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AXSMAxsome Therapeutics, Inc.
$249.76$12.9B
Overview & Verdict
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AXSM logoAxsome Therapeutics, Inc.(AXSM)Earnings, Financials & Key Ratios

AXSM•NASDAQ
$242.60
Price updated Jul 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutAxsome Therapeutics, Inc., a biopharmaceutical company, engages in the development of novel therapies for central nervous system (CNS) disorders in the United States. The company's product pipeline includes AXS-05, a therapeutic for the treatment of major depressive disorder and resistant depression disorders; and that is in the Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation. It is also developing AXS-07, a novel, oral, rapidly absorbed, multi-mechanistic, and investigational medicine that has completed two Phase III trials for the acute treatment of migraine; AXS-12, a selective and potent norepinephrine reuptake inhibitor, which is in Phase III trial to treat narcolepsy; and AXS-14, a novel, oral, and investigational medicine that is in Phase III trial for the treatment of fibromyalgia. Axsome Therapeutics, Inc. has a research collaboration agreement with Duke University for evaluating AXS-05 in smoking cessation. The company was incorporated in 2012 and is based in New York, New York.Show more
  • Revenue$638M+65.5%
  • EBITDA-$160M+41.2%
  • Net Income-$183M+36.2%
  • EPS (Diluted)-3.68+38.6%
  • Gross Margin92.56%+1.3%
  • EBITDA Margin-25.09%+64.5%
  • Operating Margin-26.51%+63.6%
  • Net Margin-28.69%+61.5%
  • ROE-252.11%-8.8%

AXSM Price & Volume

Axsome Therapeutics, Inc. (AXSM) stock price & volume — 10-year historical chart

Loading chart...

Commercial Scaling Challenges Amidst Rising Leverage

Investment Thesis • Updated 2026Q1

VerdictNeutral
Growth:Expanding
Profitability:Negative
Financial:Strained
Cash Flow:Burning
Primary Risk:High financial leverage

Key Thesis Takeaways

  • Axsome Therapeutics demonstrates robust top-line momentum with 57.4% year-over-year revenue growth in 2026Q1, driven by the successful market penetration of its CNS portfolio.
  • However, the company faces significant financial headwinds, characterized by a deepening $1.4 billion accumulated deficit and a debt-to-equity ratio that has surged to 3.97.
  • Investors should monitor the firm's ability to achieve operating leverage, as the current reliance on external capital to fund $185.0 million in quarterly SG&A expenses remains a critical risk to long-term solvency.

Verdict Logic

while revenue growth is impressive, the company's current ratio has tightened to 1.39, suggesting that liquidity constraints may necessitate further dilutive financing to sustain operations.

AXSM Growth Metrics

Axsome Therapeutics, Inc. (AXSM) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years133.68%
TTM63.88%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM32.33%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM35.36%

Return on Capital

10 Years-94.92%
5 Years-84.16%
3 Years-63.7%
Last Year-52.12%

AXSM Recent Earnings

Axsome Therapeutics, Inc. (AXSM) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 8/12 qtrs (67%)●Beat Revenue 7/12 qtrs (58%)
Q2 2026Latest
May 4, 2026
Metric
Actual
Est
EPS
$1.26-48.2%
$0.85
Rev
$189M-0.8%
$191M
Q1 2026
Feb 23, 2026
Metric
Actual
Est
EPS
$0.71-1.4%
$0.70
Rev
$195M+0.7%
$193M
Q4 2025
Nov 3, 2025
Metric
Actual
Est
EPS
$0.94-14.6%
$0.82
Rev
$171M-10.6%
$191M
Q3 2025
Aug 4, 2025
Metric
Actual
Est
EPS
$0.92+8.0%
$1.00
Rev
$150M+7.2%
$140M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 4, 2026
$1.26vs $0.85-48.2%
$189Mvs $191M-0.8%
Q1 2026Feb 23, 2026
$0.71vs $0.70-1.4%
$195Mvs $193M+0.7%
Q4 2025Nov 3, 2025
$0.94vs $0.82-14.6%
$171Mvs $191M-10.6%
Q3 2025Aug 4, 2025
$0.92vs $1.00+8.0%
$150Mvs $140M+7.2%
Based on last 12 quarters of dataView full earnings history →

Latest AXSM News

Recent stock market news and headlines for Axsome Therapeutics, Inc. (AXSM)

The Motley Fool·5 days ago
Is Axsome Therapeutics Stock a Millionaire Maker? Here's What the Numbers Say.

Axsome specializes in central nervous system disorders, including depression, migraine, and fibromyalgia. Axsome's Auvelity recently won approval to treat agitation associated with Alzheimer's disease.

Forbes·6 days ago
Why Axsome Stock Has Doubled In Nine Months

In this week's edition of InnovationRx, we look at Axsome's growing pipeline, HistoSonics innovative cancer treatment, state litigation over Medicaid work requirements, and more. To get it in your inbox, subscribe here.

GlobeNewsWire·Jun 26, 2026
Axsome Therapeutics Initiates FOCUS-3 Phase 3 Trial of Solriamfetol in Adolescents with Attention Deficit Hyperactivity Disorder (ADHD)

NEW YORK, June 26, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) disorders, today announced that the first patient has been dosed in the FOCUS-3 Phase 3 trial evaluating solriamfetol as a treatment for adolescents with attention deficit hyperactivity disorder (ADHD).

GlobeNewsWire·Jun 18, 2026
Axsome Therapeutics Highlights the Importance of Brain Health During Alzheimer's & Brain Awareness Month

NEW YORK, June 18, 2026 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) disorders, today announced it is joining patients, caregivers, and advocacy organizations in raising awareness of brain health and the impact of Alzheimer's disease during Alzheimer's & Brain Awareness Month. “Nearly everyone knows brain health is important, but many people aren't sure what steps to take to protect it,” said Wendy Vizek, Senior Vice President, Community Engagement and Field Operations at the Alzheimer's Association.

Fool - Investing News·Jun 16, 2026
3 Under-the-Radar Stocks to Buy and Hold for a Decade

All three could become highly prominent biotech companies within 10 years.

Peers Comparison

Key metrics vs top competitors for Axsome Therapeutics, Inc. (AXSM)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
AXSM logoAXSMAxsome Therapeutics, Inc.Current
$242.60$12.48B-65.9265.55%-28.69%-252.11%—
INVA logoINVAInnoviva, Inc.
$21.82$1.61B6.6118.52%118.91%47.59%—
SUPN logoSUPNSupernus Pharmaceuticals, Inc.
$47.41$2.73B-69.728.63%-3.74%-2.73%—
ACAD logoACADACADIA Pharmaceuticals Inc.
$25.77$4.41B11.2511.87%34.3%35.65%—
INTR logoINTRInter & Co, Inc.
$5.69$2.51B10.1650.54%8.99%14.24%—
PRAX logoPRAXPraxis Precision Medicines, Inc.
$313.50$9.06B-23.26-100%—-43.02%—

Compare AXSM vs Peers

Axsome Therapeutics, Inc. (AXSM) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs INVA

Most directly comparable listed peer for AXSM.

Scale Benchmark

vs MCK

Larger-name benchmark to compare AXSM against a more recognizable public peer.

Peer Set

Compare Top 5

vs INVA, SUPN, ACAD, INTR

AXSM SEC Filings & Documents

Axsome Therapeutics, Inc. (AXSM) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 4, 2026·SEC

Material company update

Apr 30, 2026·SEC

Material company update

Apr 1, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 23, 2026·SEC

FY 2025

Feb 18, 2025·SEC

FY 2024

Feb 23, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 4, 2026·SEC

FY 2025

Nov 3, 2025·SEC

FY 2025

Aug 4, 2025·SEC

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AXSM Frequently Asked Questions

Axsome Therapeutics, Inc. (AXSM) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Axsome Therapeutics, Inc.'s revenue?

Axsome Therapeutics, Inc. (AXSM) reported $708.2M in revenue for fiscal year 2025.

How fast is Axsome Therapeutics, Inc. growing?

Axsome Therapeutics, Inc. (AXSM) grew revenue by 65.5% over the past year. This is strong growth.

Is AXSM profitable?

Axsome Therapeutics, Inc. (AXSM) reported a net loss of $188.3M for fiscal year 2025.

Dividend & Returns
What is AXSM's return on equity?

Axsome Therapeutics, Inc. (AXSM) has a return on equity (ROE) of -252.1%. Negative ROE indicates the company is unprofitable.

What is Axsome Therapeutics, Inc.'s free cash flow?

Axsome Therapeutics, Inc. (AXSM) had negative free cash flow of $71.0M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in AXSM back in 2013?

Total return calculator · dividends reinvested · 13+ years of data

See returns →