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SNDXSyndax Pharmaceuticals, Inc.
$22.08$1.9B
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SNDX logoSyndax Pharmaceuticals, Inc.(SNDX)Earnings, Financials & Key Ratios

SNDX•NASDAQ
$22.08
Price updated Jul 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutSyndax Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops therapies for the treatment of cancer. Its lead product candidates are SNDX-5613, which is in phase 1/2 clinical trial targeting the binding interaction of Menin with the mixed lineage leukemia 1 protein for the treatment of MLL-rearranged (MLLr) and nucleophosmin 1 mutant acute myeloid leukemia (NPM1c AML); and SNDX-6352 or axatilimab, a monoclonal antibody that blocks the colony stimulating factor 1, or CSF-1 receptor for the treatment of patients with chronic graft versus host disease (cGVHD). The company is also developing Entinostat. It also has collaborative research and development agreement with National Cancer Institute; a clinical trial agreement with Eastern Cooperative Oncology Group; and a license agreement with Kyowa Hakko Kirin Co., Ltd. Syndax Pharmaceuticals, Inc. was incorporated in 2005 and is headquartered in Waltham, Massachusetts.Massachusetts.Show more
  • Revenue$172M+627.8%
  • EBITDA-$273M+19.6%
  • Net Income-$285M+10.5%
  • EPS (Diluted)-3.29+11.8%
  • Gross Margin95.96%-0.6%
  • EBITDA Margin-158.44%+89.0%
  • Operating Margin-158.45%+89.0%
  • Net Margin-165.6%+87.7%
  • ROE-161.82%-113.8%

SNDX Price & Volume

Syndax Pharmaceuticals, Inc. (SNDX) stock price & volume — 10-year historical chart

Loading chart...

Clinical Scaling Pressures Erode Equity Capital Base

Investment Thesis • Updated 2026Q1

VerdictNegative
Growth:Mixed
Profitability:Negative
Financial:Strained
Cash Flow:Burning
Primary Risk:Binary Regulatory Approval Risk

Key Thesis Takeaways

  • Syndax Pharmaceuticals is currently navigating a high-stakes transition from a research-focused entity to a commercial-stage oncology firm, heavily reliant on the successful launch of its Menin-MLL inhibitor pipeline.
  • While the company has achieved significant revenue growth through milestone payments, the underlying operating margin of -52.7% as of 2026Q1 highlights the substantial financial burden of its clinical development programs.
  • Investors must weigh the potential of its late-stage assets against the risks of a rapidly depleting equity base, which has contracted to $41.6M, and the recent shift toward debt financing to sustain operations.

Verdict Logic

the company's reliance on debt financing to support a $346.5M debt load, combined with a persistent quarterly cash burn and an equity base that has shrunk to $41.6M, presents significant solvency risks for long-term investors.

SNDX Growth Metrics

Syndax Pharmaceuticals, Inc. (SNDX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years75.35%
5 Years157.68%
3 Years-
TTM396.72%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM26.56%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM40.31%

Return on Capital

10 Years-51.19%
5 Years-36.43%
3 Years-51.9%
Last Year-52.98%

SNDX Recent Earnings

Syndax Pharmaceuticals, Inc. (SNDX) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 9/12 qtrs (75%)●Beat Revenue 2/12 qtrs (29%)
Q2 2026Latest
Apr 30, 2026
Metric
Actual
Est
EPS
$0.48+18.6%
$0.59
Rev
$65M-7.0%
$70M
Q1 2026
Feb 26, 2026
Metric
Actual
Est
EPS
$0.78-33.6%
$0.58
Rev
$69M+6.9%
$64M
Q4 2025
Nov 3, 2025
Metric
Actual
Est
EPS
$0.70+5.4%
$0.74
Rev
$46M-27.6%
$63M
Q3 2025
Aug 4, 2025
Metric
Actual
Est
EPS
$0.83+17.0%
$1.00
Rev
$38M-16.9%
$46M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestApr 30, 2026
$0.48vs $0.59+18.6%
$65Mvs $70M-7.0%
Q1 2026Feb 26, 2026
$0.78vs $0.58-33.6%
$69Mvs $64M+6.9%
Q4 2025Nov 3, 2025
$0.70vs $0.74+5.4%
$46Mvs $63M-27.6%
Q3 2025Aug 4, 2025
$0.83vs $1.00+17.0%
$38Mvs $46M-16.9%
Based on last 12 quarters of dataView full earnings history →

Latest SNDX News

Recent stock market news and headlines for Syndax Pharmaceuticals, Inc. (SNDX)

GlobeNewsWire·5 days ago
Syndax Pharmaceuticals Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)

NEW YORK, July 01, 2026 (GLOBE NEWSWIRE) -- Syndax Pharmaceuticals (Nasdaq: SNDX), a commercial-stage biopharmaceutical company advancing innovative cancer therapies, today announced that on July 1, 2026, the Company granted inducement awards to purchase up to 250,700 shares of common stock to eight new employees under the Company's 2023 Inducement Plan. The stock options will vest over four years, with 25% of the underlying shares vesting on the one-year anniversary of the vesting commencement date and 1/48th of the underlying shares vesting monthly thereafter over 36 months, subject to the employee's continued service relationship with Syndax through the applicable vesting dates.

24/7 Wall Street·Jun 23, 2026
3 Biotech Takeover Targets Wall Street Is Watching After the Apogee Deal

Big pharma's appetite for clinical-stage biotech is back. The pending acquisition of Apogee Therapeutics by AbbVie (NYSE: ABBV | ABBV Price Prediction), targeting an atopic dermatitis and immunology developer, has reignited a question every healthcare portfolio manager is asking: who will be next?

Peers Comparison

Key metrics vs top competitors for Syndax Pharmaceuticals, Inc. (SNDX)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
SNDX logoSNDXSyndax Pharmaceuticals, Inc.Current
$22.08$1.95B-6.71627.84%-165.6%-161.82%—
KYMR logoKYMRKymera Therapeutics, Inc.
$114.76$9.37B-31.10-16.72%-612.17%-25.02%—
IMVT logoIMVTImmunovant, Inc.
$38.60$7.92B-13.94——-68.16%—
RVMD logoRVMDRevolution Medicines, Inc.
$189.99$40.39B-31.93——-83.22%—
TGTX logoTGTXTG Therapeutics, Inc.
$53.52$8.19B19.3287.32%65.95%87.36%—
PRAX logoPRAXPraxis Precision Medicines, Inc.
$313.50$9.06B-23.26-100%—-43.02%—

Compare SNDX vs Peers

Syndax Pharmaceuticals, Inc. (SNDX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs KYMR

Most directly comparable listed peer for SNDX.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare SNDX against a more recognizable public peer.

Peer Set

Compare Top 5

vs KYMR, IMVT, RVMD, TGTX

SNDX SEC Filings & Documents

Syndax Pharmaceuticals, Inc. (SNDX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 30, 2026·SEC

Material company update

Feb 26, 2026·SEC

Material company update

Jan 12, 2026·SEC

10-K Annual Reports

4
FY 2026

Feb 26, 2026·SEC

FY 2025

Mar 3, 2025·SEC

FY 2024

Feb 27, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Apr 30, 2026·SEC

FY 2025

Nov 3, 2025·SEC

FY 2025

Aug 4, 2025·SEC

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SNDX Frequently Asked Questions

Syndax Pharmaceuticals, Inc. (SNDX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Syndax Pharmaceuticals, Inc.'s revenue?

Syndax Pharmaceuticals, Inc. (SNDX) reported $217.2M in revenue for fiscal year 2025.

How fast is Syndax Pharmaceuticals, Inc. growing?

Syndax Pharmaceuticals, Inc. (SNDX) grew revenue by 627.8% over the past year. This is strong growth.

Is SNDX profitable?

Syndax Pharmaceuticals, Inc. (SNDX) reported a net loss of $243.2M for fiscal year 2025.

Dividend & Returns
What is SNDX's return on equity?

Syndax Pharmaceuticals, Inc. (SNDX) has a return on equity (ROE) of -161.8%. Negative ROE indicates the company is unprofitable.

What is Syndax Pharmaceuticals, Inc.'s free cash flow?

Syndax Pharmaceuticals, Inc. (SNDX) had negative free cash flow of $278.4M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in SNDX back in 2011?

Total return calculator · dividends reinvested · 15+ years of data

See returns →