Septerna, Inc.(SEPN)Earnings, Financials & Key RatiosSepterna, Inc. (SEPN) stock price & volume — 10-year historical chart
Investment Thesis • Updated 2026Q1
the company's reliance on milestone-driven revenue and the rapid depletion of cash reserves to $71.6 million in 2026Q1 present an unsustainable financial trajectory for long-term investors.
Septerna, Inc. (SEPN) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR
Septerna, Inc. (SEPN) EPS & revenue vs analyst estimates — last 4 quarters
| Quarter | Date | EPS (Act vs Est) | Revenue (Act vs Est) |
|---|---|---|---|
| Q2 2026Latest | May 12, 2026 | $0.19vs $0.51+62.7% | $27Mvs $17M+56.2% |
| Q2 2026 | Mar 9, 2026 | $0.24vs $0.23-4.3% | $24Mvs $18M+32.5% |
| Q4 2025 | Nov 10, 2025 | $0.09vs $0.19-147.4% | $21Mvs $17M+24.5% |
| Q3 2025 | Aug 11, 2025 | $0.56vs $0.05-1020.0% | $119,000vs $5M-97.6% |
Recent stock market news and headlines for Septerna, Inc. (SEPN)
Samira Shaikhly sold 11,798 shares of Common Stock on May 26, 2026, for a transaction value of ~$355,000. The transaction reduced direct Common Stock holdings by 93.7%, leaving 793 shares directly owned post-sale.
15,000 shares were exercised and sold for a total of ~$533,000 on June 22, 2026, at a weighted average price of around $35.51 per share. This transaction impacted 13.46% of Long's direct Common Stock holdings, reducing his position to 96,412 shares.
Key metrics vs top competitors for Septerna, Inc. (SEPN)
| Company | Price | Market Cap | P/E Ratio | Rev Growth (1Y) | Net Margin | ROE | Div Yield |
|---|---|---|---|---|---|---|---|
| $35.83 | $1.62B | -32.57 | 4174.51% | -106.37% | -12.19% | — | |
| $119.24 | $9.74B | -32.31 | -16.72% | -612.17% | -25.02% | — | |
| $3.84 | $1.72B | -2.67 | 26.92% | -844.46% | -54.32% | — | |
| $42.13 | $4.88B | -13.21 | — | — | -71.31% | — | |
| $56.63 | $3.26B | -23.60 | — | — | -15.14% | — | |
| $115.07 | $6.73B | -28.27 | -79.35% | -1027.25% | -55.42% | — |
Septerna, Inc. (SEPN) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.
Septerna, Inc. (SEPN) SEC filings — annual & quarterly reports (10-K, 10-Q)
May 11, 2026·SEC
Apr 13, 2026·SEC
Mar 9, 2026·SEC
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Septerna, Inc. (SEPN) stock FAQ — growth, dividends, profitability & financials explained
Septerna, Inc. (SEPN) reported $72.3M in revenue for fiscal year 2025.
Septerna, Inc. (SEPN) grew revenue by 4174.5% over the past year. This is strong growth.
Septerna, Inc. (SEPN) reported a net loss of $36.0M for fiscal year 2025.
Septerna, Inc. (SEPN) has a return on equity (ROE) of -12.2%. Negative ROE indicates the company is unprofitable.
Septerna, Inc. (SEPN) generated $106.9M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.
