a pre-revenue clinical-stage entity heavily reliant on dilutive financing to sustain its $2.4 million average quarterly R&D expenditure.
  • While the NeuroNova and SuperNova platforms represent the core value proposition, the company's inability to generate commercial revenue has resulted in a negative $145.7 million retained earnings balance.
  • Investors should monitor the precarious $6.6 million cash position, which appears insufficient to support long-term clinical development without further equity dilution.

Verdict Logic

the company's limited $6.6 million cash balance against consistent quarterly operating losses of approximately $4.2 million suggests an imminent liquidity risk that warrants extreme caution.

CLDI Growth Metrics

Calidi Biotherapeutics, Inc. (CLDI) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM4.4%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM82.72%

Return on Capital

10 Years-697.49%
5 Years-697.49%
3 Years-697.49%
Last Year-421.32%

Latest CLDI News

Recent stock market news and headlines for Calidi Biotherapeutics, Inc. (CLDI)

GlobeNewsWire·Jun 24, 2026
Calidi Biotherapeutics Presents New Data on CLD-501, Its In Situ T-Cell Engager Candidate Targeting TROP-2 at the T-Cell Engager Therapeutic Summit

SAN DIEGO, June 24, 2026 (GLOBE NEWSWIRE) -- Calidi Biotherapeutics, Inc. (NYSE American: CLDI) (“Calidi” or the “Company”), a biotechnology company pioneering the development of targeted genetic medicines, presented data today at the T-cell Engager Therapeutic Summit in San Diego, California. The Company presented data on its approach of simultaneously activating T-cells while inducing the expression of T-cell engagers specifically in situ in the tumor microenvironment (“TME”).

GlobeNewsWire·Jun 23, 2026
Calidi Biotherapeutics Appoints Former Genentech/Roche and Celgene Executive Corsee Sanders, Ph.D., to Board of Directors

SAN DIEGO, June 23, 2026 (GLOBE NEWSWIRE) -- Calidi Biotherapeutics, Inc. (NYSE American: CLDI) (“Calidi” or “the Company”), a biotechnology company pioneering the development of targeted genetic medicines, today announced the appointment of Corsee Sanders, Ph.D., to the Board of Directors, effective June 17, 2026.

GlobeNewsWire·Jun 16, 2026
Calidi Biotherapeutics Receives Positive Pre-IND Feedback from US FDA for CLD-401 Indicating Agreement on its Current Development Strategy as it Advances Towards a First-in-Human Study

IND enabling studies with CLD-401 to continue with IND submission targeted by end of 2026 as Calidi continues to explore regulatory filing for CLD-401 in Australia in parallel IND enabling studies with CLD-401 to continue with IND submission targeted by end of 2026 as Calidi continues to explore regulatory filing for CLD-401 in Australia in parallel

Peers Comparison

Key metrics vs top competitors for Calidi Biotherapeutics, Inc. (CLDI)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
CLDI logoCLDICalidi Biotherapeutics, Inc.Current
$0.14$1.06M-0.02——-695.16%—
IMVT logoIMVTImmunovant, Inc.
$40.09$8.23B-14.47——-68.16%—
TGTX logoTGTXTG Therapeutics, Inc.
$53.52$8.19B19.3287.32%65.95%87.36%—
ONCY logoONCYOncolytics Biotech Inc.
$0.86$96.1M-2.97————
CGEN logoCGENCompugen Ltd.
$2.39$225.98M6.29161.14%48.57%55.68%—
VVOS logoVVOSVivos Therapeutics, Inc.
$0.48$2.82M-0.2316.05%-128.36%-2337.65%—

Compare CLDI vs Peers

Calidi Biotherapeutics, Inc. (CLDI) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IMVT

Most directly comparable listed peer for CLDI.

Scale Benchmark

vs TMO

Larger-name benchmark to compare CLDI against a more recognizable public peer.

Peer Set

Compare Top 5

vs IMVT, TGTX, ONCY, CGEN

CLDI SEC Filings & Documents

Calidi Biotherapeutics, Inc. (CLDI) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Jun 18, 2026·SEC

Material company update

May 29, 2026·SEC

Material company update

May 14, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 27, 2026·SEC

FY 2025

Mar 31, 2025·SEC

10-Q Quarterly Reports

5
FY 2026

May 14, 2026·SEC

FY 2025

Nov 13, 2025·SEC

FY 2025

Aug 8, 2025·SEC

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CLDI Frequently Asked Questions

Calidi Biotherapeutics, Inc. (CLDI) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
Is CLDI profitable?

Calidi Biotherapeutics, Inc. (CLDI) reported a net loss of $19.0M for fiscal year 2025.

Dividend & Returns
What is CLDI's return on equity?

Calidi Biotherapeutics, Inc. (CLDI) has a return on equity (ROE) of -695.2%. Negative ROE indicates the company is unprofitable.

What is Calidi Biotherapeutics, Inc.'s free cash flow?

Calidi Biotherapeutics, Inc. (CLDI) had negative free cash flow of $18.4M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in CLDI back in 2020?

Total return calculator · dividends reinvested · 6+ years of data

See returns →